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Reviewed, UniProtKB/Swiss-Prot Q978F3 (PGMI_THEVO)

Last modified June 15, 2010. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
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Names and originHide

Protein namesRecommended name:
Bifunctional phosphoglucose/phosphomannose isomerase
Alternative name(s):
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Phosphoglucose isomerase
Short name=PGI
Mannose-6-phosphate isomerase
EC=5.3.1.8
Phosphomannose isomerase
Short name=PMI
Gene names
Ordered Locus Names:TV1464
ORF Names:TVG1514630
OrganismThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / IFO 15438 / JCM 9571 / GSS1) [Complete proteome] [HAMAP]
Taxonomic identifier273116 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
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Protein attributesHide

Sequence length304 AA.
Sequence statusComplete.
Protein existenceInferred from homology.
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General annotation (Comments)Hide

Function

Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency By similarity.

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate.

D-mannose 6-phosphate = D-fructose 6-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the PGI/PMI family.

Contains 1 SIS domain.

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Sequence annotation (Features)Hide

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 304304Bifunctional phosphoglucose/phosphomannose isomerase
PRO_0000227798

Regions

Domain16 – 147132SIS

Sites

Active site1961Proton acceptor By similarity
Active site2121Proton donor By similarity
Active site3001Proton acceptor By similarity
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SequencesHide

Sequence LengthMass (Da)Tools
Q978F3-1 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 09BD551B9A286EA6

FASTA30434,558
        10         20         30         40         50         60 
MQFSEELLTL KDQVRFDKSF KVGKYDKIVI AGMGGSGIAG RIFSEIYDEK PVFLVDDYDI 

        70         80         90        100        110        120 
PSFVDDKTEF IAISYSGNTE ETISASEEAA KKHANVHAIT SGGSLSKMGF DTIIIPSGLQ 

       130        140        150        160        170        180 
PRSSIGYLLM PLVNTFIKPK IGDVDEAYRL LSETDKDNEE EKSIASEIYN GEHIPVIYGS 

       190        200        210        220        230        240 
RPFRAIAYRW KTQFNENAKV LAYSNYFSEL NHNDTMPLKD TYRKDEFYFL VFRSDDSRFS 

       250        260        270        280        290        300 
KRITVTEKIT GNSFRMVDVR GSSLLAKLFY LIHFGDYLTY HLAELRGVDP QDVSLIEKLK 


KEIA 

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ReferencesHide

[1]"Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium."
Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y., Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T., Yamamoto Y., Aramaki H., Makino K., Suzuki M.
Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000) [PubMed: 11121031] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
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Cross-referencesHide

Sequence databases

EMBL
GenBank
DDBJ
BA000011 Genomic DNA. Translation: BAB60606.1.
RefSeqNP_111957.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1442154.
GenomeReviewsGene locus TV1464 in contig BA000011_GR.
KEGGtvo:TVN1438.
NMPDRfig|273116.1.peg.1438.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG507538.
OMAGNTEETL.
ProtClustDBPRK08674.

Enzyme and pathway databases

BRENDA5.3.1.8. 256346.
5.3.1.9. 256346.

Family and domain databases

InterProIPR011857. Glu6P/Mann6P_isomerase.
IPR019490. Glu6P/Mann6P_isomerase_C.
IPR001347. SIS.
[Graphical view]
PfamPF10432. bact-PGI_C. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
TIGRFAMsTIGR02128. G6PI_arch. 1 hit.
PROSITEPS51464. SIS. 1 hit.
[Graphical view]
ProtoNetSearch...
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Entry informationHide

Entry namePGMI_THEVO
AccessionPrimary (citable) accession number: Q978F3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2001
Last modified: June 15, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)
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Relevant documentsHide

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents