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Protein

DNA ligase

Gene

lig

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei248ATPUniRule annotation1
Active sitei250N6-AMP-lysine intermediateUniRule annotation1
Binding sitei255ATPUniRule annotation1
Binding sitei270ATPUniRule annotation1
Binding sitei300ATPUniRule annotation1
Binding sitei341ATPUniRule annotation1
Binding sitei418ATPUniRule annotation1
Binding sitei424ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTVOL273116:G1G3C-1346-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:TV1261
ORF Names:TVG1298537
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001017 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000596221 – 588DNA ligaseAdd BLAST588

Interactioni

Protein-protein interaction databases

STRINGi273116.TVN1237

Structurei

3D structure databases

ProteinModelPortaliQ979A1
SMRiQ979A1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
KOiK10747
OMAiWIKYKRD
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

Q979A1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFSLVTDAF EKMSKTTKRT ELTEILVELL KSADEDLQSL VYLIEGKLAP
60 70 80 90 100
DYQGIETQMS DKLIIKALSI VSNIPEEAVS ETYSKLGDIG SVAREIAAKK
110 120 130 140 150
NMRSLVNEDL TVKYVHDTLM RMAKTSGSGS TKARIDAYVD LALSGTPADL
160 170 180 190 200
MYITRIITGK LRIGVSDATI LDAIILAFSD EKYSEEIENA YNFHPDLGYI
210 220 230 240 250
AVQLRLGNLE SVINMGPTPM VPFKVMLAER LRSVDEIVQK MNGKCAFEYK
260 270 280 290 300
YDGMRTEIHI VDEKVRLFSR GNEETTGQFP DIVKSAKETF HVSSVILDGE
310 320 330 340 350
AVPYNPETGE LYPFQVISQR RGRKYDLDKV SNEIPITVFL FDIVYINGKD
360 370 380 390 400
LSKTPYAERR RILEGLFKEN DNFKLAKRIV SSDTGTITKF FNQAIEDGCE
410 420 430 440 450
GLVAKSMADD SYYKAGARGW LWIKLKRDYQ AQLWDTIDLT VVGAFMGHGR
460 470 480 490 500
RSGTYGALLL ATYNEKNDTF ETVCKLGSGF TDDVLFSLPK RFAEFVSKEK
510 520 530 540 550
PARVVSTIEP DVWIYPSIVM EIIGAEITIS PVHTCAFGII EKDAGLSIRF
560 570 580
PRFTGKWRDD KKPEDSTTTQ EIIEMYKEQK KTLTEEKS
Length:588
Mass (Da):66,218
Last modified:October 1, 2001 - v1
Checksum:i7FC5FC2549F3CD3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA Translation: BAB60403.1
RefSeqiWP_010917495.1, NC_002689.2

Genome annotation databases

EnsemblBacteriaiBAB60403; BAB60403; BAB60403
GeneIDi1441377
KEGGitvo:TVG1298537

Similar proteinsi

Entry informationi

Entry nameiDNLI_THEVO
AccessioniPrimary (citable) accession number: Q979A1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2001
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health