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Q978Y8

- SYW_THEVO

UniProt

Q978Y8 - SYW_THEVO

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTVOL273116:GC31-1296-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetaseUniRule annotation
    Short name:
    TrpRSUniRule annotation
    Gene namesi
    Name:trpSUniRule annotation
    Ordered Locus Names:TV1276
    ORF Names:TVG1316213
    OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
    Taxonomic identifieri273116 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
    ProteomesiUP000001017: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 426426Tryptophan--tRNA ligasePRO_0000136736Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273116.TVN1253.

    Structurei

    3D structure databases

    ProteinModelPortaliQ978Y8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi66 – 749"HIGH" region
    Motifi314 – 3185"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0180.
    KOiK01867.
    OMAiSIYHRFM.

    Family and domain databases

    Gene3Di3.40.50.620. 2 hits.
    HAMAPiMF_00140_A. Trp_tRNA_synth_A.
    InterProiIPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 2 hits.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.

    Sequencei

    Sequence statusi: Complete.

    Q978Y8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MINPWSSSDF FDYERLKKEF GISDQSDNID HFLFRRKVIL GQRGFEYIKY    50
    AIDNKIKFNV MTGLMPSGEM HLGNKSAIDQ VIYFQKLGGS VSIAVADLES 100
    YSTRGIPLDK AREIAIEKYI LNYIAMGLQP CEIYFQSKNK DVQFLSYILG 150
    NWTNMNELKA LYGFTDSNDI LHINAPLIQA ADVLHTQLNN YGGPAPTVVP 200
    VGFDQDPHIR LMRDLAKRMR IFNVFYDGGI TVSIKGKGDS TMPVDQAYEY 250
    LSKRFSEVTK DYEYRVVKAK DGKEEDIVRT DIDLAKIGSE FNVFSFIPPS 300
    ATYQKLMKGL KGGKMSSSVP DSLISMNDDV EEAKRKIMRA LTGGRDTEEE 350
    QRKLGGEPEK CPVFDLYNYE IDDDKYVNEV FEECKSGKRM CGYCKREIAD 400
    KMSIFLKDIK EKREIAREKL SLYIHE 426
    Length:426
    Mass (Da):48,768
    Last modified:October 1, 2001 - v1
    Checksum:i7884711A187319E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000011 Genomic DNA. Translation: BAB60418.1.
    RefSeqiNP_111772.1. NC_002689.2.

    Genome annotation databases

    EnsemblBacteriaiBAB60418; BAB60418; BAB60418.
    GeneIDi1441393.
    KEGGitvo:TVN1253.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000011 Genomic DNA. Translation: BAB60418.1 .
    RefSeqi NP_111772.1. NC_002689.2.

    3D structure databases

    ProteinModelPortali Q978Y8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273116.TVN1253.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB60418 ; BAB60418 ; BAB60418 .
    GeneIDi 1441393.
    KEGGi tvo:TVN1253.

    Phylogenomic databases

    eggNOGi COG0180.
    KOi K01867.
    OMAi SIYHRFM.

    Enzyme and pathway databases

    BioCyci TVOL273116:GC31-1296-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 2 hits.
    HAMAPi MF_00140_A. Trp_tRNA_synth_A.
    InterProi IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 2 hits.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

    Entry informationi

    Entry nameiSYW_THEVO
    AccessioniPrimary (citable) accession number: Q978Y8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3