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Q979A1

- DNLI_THEVO

UniProt

Q979A1 - DNLI_THEVO

Protein

DNA ligase

Gene

lig

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei248 – 2481ATPUniRule annotation
    Active sitei250 – 2501N6-AMP-lysine intermediateUniRule annotation
    Binding sitei255 – 2551ATPUniRule annotation
    Binding sitei270 – 2701ATPUniRule annotation
    Binding sitei300 – 3001ATPUniRule annotation
    Binding sitei341 – 3411ATPUniRule annotation
    Binding sitei418 – 4181ATPUniRule annotation
    Binding sitei424 – 4241ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTVOL273116:GC31-1279-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:TV1261
    ORF Names:TVG1298537
    OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
    Taxonomic identifieri273116 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
    ProteomesiUP000001017: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 588588DNA ligasePRO_0000059622Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273116.TVN1237.

    Structurei

    3D structure databases

    ProteinModelPortaliQ979A1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    KOiK10747.
    OMAiLDPSGYN.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q979A1-1 [UniParc]FASTAAdd to Basket

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    MKFSLVTDAF EKMSKTTKRT ELTEILVELL KSADEDLQSL VYLIEGKLAP    50
    DYQGIETQMS DKLIIKALSI VSNIPEEAVS ETYSKLGDIG SVAREIAAKK 100
    NMRSLVNEDL TVKYVHDTLM RMAKTSGSGS TKARIDAYVD LALSGTPADL 150
    MYITRIITGK LRIGVSDATI LDAIILAFSD EKYSEEIENA YNFHPDLGYI 200
    AVQLRLGNLE SVINMGPTPM VPFKVMLAER LRSVDEIVQK MNGKCAFEYK 250
    YDGMRTEIHI VDEKVRLFSR GNEETTGQFP DIVKSAKETF HVSSVILDGE 300
    AVPYNPETGE LYPFQVISQR RGRKYDLDKV SNEIPITVFL FDIVYINGKD 350
    LSKTPYAERR RILEGLFKEN DNFKLAKRIV SSDTGTITKF FNQAIEDGCE 400
    GLVAKSMADD SYYKAGARGW LWIKLKRDYQ AQLWDTIDLT VVGAFMGHGR 450
    RSGTYGALLL ATYNEKNDTF ETVCKLGSGF TDDVLFSLPK RFAEFVSKEK 500
    PARVVSTIEP DVWIYPSIVM EIIGAEITIS PVHTCAFGII EKDAGLSIRF 550
    PRFTGKWRDD KKPEDSTTTQ EIIEMYKEQK KTLTEEKS 588
    Length:588
    Mass (Da):66,218
    Last modified:October 1, 2001 - v1
    Checksum:i7FC5FC2549F3CD3D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000011 Genomic DNA. Translation: BAB60403.1.
    RefSeqiNP_111756.1. NC_002689.2.
    WP_010917495.1. NC_002689.2.

    Genome annotation databases

    EnsemblBacteriaiBAB60403; BAB60403; BAB60403.
    GeneIDi1441377.
    KEGGitvo:TVN1237.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000011 Genomic DNA. Translation: BAB60403.1 .
    RefSeqi NP_111756.1. NC_002689.2.
    WP_010917495.1. NC_002689.2.

    3D structure databases

    ProteinModelPortali Q979A1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273116.TVN1237.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB60403 ; BAB60403 ; BAB60403 .
    GeneIDi 1441377.
    KEGGi tvo:TVN1237.

    Phylogenomic databases

    eggNOGi COG1793.
    KOi K10747.
    OMAi LDPSGYN.

    Enzyme and pathway databases

    BioCyci TVOL273116:GC31-1279-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

    Entry informationi

    Entry nameiDNLI_THEVO
    AccessioniPrimary (citable) accession number: Q979A1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3