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Q978Y8 (SYW_THEVO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:TV1276
ORF Names:TVG1316213
OrganismThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) [Complete proteome] [HAMAP]
Taxonomic identifier273116 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 426426Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136736

Regions

Motif66 – 749"HIGH" region HAMAP-Rule MF_00140
Motif314 – 3185"KMSKS" region HAMAP-Rule MF_00140

Sequences

Sequence LengthMass (Da)Tools
Q978Y8 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 7884711A187319E2

FASTA42648,768
        10         20         30         40         50         60 
MINPWSSSDF FDYERLKKEF GISDQSDNID HFLFRRKVIL GQRGFEYIKY AIDNKIKFNV 

        70         80         90        100        110        120 
MTGLMPSGEM HLGNKSAIDQ VIYFQKLGGS VSIAVADLES YSTRGIPLDK AREIAIEKYI 

       130        140        150        160        170        180 
LNYIAMGLQP CEIYFQSKNK DVQFLSYILG NWTNMNELKA LYGFTDSNDI LHINAPLIQA 

       190        200        210        220        230        240 
ADVLHTQLNN YGGPAPTVVP VGFDQDPHIR LMRDLAKRMR IFNVFYDGGI TVSIKGKGDS 

       250        260        270        280        290        300 
TMPVDQAYEY LSKRFSEVTK DYEYRVVKAK DGKEEDIVRT DIDLAKIGSE FNVFSFIPPS 

       310        320        330        340        350        360 
ATYQKLMKGL KGGKMSSSVP DSLISMNDDV EEAKRKIMRA LTGGRDTEEE QRKLGGEPEK 

       370        380        390        400        410        420 
CPVFDLYNYE IDDDKYVNEV FEECKSGKRM CGYCKREIAD KMSIFLKDIK EKREIAREKL 


SLYIHE 

« Hide

References

[1]"Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium."
Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y., Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T., Yamamoto Y., Aramaki H., Makino K., Suzuki M.
Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000011 Genomic DNA. Translation: BAB60418.1.
RefSeqNP_111772.1. NC_002689.2.

3D structure databases

ProteinModelPortalQ978Y8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273116.TVN1253.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB60418; BAB60418; BAB60418.
GeneID1441393.
KEGGtvo:TVN1253.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0180.
KOK01867.
OMASIYHRFM.

Enzyme and pathway databases

BioCycTVOL273116:GC31-1296-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 2 hits.
HAMAPMF_00140_A. Trp_tRNA_synth_A.
InterProIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 2 hits.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
ProtoNetSearch...

Entry information

Entry nameSYW_THEVO
AccessionPrimary (citable) accession number: Q978Y8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: October 1, 2001
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries