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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTVOL273116:G1G3C-1363-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:TV1276
ORF Names:TVG1316213
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001017 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367361 – 426Tryptophan--tRNA ligaseAdd BLAST426

Proteomic databases

PRIDEiQ978Y8

Interactioni

Protein-protein interaction databases

STRINGi273116.TVN1253

Structurei

3D structure databases

ProteinModelPortaliQ978Y8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi66 – 74"HIGH" region9
Motifi314 – 318"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01887 Archaea
COG0180 LUCA
KOiK01867
OMAiADILHPQ
OrthoDBiPOG093Z044X

Family and domain databases

Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00140_A Trp_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR020653 Tryptophan-tRNA-ligase_arc
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 2 hits
PRINTSiPR01039 TRNASYNTHTRP

Sequencei

Sequence statusi: Complete.

Q978Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINPWSSSDF FDYERLKKEF GISDQSDNID HFLFRRKVIL GQRGFEYIKY
60 70 80 90 100
AIDNKIKFNV MTGLMPSGEM HLGNKSAIDQ VIYFQKLGGS VSIAVADLES
110 120 130 140 150
YSTRGIPLDK AREIAIEKYI LNYIAMGLQP CEIYFQSKNK DVQFLSYILG
160 170 180 190 200
NWTNMNELKA LYGFTDSNDI LHINAPLIQA ADVLHTQLNN YGGPAPTVVP
210 220 230 240 250
VGFDQDPHIR LMRDLAKRMR IFNVFYDGGI TVSIKGKGDS TMPVDQAYEY
260 270 280 290 300
LSKRFSEVTK DYEYRVVKAK DGKEEDIVRT DIDLAKIGSE FNVFSFIPPS
310 320 330 340 350
ATYQKLMKGL KGGKMSSSVP DSLISMNDDV EEAKRKIMRA LTGGRDTEEE
360 370 380 390 400
QRKLGGEPEK CPVFDLYNYE IDDDKYVNEV FEECKSGKRM CGYCKREIAD
410 420
KMSIFLKDIK EKREIAREKL SLYIHE
Length:426
Mass (Da):48,768
Last modified:October 1, 2001 - v1
Checksum:i7884711A187319E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA Translation: BAB60418.1
RefSeqiWP_010917511.1, NC_002689.2

Genome annotation databases

EnsemblBacteriaiBAB60418; BAB60418; BAB60418
GeneIDi1441393
KEGGitvo:TVG1316213

Similar proteinsi

Entry informationi

Entry nameiSYW_THEVO
AccessioniPrimary (citable) accession number: Q978Y8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: October 1, 2001
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health