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Q979N7

- TDXH_THEVO

UniProt

Q979N7 - TDXH_THEVO

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Protein
Peroxiredoxin
Gene
TV1123, TVG1154375
Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protects cells against oxidative stress. Can reduce hydrogen peroxide and/or alkyl hydroperoxides using dithiothreitol as an electron donor (in vitro) By similarity.UniRule annotation

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Cysteine sulfenic acid (-SOH) intermediate By similarity
Binding sitei119 – 1191Substrate By similarity

GO - Molecular functioni

  1. antioxidant activity Source: UniProtKB-KW
  2. peroxiredoxin activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell redox homeostasis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Enzyme and pathway databases

BioCyciTVOL273116:GC31-1134-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxiredoxin (EC:1.11.1.15)
Gene namesi
Ordered Locus Names:TV1123
ORF Names:TVG1154375
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001017: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203PeroxiredoxinUniRule annotation
PRO_0000135174Add
BLAST

Interactioni

Subunit structurei

Homodecamer. Pentamer of dimers that assemble into a ring structure By similarity.

Protein-protein interaction databases

STRINGi273116.TVN1099.

Structurei

3D structure databases

ProteinModelPortaliQ979N7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 156154Thioredoxin
Add
BLAST

Sequence similaritiesi

Contains 1 thioredoxin domain.

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG0450.
KOiK03386.
OMAiRAITHYP.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
HAMAPiMF_00401. Peroxiredoxin.
InterProiIPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR022915. Peroxiredoxin_TDXH_put.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
[Graphical view]
PIRSFiPIRSF000239. AHPC. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q979N7-1 [UniParc]FASTAAdd to Basket

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MPVVLGQKAP DFTVNTSKGP ITLSNYRGKW VLLFSHPGDF TPVCTTEFIA    50
FTERYEDFQK LGVELIGLSI DSVFSHIAWI RDIKEHFGID IPFPIIADID 100
KEVAREYNLI DEKSGATVRG VFIIDPNQIV RWMIYYPAET GRNIEEIIRV 150
IKALQFNWDR KLATPANWQP GQEGIEPAPT TVDSSFKRDN EQGVKTWYLK 200
FVK 203
Length:203
Mass (Da):23,252
Last modified:October 1, 2001 - v1
Checksum:i9CE5C7536380BD9A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB60265.1.
RefSeqiNP_111618.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB60265; BAB60265; BAB60265.
GeneIDi1441239.
KEGGitvo:TVN1099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB60265.1 .
RefSeqi NP_111618.1. NC_002689.2.

3D structure databases

ProteinModelPortali Q979N7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273116.TVN1099.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB60265 ; BAB60265 ; BAB60265 .
GeneIDi 1441239.
KEGGi tvo:TVN1099.

Phylogenomic databases

eggNOGi COG0450.
KOi K03386.
OMAi RAITHYP.

Enzyme and pathway databases

BioCyci TVOL273116:GC31-1134-MONOMER.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
HAMAPi MF_00401. Peroxiredoxin.
InterProi IPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR022915. Peroxiredoxin_TDXH_put.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
[Graphical view ]
PIRSFi PIRSF000239. AHPC. 1 hit.
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Entry informationi

Entry nameiTDXH_THEVO
AccessioniPrimary (citable) accession number: Q979N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 1, 2001
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi