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Q979C3 (MPTA_THEVO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTP cyclohydrolase MptA
EC=3.5.4.n2
Gene names
Name:mptA
Ordered Locus Names:TV1238
ORF Names:TVG1279013
OrganismThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) [Complete proteome] [HAMAP]
Taxonomic identifier273116 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma ›

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate. HAMAP-Rule MF_01527

Cofactor

Binds 1 Fe2+ ion per subunit By similarity. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis. HAMAP-Rule MF_01527

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   LigandIron
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionGTP cyclohydrolase activity

Inferred from electronic annotation. Source: HAMAP

iron ion binding

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 284284GTP cyclohydrolase MptA HAMAP-Rule MF_01527
PRO_0000147754

Sites

Site1421May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q979C3 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: ED1F698243BD96BC

FASTA28431,808
        10         20         30         40         50         60 
MIDFLDVQAS TPDIRISVDK VGIRRMKFPI KIGDEVAILS ADLYIDIPQT RKGADMSRAV 

        70         80         90        100        110        120 
ESIQSVLSRP SINLESLGIE ICKEALGRFN YASRVEVKIN GEYYKKSNGG YDEISLYIRT 

       130        140        150        160        170        180 
KCGIDGNIEN LTGLSYEAIT ACPCAMETTR ALISKDIPDS ENVLYYIPTV THNQRNRTKL 

       190        200        210        220        230        240 
IVSNNAGKIS FWDIYKVLES VQGKPLESLL KRIDEGKLVY EAHKKPKFVE DVVREVAFAA 

       250        260        270        280 
VTLLPLSDDD MVIVSSDSEE SIHPHNAYAS MKKRALDLKK ELNL

« Hide

References

[1]"Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium."
Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y., Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T., Yamamoto Y., Aramaki H., Makino K., Suzuki M.
Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000011 Genomic DNA. Translation: BAB60380.1.
RefSeqNP_111733.1. NC_002689.2.

3D structure databases

ProteinModelPortalQ979C3.
ModBaseSearch...

Protein-protein interaction databases

STRING273116.TVN1214.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB60380; BAB60380; BAB60380.
GeneID1441354.
KEGGtvo:TVN1214.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
KOK09007.
OMARSYETIH.
ProtClustDBPRK13675.

Enzyme and pathway databases

BioCycTVOL273116:GC31-1256-MONOMER.
UniPathwayUPA00065.

Family and domain databases

Gene3D3.10.270.10. 1 hit.
HAMAPMF_01527_A. GTP_cyclohydrol_A.
InterProIPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR022840. GTP_cyclohydrolase_MptA.
IPR002042. Uricase.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00294. TIGR00294. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMPTA_THEVO
AccessionPrimary (citable) accession number: Q979C3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2001
Last modified: May 29, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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