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Q978F3

- PGMI_THEVO

UniProt

Q978F3 - PGMI_THEVO

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Protein

Bifunctional phosphoglucose/phosphomannose isomerase

Gene

TV1464

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency.By similarity

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.
D-mannose 6-phosphate = D-fructose 6-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei196 – 1961Proton acceptorBy similarity
Active sitei212 – 2121Proton donorBy similarity
Active sitei300 – 3001Proton acceptorBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glucose-6-phosphate isomerase activity Source: UniProtKB-EC
  3. mannose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciTVOL273116:GC31-1487-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional phosphoglucose/phosphomannose isomerase
Alternative name(s):
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Phosphoglucose isomerase
Short name:
PGI
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Ordered Locus Names:TV1464
ORF Names:TVG1514630
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001017: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Bifunctional phosphoglucose/phosphomannose isomerasePRO_0000227798Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi273116.TVN1438.

Structurei

3D structure databases

ProteinModelPortaliQ978F3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 147132SISPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PGI/PMI family.Curated
Contains 1 SIS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0166.
KOiK15916.
OMAiIAERWKG.

Family and domain databases

InterProiIPR011857. Glu6P/Mann6P_isomerase.
IPR019490. Glu6P/Mann6P_isomerase_C.
IPR001347. SIS.
[Graphical view]
PfamiPF10432. bact-PGI_C. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02128. G6PI_arch. 1 hit.
PROSITEiPS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q978F3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQFSEELLTL KDQVRFDKSF KVGKYDKIVI AGMGGSGIAG RIFSEIYDEK
60 70 80 90 100
PVFLVDDYDI PSFVDDKTEF IAISYSGNTE ETISASEEAA KKHANVHAIT
110 120 130 140 150
SGGSLSKMGF DTIIIPSGLQ PRSSIGYLLM PLVNTFIKPK IGDVDEAYRL
160 170 180 190 200
LSETDKDNEE EKSIASEIYN GEHIPVIYGS RPFRAIAYRW KTQFNENAKV
210 220 230 240 250
LAYSNYFSEL NHNDTMPLKD TYRKDEFYFL VFRSDDSRFS KRITVTEKIT
260 270 280 290 300
GNSFRMVDVR GSSLLAKLFY LIHFGDYLTY HLAELRGVDP QDVSLIEKLK

KEIA
Length:304
Mass (Da):34,558
Last modified:October 1, 2001 - v1
Checksum:i09BD551B9A286EA6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB60606.1.
RefSeqiNP_111957.1. NC_002689.2.
WP_010917694.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB60606; BAB60606; BAB60606.
GeneIDi1442154.
KEGGitvo:TVN1438.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB60606.1 .
RefSeqi NP_111957.1. NC_002689.2.
WP_010917694.1. NC_002689.2.

3D structure databases

ProteinModelPortali Q978F3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273116.TVN1438.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB60606 ; BAB60606 ; BAB60606 .
GeneIDi 1442154.
KEGGi tvo:TVN1438.

Phylogenomic databases

eggNOGi COG0166.
KOi K15916.
OMAi IAERWKG.

Enzyme and pathway databases

BioCyci TVOL273116:GC31-1487-MONOMER.

Family and domain databases

InterProi IPR011857. Glu6P/Mann6P_isomerase.
IPR019490. Glu6P/Mann6P_isomerase_C.
IPR001347. SIS.
[Graphical view ]
Pfami PF10432. bact-PGI_C. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02128. G6PI_arch. 1 hit.
PROSITEi PS51464. SIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Entry informationi

Entry nameiPGMI_THEVO
AccessioniPrimary (citable) accession number: Q978F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2001
Last modified: October 1, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3