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Protein

Bifunctional phosphoglucose/phosphomannose isomerase

Gene

TV1464

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency.By similarity

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.
D-mannose 6-phosphate = D-fructose 6-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei196Proton acceptorBy similarity1
Active sitei212Proton donorBy similarity1
Active sitei300Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Multifunctional enzyme

Enzyme and pathway databases

BioCyciTVOL273116:G1G3C-1561-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional phosphoglucose/phosphomannose isomerase
Alternative name(s):
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Phosphoglucose isomerase
Short name:
PGI
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Ordered Locus Names:TV1464
ORF Names:TVG1514630
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001017 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002277981 – 304Bifunctional phosphoglucose/phosphomannose isomeraseAdd BLAST304

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi273116.TVN1438

Structurei

3D structure databases

ProteinModelPortaliQ978F3
SMRiQ978F3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 147SISPROSITE-ProRule annotationAdd BLAST132

Sequence similaritiesi

Belongs to the PGI/PMI family.Curated

Phylogenomic databases

eggNOGiarCOG00052 Archaea
COG0166 LUCA
KOiK15916
OMAiPELNHNE
OrthoDBiPOG093Z0B0H

Family and domain databases

CDDicd05017 SIS_PGI_PMI_1, 1 hit
cd05637 SIS_PGI_PMI_2, 1 hit
InterProiView protein in InterPro
IPR019490 Glu6P/Mann6P_isomerase_C
IPR011857 PGI/PMI
IPR001347 SIS
IPR035484 SIS_PGI/PMI_1
PfamiView protein in Pfam
PF10432 bact-PGI_C, 1 hit
PF01380 SIS, 1 hit
TIGRFAMsiTIGR02128 G6PI_arch, 1 hit
PROSITEiView protein in PROSITE
PS51464 SIS, 1 hit

Sequencei

Sequence statusi: Complete.

Q978F3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFSEELLTL KDQVRFDKSF KVGKYDKIVI AGMGGSGIAG RIFSEIYDEK
60 70 80 90 100
PVFLVDDYDI PSFVDDKTEF IAISYSGNTE ETISASEEAA KKHANVHAIT
110 120 130 140 150
SGGSLSKMGF DTIIIPSGLQ PRSSIGYLLM PLVNTFIKPK IGDVDEAYRL
160 170 180 190 200
LSETDKDNEE EKSIASEIYN GEHIPVIYGS RPFRAIAYRW KTQFNENAKV
210 220 230 240 250
LAYSNYFSEL NHNDTMPLKD TYRKDEFYFL VFRSDDSRFS KRITVTEKIT
260 270 280 290 300
GNSFRMVDVR GSSLLAKLFY LIHFGDYLTY HLAELRGVDP QDVSLIEKLK

KEIA
Length:304
Mass (Da):34,558
Last modified:October 1, 2001 - v1
Checksum:i09BD551B9A286EA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA Translation: BAB60606.1
RefSeqiWP_010917694.1, NC_002689.2

Genome annotation databases

EnsemblBacteriaiBAB60606; BAB60606; BAB60606
GeneIDi1442154
KEGGitvo:TVG1514630

Similar proteinsi

Entry informationi

Entry nameiPGMI_THEVO
AccessioniPrimary (citable) accession number: Q978F3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2001
Last modified: April 25, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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