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Q979N7

- TDXH_THEVO

UniProt

Q979N7 - TDXH_THEVO

Protein

Peroxiredoxin

Gene

TV1123

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Protects cells against oxidative stress. Can reduce hydrogen peroxide and/or alkyl hydroperoxides using dithiothreitol as an electron donor (in vitro).UniRule annotation

    Catalytic activityi

    2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei44 – 441Cysteine sulfenic acid (-SOH) intermediateUniRule annotation
    Binding sitei119 – 1191SubstrateUniRule annotation

    GO - Molecular functioni

    1. antioxidant activity Source: UniProtKB-KW
    2. peroxiredoxin activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell redox homeostasis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Antioxidant, Oxidoreductase

    Enzyme and pathway databases

    BioCyciTVOL273116:GC31-1134-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PeroxiredoxinUniRule annotation (EC:1.11.1.15UniRule annotation)
    Gene namesi
    Ordered Locus Names:TV1123
    ORF Names:TVG1154375
    OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
    Taxonomic identifieri273116 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
    ProteomesiUP000001017: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 203203PeroxiredoxinPRO_0000135174Add
    BLAST

    Interactioni

    Subunit structurei

    Homodecamer. Pentamer of dimers that assemble into a ring structure.UniRule annotation

    Protein-protein interaction databases

    STRINGi273116.TVN1099.

    Structurei

    3D structure databases

    ProteinModelPortaliQ979N7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 156154ThioredoxinUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the AhpC/TSA family. TDXH subfamily.UniRule annotation
    Contains 1 thioredoxin domain.UniRule annotation

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG0450.
    KOiK03386.
    OMAiRAITHYP.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    HAMAPiMF_00401. Peroxiredoxin.
    InterProiIPR000866. AhpC/TSA.
    IPR024706. Peroxiredoxin_AhpC-typ.
    IPR019479. Peroxiredoxin_C.
    IPR022915. Peroxiredoxin_TDXH_put.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF10417. 1-cysPrx_C. 1 hit.
    PF00578. AhpC-TSA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000239. AHPC. 1 hit.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q979N7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVVLGQKAP DFTVNTSKGP ITLSNYRGKW VLLFSHPGDF TPVCTTEFIA    50
    FTERYEDFQK LGVELIGLSI DSVFSHIAWI RDIKEHFGID IPFPIIADID 100
    KEVAREYNLI DEKSGATVRG VFIIDPNQIV RWMIYYPAET GRNIEEIIRV 150
    IKALQFNWDR KLATPANWQP GQEGIEPAPT TVDSSFKRDN EQGVKTWYLK 200
    FVK 203
    Length:203
    Mass (Da):23,252
    Last modified:October 1, 2001 - v1
    Checksum:i9CE5C7536380BD9A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000011 Genomic DNA. Translation: BAB60265.1.
    RefSeqiNP_111618.1. NC_002689.2.

    Genome annotation databases

    EnsemblBacteriaiBAB60265; BAB60265; BAB60265.
    GeneIDi1441239.
    KEGGitvo:TVN1099.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000011 Genomic DNA. Translation: BAB60265.1 .
    RefSeqi NP_111618.1. NC_002689.2.

    3D structure databases

    ProteinModelPortali Q979N7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273116.TVN1099.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB60265 ; BAB60265 ; BAB60265 .
    GeneIDi 1441239.
    KEGGi tvo:TVN1099.

    Phylogenomic databases

    eggNOGi COG0450.
    KOi K03386.
    OMAi RAITHYP.

    Enzyme and pathway databases

    BioCyci TVOL273116:GC31-1134-MONOMER.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    HAMAPi MF_00401. Peroxiredoxin.
    InterProi IPR000866. AhpC/TSA.
    IPR024706. Peroxiredoxin_AhpC-typ.
    IPR019479. Peroxiredoxin_C.
    IPR022915. Peroxiredoxin_TDXH_put.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF10417. 1-cysPrx_C. 1 hit.
    PF00578. AhpC-TSA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000239. AHPC. 1 hit.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

    Entry informationi

    Entry nameiTDXH_THEVO
    AccessioniPrimary (citable) accession number: Q979N7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3