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Q97A25 (GMHA_THEVO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable phosphoheptose isomerase
EC=5.3.1.28
Alternative name(s):
Sedoheptulose 7-phosphate isomerase
Gene names
Name:gmhA
Ordered Locus Names:TV0985
ORF Names:TVG1006486
OrganismThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) [Complete proteome] [HAMAP]
Taxonomic identifier273116 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length196 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate By similarity. HAMAP MF_00067

Catalytic activity

D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate. HAMAP MF_00067

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00067

Pathway

Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1. HAMAP MF_00067

Subcellular location

Cytoplasm By similarity HAMAP MF_00067.

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate By similarity. HAMAP MF_00067

Sequence similarities

Belongs to the SIS family. GmhA subfamily.

Contains 1 SIS domain.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentCytoplasm
   LigandMetal-binding
Zinc
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarbohydrate metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionD-sedoheptulose 7-phosphate isomerase activity

Inferred from electronic annotation. Source: InterPro

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

sugar binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 196196Probable phosphoheptose isomerase HAMAP MF_00067
PRO_0000136554

Regions

Domain43 – 196154SIS
Region58 – 603Substrate binding By similarity
Region100 – 1012Substrate binding By similarity
Region126 – 1283Substrate binding By similarity

Sites

Metal binding671Zinc By similarity
Metal binding711Zinc By similarity
Metal binding1781Zinc By similarity
Metal binding1861Zinc By similarity
Binding site711Substrate By similarity
Binding site1311Substrate By similarity
Binding site1781Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q97A25 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 80F09B2268673734

FASTA19621,178
        10         20         30         40         50         60 
MGRKDKYALI HYKLMDLSDY IEAGNKARRS IDLNHIEKIG RDIVNVFNSG GKLIVFGNGG 

        70         80         90        100        110        120 
SAADSQHFVA ELSGHFSKER KALPAMALTV NTSALTAISN DYSYDVVFSR QLEAFAKPGD 

       130        140        150        160        170        180 
YVVGISTSGN SVNVVKGLER AKELGCKTLA MTGRSGGKIA KVAEEAIMID SEVTSIIQEA 

       190 
HIAAIHMICS VIDSYY

« Hide

References

[1]"Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium."
Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y., Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T., Yamamoto Y., Aramaki H., Makino K., Suzuki M.
Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000) [PubMed: 11121031] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000011 Genomic DNA. Translation: BAB60127.1.
RefSeqNP_111475.1. NC_002689.2.

3D structure databases

ProteinModelPortalQ97A25.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1442062.
GenomeReviewsGene locus TV0985 in contig BA000011_GR.
NMPDRfig|273116.1.peg.956.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG671955.
OMAHITIIHI.
PhylomeDBQ97A25.
ProtClustDBPRK13937.

Family and domain databases

HAMAPMF_00067. GmhA.
[Tree]
InterProIPR020620. Phosphoheptose_isomerase.
IPR001347. SIS.
[Graphical view]
PfamPF01380. SIS. 1 hit.
[Graphical view]
PROSITEPS51464. SIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGMHA_THEVO
AccessionPrimary (citable) accession number: Q97A25
Entry history
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: October 1, 2001
Last modified: December 14, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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