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Q979U7 (NADK_THEVO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:TV1063
ORF Names:TVG1088770
OrganismThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) [Complete proteome] [HAMAP]
Taxonomic identifier273116 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272NAD kinase HAMAP-Rule MF_00361
PRO_0000120712

Regions

Nucleotide binding62 – 632NAD By similarity
Nucleotide binding129 – 1302NAD By similarity
Nucleotide binding170 – 1756NAD By similarity

Sites

Active site621Proton acceptor By similarity
Binding site671NAD By similarity
Binding site1401NAD By similarity
Binding site1571NAD By similarity
Binding site1591NAD By similarity
Binding site1941NAD; via carbonyl oxygen By similarity
Binding site2291NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q979U7 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 05AD7B7DA45E6381

FASTA27229,876
        10         20         30         40         50         60 
MKVAFVIRKD CKRCATIAKS IIELIPPDWE KIYDTEAAKF LGGVGKDITE ISADIIIAIG 

        70         80         90        100        110        120 
GDGTVLRILQ NAKGPVLGIN MGGLGFLTEI EIDEVGSSTY KLIRGEYKIN EAMKLKVYIN 

       130        140        150        160        170        180 
GRRLEDCTNE AVVHTDRIAR IRQFKIYVDG HFLTTIKSDG VIVATPTGSS SYSSSAGGPL 

       190        200        210        220        230        240 
LLPTVRGMVI SYLAPYSSRI KPVVVPSEST VEIKIAGNDQ DSLLILDGQK EYKIKSGDTV 

       250        260        270 
SISMSEEKAR FVSFRESIYD RLRDKVIKHV VN 

« Hide

References

[1]"Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium."
Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y., Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T., Yamamoto Y., Aramaki H., Makino K., Suzuki M.
Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000011 Genomic DNA. Translation: BAB60205.1.
RefSeqNP_111553.1. NC_002689.2.

3D structure databases

ProteinModelPortalQ979U7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273116.TVN1034.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB60205; BAB60205; BAB60205.
GeneID1441174.
KEGGtvo:TVN1034.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
KOK00858.
OMAKLHWAGS.

Enzyme and pathway databases

BioCycTVOL273116:GC31-1063-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_THEVO
AccessionPrimary (citable) accession number: Q979U7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 1, 2001
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families