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Q979U7

- NADK_THEVO

UniProt

Q979U7 - NADK_THEVO

Protein

NAD kinase

Gene

nadK

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei62 – 621Proton acceptorUniRule annotation
    Binding sitei67 – 671NADUniRule annotation
    Binding sitei140 – 1401NADUniRule annotation
    Binding sitei157 – 1571NADUniRule annotation
    Binding sitei159 – 1591NADUniRule annotation
    Binding sitei194 – 1941NAD; via carbonyl oxygenUniRule annotation
    Binding sitei229 – 2291NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi62 – 632NADUniRule annotation
    Nucleotide bindingi129 – 1302NADUniRule annotation
    Nucleotide bindingi170 – 1756NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTVOL273116:GC31-1063-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:TV1063
    ORF Names:TVG1088770
    OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
    Taxonomic identifieri273116 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
    ProteomesiUP000001017: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 272272NAD kinasePRO_0000120712Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273116.TVN1034.

    Structurei

    3D structure databases

    ProteinModelPortaliQ979U7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    KOiK00858.
    OMAiKLHWAGS.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q979U7-1 [UniParc]FASTAAdd to Basket

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    MKVAFVIRKD CKRCATIAKS IIELIPPDWE KIYDTEAAKF LGGVGKDITE    50
    ISADIIIAIG GDGTVLRILQ NAKGPVLGIN MGGLGFLTEI EIDEVGSSTY 100
    KLIRGEYKIN EAMKLKVYIN GRRLEDCTNE AVVHTDRIAR IRQFKIYVDG 150
    HFLTTIKSDG VIVATPTGSS SYSSSAGGPL LLPTVRGMVI SYLAPYSSRI 200
    KPVVVPSEST VEIKIAGNDQ DSLLILDGQK EYKIKSGDTV SISMSEEKAR 250
    FVSFRESIYD RLRDKVIKHV VN 272
    Length:272
    Mass (Da):29,876
    Last modified:October 1, 2001 - v1
    Checksum:i05AD7B7DA45E6381
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000011 Genomic DNA. Translation: BAB60205.1.
    RefSeqiNP_111553.1. NC_002689.2.

    Genome annotation databases

    EnsemblBacteriaiBAB60205; BAB60205; BAB60205.
    GeneIDi1441174.
    KEGGitvo:TVN1034.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000011 Genomic DNA. Translation: BAB60205.1 .
    RefSeqi NP_111553.1. NC_002689.2.

    3D structure databases

    ProteinModelPortali Q979U7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273116.TVN1034.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB60205 ; BAB60205 ; BAB60205 .
    GeneIDi 1441174.
    KEGGi tvo:TVN1034.

    Phylogenomic databases

    eggNOGi COG0061.
    KOi K00858.
    OMAi KLHWAGS.

    Enzyme and pathway databases

    BioCyci TVOL273116:GC31-1063-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

    Entry informationi

    Entry nameiNADK_THEVO
    AccessioniPrimary (citable) accession number: Q979U7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3