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Q979A1 (DNLI_THEVO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:TV1261
ORF Names:TVG1298537
OrganismThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) [Complete proteome] [HAMAP]
Taxonomic identifier273116 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma

Protein attributes

Sequence length588 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 588588DNA ligase HAMAP-Rule MF_00407
PRO_0000059622

Sites

Active site2501N6-AMP-lysine intermediate By similarity
Binding site2481ATP By similarity
Binding site2551ATP By similarity
Binding site2701ATP By similarity
Binding site3001ATP By similarity
Binding site3411ATP By similarity
Binding site4181ATP By similarity
Binding site4241ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q979A1 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 7FC5FC2549F3CD3D

FASTA58866,218
        10         20         30         40         50         60 
MKFSLVTDAF EKMSKTTKRT ELTEILVELL KSADEDLQSL VYLIEGKLAP DYQGIETQMS 

        70         80         90        100        110        120 
DKLIIKALSI VSNIPEEAVS ETYSKLGDIG SVAREIAAKK NMRSLVNEDL TVKYVHDTLM 

       130        140        150        160        170        180 
RMAKTSGSGS TKARIDAYVD LALSGTPADL MYITRIITGK LRIGVSDATI LDAIILAFSD 

       190        200        210        220        230        240 
EKYSEEIENA YNFHPDLGYI AVQLRLGNLE SVINMGPTPM VPFKVMLAER LRSVDEIVQK 

       250        260        270        280        290        300 
MNGKCAFEYK YDGMRTEIHI VDEKVRLFSR GNEETTGQFP DIVKSAKETF HVSSVILDGE 

       310        320        330        340        350        360 
AVPYNPETGE LYPFQVISQR RGRKYDLDKV SNEIPITVFL FDIVYINGKD LSKTPYAERR 

       370        380        390        400        410        420 
RILEGLFKEN DNFKLAKRIV SSDTGTITKF FNQAIEDGCE GLVAKSMADD SYYKAGARGW 

       430        440        450        460        470        480 
LWIKLKRDYQ AQLWDTIDLT VVGAFMGHGR RSGTYGALLL ATYNEKNDTF ETVCKLGSGF 

       490        500        510        520        530        540 
TDDVLFSLPK RFAEFVSKEK PARVVSTIEP DVWIYPSIVM EIIGAEITIS PVHTCAFGII 

       550        560        570        580 
EKDAGLSIRF PRFTGKWRDD KKPEDSTTTQ EIIEMYKEQK KTLTEEKS 

« Hide

References

[1]"Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium."
Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y., Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T., Yamamoto Y., Aramaki H., Makino K., Suzuki M.
Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000011 Genomic DNA. Translation: BAB60403.1.
RefSeqNP_111756.1. NC_002689.2.

3D structure databases

ProteinModelPortalQ979A1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273116.TVN1237.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB60403; BAB60403; BAB60403.
GeneID1441377.
KEGGtvo:TVN1237.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
KOK10747.
OMAYIARFVV.
ProtClustDBPRK01109.

Enzyme and pathway databases

BioCycTVOL273116:GC31-1279-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_THEVO
AccessionPrimary (citable) accession number: Q979A1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2001
Last modified: February 19, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families