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Protein

Peroxiredoxin

Gene

TV1123

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Protects cells against oxidative stress. Can reduce hydrogen peroxide and/or alkyl hydroperoxides using dithiothreitol as an electron donor (in vitro).UniRule annotation

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Cysteine sulfenic acid (-SOH) intermediateUniRule annotation
Binding sitei119 – 1191SubstrateUniRule annotation

GO - Molecular functioni

  1. peroxiredoxin activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell redox homeostasis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Enzyme and pathway databases

BioCyciTVOL273116:GC31-1134-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
PeroxiredoxinUniRule annotation (EC:1.11.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:TV1123
ORF Names:TVG1154375
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001017: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203PeroxiredoxinPRO_0000135174Add
BLAST

Interactioni

Subunit structurei

Homodecamer. Pentamer of dimers that assemble into a ring structure.UniRule annotation

Protein-protein interaction databases

STRINGi273116.TVN1099.

Structurei

3D structure databases

ProteinModelPortaliQ979N7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 156154ThioredoxinUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the AhpC/TSA family. TDXH subfamily.UniRule annotation
Contains 1 thioredoxin domain.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG0450.
KOiK03386.
OMAiWIVMFSH.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
HAMAPiMF_00401. Peroxiredoxin.
InterProiIPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR022915. Peroxiredoxin_TDXH_put.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
[Graphical view]
PIRSFiPIRSF000239. AHPC. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q979N7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVVLGQKAP DFTVNTSKGP ITLSNYRGKW VLLFSHPGDF TPVCTTEFIA
60 70 80 90 100
FTERYEDFQK LGVELIGLSI DSVFSHIAWI RDIKEHFGID IPFPIIADID
110 120 130 140 150
KEVAREYNLI DEKSGATVRG VFIIDPNQIV RWMIYYPAET GRNIEEIIRV
160 170 180 190 200
IKALQFNWDR KLATPANWQP GQEGIEPAPT TVDSSFKRDN EQGVKTWYLK

FVK
Length:203
Mass (Da):23,252
Last modified:October 1, 2001 - v1
Checksum:i9CE5C7536380BD9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA. Translation: BAB60265.1.
RefSeqiNP_111618.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB60265; BAB60265; BAB60265.
GeneIDi1441239.
KEGGitvo:TVN1099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA. Translation: BAB60265.1.
RefSeqiNP_111618.1. NC_002689.2.

3D structure databases

ProteinModelPortaliQ979N7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273116.TVN1099.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB60265; BAB60265; BAB60265.
GeneIDi1441239.
KEGGitvo:TVN1099.

Phylogenomic databases

eggNOGiCOG0450.
KOiK03386.
OMAiWIVMFSH.

Enzyme and pathway databases

BioCyciTVOL273116:GC31-1134-MONOMER.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
HAMAPiMF_00401. Peroxiredoxin.
InterProiIPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR022915. Peroxiredoxin_TDXH_put.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
[Graphical view]
PIRSFiPIRSF000239. AHPC. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Entry informationi

Entry nameiTDXH_THEVO
AccessioniPrimary (citable) accession number: Q979N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 1, 2001
Last modified: January 7, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.