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Q978Y8

- SYW_THEVO

UniProt

Q978Y8 - SYW_THEVO

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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTVOL273116:GC31-1296-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:TV1276
ORF Names:TVG1316213
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001017: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Tryptophan--tRNA ligasePRO_0000136736Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273116.TVN1253.

Structurei

3D structure databases

ProteinModelPortaliQ978Y8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi66 – 749"HIGH" region
Motifi314 – 3185"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0180.
KOiK01867.
OMAiSIYHRFM.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
HAMAPiMF_00140_A. Trp_tRNA_synth_A.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 2 hits.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.

Sequencei

Sequence statusi: Complete.

Q978Y8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MINPWSSSDF FDYERLKKEF GISDQSDNID HFLFRRKVIL GQRGFEYIKY
60 70 80 90 100
AIDNKIKFNV MTGLMPSGEM HLGNKSAIDQ VIYFQKLGGS VSIAVADLES
110 120 130 140 150
YSTRGIPLDK AREIAIEKYI LNYIAMGLQP CEIYFQSKNK DVQFLSYILG
160 170 180 190 200
NWTNMNELKA LYGFTDSNDI LHINAPLIQA ADVLHTQLNN YGGPAPTVVP
210 220 230 240 250
VGFDQDPHIR LMRDLAKRMR IFNVFYDGGI TVSIKGKGDS TMPVDQAYEY
260 270 280 290 300
LSKRFSEVTK DYEYRVVKAK DGKEEDIVRT DIDLAKIGSE FNVFSFIPPS
310 320 330 340 350
ATYQKLMKGL KGGKMSSSVP DSLISMNDDV EEAKRKIMRA LTGGRDTEEE
360 370 380 390 400
QRKLGGEPEK CPVFDLYNYE IDDDKYVNEV FEECKSGKRM CGYCKREIAD
410 420
KMSIFLKDIK EKREIAREKL SLYIHE
Length:426
Mass (Da):48,768
Last modified:October 1, 2001 - v1
Checksum:i7884711A187319E2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB60418.1.
RefSeqiNP_111772.1. NC_002689.2.
WP_010917511.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB60418; BAB60418; BAB60418.
GeneIDi1441393.
KEGGitvo:TVN1253.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB60418.1 .
RefSeqi NP_111772.1. NC_002689.2.
WP_010917511.1. NC_002689.2.

3D structure databases

ProteinModelPortali Q978Y8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273116.TVN1253.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB60418 ; BAB60418 ; BAB60418 .
GeneIDi 1441393.
KEGGi tvo:TVN1253.

Phylogenomic databases

eggNOGi COG0180.
KOi K01867.
OMAi SIYHRFM.

Enzyme and pathway databases

BioCyci TVOL273116:GC31-1296-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 2 hits.
HAMAPi MF_00140_A. Trp_tRNA_synth_A.
InterProi IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 2 hits.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Entry informationi

Entry nameiSYW_THEVO
AccessioniPrimary (citable) accession number: Q978Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: October 1, 2001
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3