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Protein

Peroxiredoxin

Gene

TV1123

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.UniRule annotation

Miscellaneous

The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.UniRule annotation

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44Cysteine sulfenic acid (-SOH) intermediateUniRule annotation1
Binding sitei119SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntioxidant, Oxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyciTVOL273116:G1G3C-1197-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
PeroxiredoxinUniRule annotation (EC:1.11.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:TV1123
ORF Names:TVG1154375
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001017 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001351741 – 203PeroxiredoxinAdd BLAST203

Interactioni

Subunit structurei

Homodecamer. Pentamer of dimers that assemble into a ring structure.UniRule annotation

Protein-protein interaction databases

STRINGi273116.TVN1099

Structurei

3D structure databases

ProteinModelPortaliQ979N7
SMRiQ979N7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 156ThioredoxinUniRule annotationAdd BLAST154

Sequence similaritiesi

Belongs to the peroxiredoxin family. Prx6 subfamily.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiarCOG00312 Archaea
COG0450 LUCA
KOiK03386
OMAiMSAGRNF
OrthoDBiPOG093Z0BGG

Family and domain databases

HAMAPiMF_00401 Peroxiredoxin, 1 hit
InterProiView protein in InterPro
IPR000866 AhpC/TSA
IPR024706 Peroxiredoxin_AhpC-typ
IPR019479 Peroxiredoxin_C
IPR022915 Peroxiredoxin_TDXH
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF10417 1-cysPrx_C, 1 hit
PF00578 AhpC-TSA, 1 hit
PIRSFiPIRSF000239 AHPC, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q979N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVVLGQKAP DFTVNTSKGP ITLSNYRGKW VLLFSHPGDF TPVCTTEFIA
60 70 80 90 100
FTERYEDFQK LGVELIGLSI DSVFSHIAWI RDIKEHFGID IPFPIIADID
110 120 130 140 150
KEVAREYNLI DEKSGATVRG VFIIDPNQIV RWMIYYPAET GRNIEEIIRV
160 170 180 190 200
IKALQFNWDR KLATPANWQP GQEGIEPAPT TVDSSFKRDN EQGVKTWYLK

FVK
Length:203
Mass (Da):23,252
Last modified:October 1, 2001 - v1
Checksum:i9CE5C7536380BD9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA Translation: BAB60265.1
RefSeqiWP_010917357.1, NC_002689.2

Genome annotation databases

EnsemblBacteriaiBAB60265; BAB60265; BAB60265
GeneIDi1441239
KEGGitvo:TVG1154375

Similar proteinsi

Entry informationi

Entry nameiTDXH_THEVO
AccessioniPrimary (citable) accession number: Q979N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 1, 2001
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health