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Protein

Peroxiredoxin

Gene

TV1123

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.UniRule annotation

Miscellaneous

The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.UniRule annotation

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44Cysteine sulfenic acid (-SOH) intermediateUniRule annotation1
Binding sitei119SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntioxidant, Oxidoreductase, Peroxidase

Names & Taxonomyi

Protein namesi
Recommended name:
PeroxiredoxinUniRule annotation (EC:1.11.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:TV1123
ORF Names:TVG1154375
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001017 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001351741 – 203PeroxiredoxinAdd BLAST203

Interactioni

Subunit structurei

Homodecamer. Pentamer of dimers that assemble into a ring structure.UniRule annotation

Protein-protein interaction databases

STRINGi273116.TVN1099.

Structurei

3D structure databases

ProteinModelPortaliQ979N7.
SMRiQ979N7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 156ThioredoxinUniRule annotationAdd BLAST154

Sequence similaritiesi

Belongs to the peroxiredoxin family. Prx6 subfamily.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiarCOG00312. Archaea.
COG0450. LUCA.
KOiK03386.
OMAiCTTEMAA.
OrthoDBiPOG093Z0BGG.

Family and domain databases

HAMAPiMF_00401. Peroxiredoxin. 1 hit.
InterProiView protein in InterPro
IPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR022915. Peroxiredoxin_TDXH.
IPR036249. Thioredoxin-like_sf.
IPR013766. Thioredoxin_domain.
PfamiView protein in Pfam
PF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
PIRSFiPIRSF000239. AHPC. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS51352. THIOREDOXIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q979N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVVLGQKAP DFTVNTSKGP ITLSNYRGKW VLLFSHPGDF TPVCTTEFIA
60 70 80 90 100
FTERYEDFQK LGVELIGLSI DSVFSHIAWI RDIKEHFGID IPFPIIADID
110 120 130 140 150
KEVAREYNLI DEKSGATVRG VFIIDPNQIV RWMIYYPAET GRNIEEIIRV
160 170 180 190 200
IKALQFNWDR KLATPANWQP GQEGIEPAPT TVDSSFKRDN EQGVKTWYLK

FVK
Length:203
Mass (Da):23,252
Last modified:October 1, 2001 - v1
Checksum:i9CE5C7536380BD9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA. Translation: BAB60265.1.
RefSeqiWP_010917357.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB60265; BAB60265; BAB60265.
GeneIDi1441239.
KEGGitvo:TVG1154375.

Similar proteinsi

Entry informationi

Entry nameiTDXH_THEVO
AccessioniPrimary (citable) accession number: Q979N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 1, 2001
Last modified: October 25, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families