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Q979C2

- RIBL_THEVO

UniProt

Q979C2 - RIBL_THEVO

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Protein

FAD synthase

Gene

ribL

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.By similarity

Catalytic activityi

ATP + FMN = diphosphate + FAD.

Cofactori

Divalent metal cations.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201ATP; via amide nitrogen

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 102ATP
Nucleotide bindingi14 – 174ATP
Nucleotide bindingi91 – 944ATP

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. FMN adenylyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. FAD biosynthetic process Source: UniProtKB-HAMAP
  2. FMN metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

ATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

Enzyme and pathway databases

BioCyciTVOL273116:GC31-1257-MONOMER.
UniPathwayiUPA00277; UER00407.

Names & Taxonomyi

Protein namesi
Recommended name:
FAD synthase (EC:2.7.7.2)
Alternative name(s):
FMN adenylyltransferase
Flavin adenine dinucleotide synthase
Gene namesi
Name:ribL
Ordered Locus Names:TV1239
ORF Names:TVG1279046
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001017: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142FAD synthasePRO_0000406287Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi273116.TVN1215.

Structurei

Secondary structure

1
142
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86
Helixi15 – 2511
Beta strandi28 – 358
Helixi38 – 436
Helixi52 – 598
Beta strandi66 – 705
Helixi76 – 838
Beta strandi86 – 905
Helixi95 – 10814
Beta strandi113 – 1164

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3GLVX-ray1.99A/B1-142[»]
ProteinModelPortaliQ979C2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ979C2.

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal FAD synthase family.Curated

Phylogenomic databases

eggNOGiCOG0615.
KOiK14656.
OMAiIVLGHDQ.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_02115. FAD_synth_arch.
InterProiIPR004821. Cyt_trans-like.
IPR024902. FAD_synth_RibL.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

Q979C2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIRVMATGVF DILHLGHIHY LKESKKLGDE LVVVVARDST ARNNGKIPIF
60 70 80 90 100
DENSRLALIS ELKVVDRAIL GHEGDMMKTV IEVKPDIITL GYDQKFDEAE
110 120 130 140
LQSKINKLGI TVKIVRISKY DGQLNSSSSV RKKIMELIGE RY
Length:142
Mass (Da):16,009
Last modified:October 1, 2001 - v1
Checksum:iB9A106F982D0022E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB60381.1.
RefSeqiNP_111734.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB60381; BAB60381; BAB60381.
GeneIDi1441355.
KEGGitvo:TVN1215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB60381.1 .
RefSeqi NP_111734.1. NC_002689.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3GLV X-ray 1.99 A/B 1-142 [» ]
ProteinModelPortali Q979C2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273116.TVN1215.

Protocols and materials databases

DNASUi 1441355.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB60381 ; BAB60381 ; BAB60381 .
GeneIDi 1441355.
KEGGi tvo:TVN1215.

Phylogenomic databases

eggNOGi COG0615.
KOi K14656.
OMAi IVLGHDQ.

Enzyme and pathway databases

UniPathwayi UPA00277 ; UER00407 .
BioCyci TVOL273116:GC31-1257-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q979C2.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_02115. FAD_synth_arch.
InterProi IPR004821. Cyt_trans-like.
IPR024902. FAD_synth_RibL.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF01467. CTP_transf_2. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.
  2. "The crystal structure of the lipopolysaccharide core biosynthesis protein from Thermoplasma volcanium GSS1."
    Midwest center for structural genomics (MCSG)
    Submitted (MAY-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) IN COMPLEX WITH AMP.

Entry informationi

Entry nameiRIBL_THEVO
AccessioniPrimary (citable) accession number: Q979C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: October 1, 2001
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3