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Q979A1

- DNLI_THEVO

UniProt

Q979A1 - DNLI_THEVO

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Protein
DNA ligase
Gene
lig, TV1261, TVG1298537
Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei248 – 2481ATP By similarity
Active sitei250 – 2501N6-AMP-lysine intermediate By similarity
Binding sitei255 – 2551ATP By similarity
Binding sitei270 – 2701ATP By similarity
Binding sitei300 – 3001ATP By similarity
Binding sitei341 – 3411ATP By similarity
Binding sitei418 – 4181ATP By similarity
Binding sitei424 – 4241ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTVOL273116:GC31-1279-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:TV1261
ORF Names:TVG1298537
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001017: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588DNA ligaseUniRule annotation
PRO_0000059622Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273116.TVN1237.

Structurei

3D structure databases

ProteinModelPortaliQ979A1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
KOiK10747.
OMAiLDPSGYN.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q979A1-1 [UniParc]FASTAAdd to Basket

« Hide

MKFSLVTDAF EKMSKTTKRT ELTEILVELL KSADEDLQSL VYLIEGKLAP    50
DYQGIETQMS DKLIIKALSI VSNIPEEAVS ETYSKLGDIG SVAREIAAKK 100
NMRSLVNEDL TVKYVHDTLM RMAKTSGSGS TKARIDAYVD LALSGTPADL 150
MYITRIITGK LRIGVSDATI LDAIILAFSD EKYSEEIENA YNFHPDLGYI 200
AVQLRLGNLE SVINMGPTPM VPFKVMLAER LRSVDEIVQK MNGKCAFEYK 250
YDGMRTEIHI VDEKVRLFSR GNEETTGQFP DIVKSAKETF HVSSVILDGE 300
AVPYNPETGE LYPFQVISQR RGRKYDLDKV SNEIPITVFL FDIVYINGKD 350
LSKTPYAERR RILEGLFKEN DNFKLAKRIV SSDTGTITKF FNQAIEDGCE 400
GLVAKSMADD SYYKAGARGW LWIKLKRDYQ AQLWDTIDLT VVGAFMGHGR 450
RSGTYGALLL ATYNEKNDTF ETVCKLGSGF TDDVLFSLPK RFAEFVSKEK 500
PARVVSTIEP DVWIYPSIVM EIIGAEITIS PVHTCAFGII EKDAGLSIRF 550
PRFTGKWRDD KKPEDSTTTQ EIIEMYKEQK KTLTEEKS 588
Length:588
Mass (Da):66,218
Last modified:October 1, 2001 - v1
Checksum:i7FC5FC2549F3CD3D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB60403.1.
RefSeqiNP_111756.1. NC_002689.2.
WP_010917495.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB60403; BAB60403; BAB60403.
GeneIDi1441377.
KEGGitvo:TVN1237.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB60403.1 .
RefSeqi NP_111756.1. NC_002689.2.
WP_010917495.1. NC_002689.2.

3D structure databases

ProteinModelPortali Q979A1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273116.TVN1237.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB60403 ; BAB60403 ; BAB60403 .
GeneIDi 1441377.
KEGGi tvo:TVN1237.

Phylogenomic databases

eggNOGi COG1793.
KOi K10747.
OMAi LDPSGYN.

Enzyme and pathway databases

BioCyci TVOL273116:GC31-1279-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Entry informationi

Entry nameiDNLI_THEVO
AccessioniPrimary (citable) accession number: Q979A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2001
Last modified: September 3, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi