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Q977X5 (PYRF_METTE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
OrganismMethanosarcina thermophila
Taxonomic identifier2210 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina

Protein attributes

Sequence length215 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity. HAMAP-Rule MF_01200

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01200

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01200

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01200

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Sequence caution

The sequence AAK49975.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 215215Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01200
PRO_0000134613

Regions

Region54 – 6310Substrate binding By similarity
Region164 – 17411Substrate binding By similarity

Sites

Active site561Proton donor By similarity
Binding site61Substrate By similarity
Binding site281Substrate By similarity
Binding site1111Substrate By similarity
Binding site1871Substrate; via amide nitrogen By similarity
Binding site1881Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q977X5 [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: 999361ABDA5F736B

FASTA21523,115
        10         20         30         40         50         60 
MILALDVTDR DEALKIAEDV WEFVDAIKVG YPLILTTGLG IIRELAEFAP VIADFKVADI 

        70         80         90        100        110        120 
PNTNRLICDQ VFEAGADAVI VQGFTGRDSL DACIEIASEY RKDVFVVSEM SHPGGAEFLQ 

       130        140        150        160        170        180 
PAAESIAKMA LEAGAFGLVA PATRPERVRK IRRIIGDKLT IISPGVGAQG GKASDVIAAG 

       190        200        210 
TDWVIVGRSI YKAESPKEAA REIAEEIQAE LRGEY 

« Hide

References

[1]"A putative pyrF gene cloned from Methanosarcina thermophila."
Apolinario-Smith E.E., Sowers K.R.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF358260 Genomic DNA. Translation: AAK49975.1. Different initiation.

3D structure databases

ProteinModelPortalQ977X5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01200_A. OMPdecase_type1_A.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_METTE
AccessionPrimary (citable) accession number: Q977X5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: February 19, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways