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Q978F3 (PGMI_THEVO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional phosphoglucose/phosphomannose isomerase
Alternative name(s):
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Mannose-6-phosphate isomerase
EC=5.3.1.8
Phosphoglucose isomerase
Short name=PGI
Phosphomannose isomerase
Short name=PMI
Gene names
Ordered Locus Names:TV1464
ORF Names:TVG1514630
OrganismThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) [Complete proteome] [HAMAP]
Taxonomic identifier273116 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency By similarity.

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate.

D-mannose 6-phosphate = D-fructose 6-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the PGI/PMI family.

Contains 1 SIS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 304304Bifunctional phosphoglucose/phosphomannose isomerase
PRO_0000227798

Regions

Domain16 – 147132SIS

Sites

Active site1961Proton acceptor By similarity
Active site2121Proton donor By similarity
Active site3001Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q978F3 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 09BD551B9A286EA6

FASTA30434,558
        10         20         30         40         50         60 
MQFSEELLTL KDQVRFDKSF KVGKYDKIVI AGMGGSGIAG RIFSEIYDEK PVFLVDDYDI 

        70         80         90        100        110        120 
PSFVDDKTEF IAISYSGNTE ETISASEEAA KKHANVHAIT SGGSLSKMGF DTIIIPSGLQ 

       130        140        150        160        170        180 
PRSSIGYLLM PLVNTFIKPK IGDVDEAYRL LSETDKDNEE EKSIASEIYN GEHIPVIYGS 

       190        200        210        220        230        240 
RPFRAIAYRW KTQFNENAKV LAYSNYFSEL NHNDTMPLKD TYRKDEFYFL VFRSDDSRFS 

       250        260        270        280        290        300 
KRITVTEKIT GNSFRMVDVR GSSLLAKLFY LIHFGDYLTY HLAELRGVDP QDVSLIEKLK 


KEIA 

« Hide

References

[1]"Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium."
Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y., Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T., Yamamoto Y., Aramaki H., Makino K., Suzuki M.
Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000011 Genomic DNA. Translation: BAB60606.1.
RefSeqNP_111957.1. NC_002689.2.

3D structure databases

ProteinModelPortalQ978F3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273116.TVN1438.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB60606; BAB60606; BAB60606.
GeneID1442154.
KEGGtvo:TVN1438.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
KOK15916.
OMAIAERWKG.

Enzyme and pathway databases

BioCycTVOL273116:GC31-1487-MONOMER.

Family and domain databases

InterProIPR011857. Glu6P/Mann6P_isomerase.
IPR019490. Glu6P/Mann6P_isomerase_C.
IPR001347. SIS.
[Graphical view]
PfamPF10432. bact-PGI_C. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
TIGRFAMsTIGR02128. G6PI_arch. 1 hit.
PROSITEPS51464. SIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGMI_THEVO
AccessionPrimary (citable) accession number: Q978F3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2001
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families