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Q979N9

- MDH_THEVO

UniProt

Q979N9 - MDH_THEVO

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Protein
Malate dehydrogenase
Gene
mdh, TV1121, TVG1151701
Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NAD By similarity
Binding sitei88 – 881Substrate By similarity
Binding sitei94 – 941Substrate By similarity
Binding sitei101 – 1011NAD By similarity
Binding sitei126 – 1261Substrate By similarity
Binding sitei157 – 1571Substrate By similarity
Active sitei181 – 1811Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NAD By similarity
Nucleotide bindingi124 – 1263NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciTVOL273116:GC31-1132-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:TV1121
ORF Names:TVG1151701
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001017: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Malate dehydrogenaseUniRule annotation
PRO_0000113497Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273116.TVN1097.

Structurei

3D structure databases

ProteinModelPortaliQ979N9.
SMRiQ979N9. Positions 5-312.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
KOiK00024.
OMAiYAPSAFV.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q979N9-1 [UniParc]FASTAAdd to Basket

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MARKKISVIG AGNVGATVAQ FLATKELGDV YLFDVVDGIP EGKALDIQEG    50
APHWGYDLDV VGFSTSDSSN YKNMEGSDVI VVTAGMARKP GMSREDLFDK 100
NVEIIADVSK NIKKYSPDSI IVVVSNPADI MAYALQKISG VDPQRIMGLG 150
GSLDSSRFRT FLAKELDVSV EDVNAFVIGG HGDDMVPFIR YSSVAGIPIE 200
KLLPKEKIDA IVKRTRFGGG EIVNYLKAGS AYYAPGISIT AMVESVIKDK 250
KRVIPCAAYI TGKHAEHYGI NNKFIGVPIK IGERGVEEIY DIDFLPEELE 300
LWKKSVASVE ASSKNVDEWL KKHPQ 325
Length:325
Mass (Da):35,390
Last modified:October 1, 2001 - v1
Checksum:i0B6012E92B6F9433
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB60263.1.
RefSeqiNP_111616.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB60263; BAB60263; BAB60263.
GeneIDi1441237.
KEGGitvo:TVN1097.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB60263.1 .
RefSeqi NP_111616.1. NC_002689.2.

3D structure databases

ProteinModelPortali Q979N9.
SMRi Q979N9. Positions 5-312.
ModBasei Search...

Protein-protein interaction databases

STRINGi 273116.TVN1097.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB60263 ; BAB60263 ; BAB60263 .
GeneIDi 1441237.
KEGGi tvo:TVN1097.

Phylogenomic databases

eggNOGi COG0039.
KOi K00024.
OMAi YAPSAFV.

Enzyme and pathway databases

BioCyci TVOL273116:GC31-1132-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Entry informationi

Entry nameiMDH_THEVO
AccessioniPrimary (citable) accession number: Q979N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2001
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi