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Q977W1

- Q977W1_9EURY

UniProt

Q977W1 - Q977W1_9EURY

Protein
Submitted name:

Topoisomerase V

Gene

top5

Organism
Methanopyrus kandleri
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371Phosphate 1Imported
    Binding sitei42 – 421Phosphate 2Imported
    Binding sitei47 – 471Phosphate 1Imported
    Binding sitei108 – 1081Phosphate 3Imported
    Binding sitei131 – 1311Phosphate 3Imported
    Binding sitei135 – 1351Phosphate 1Imported
    Binding sitei144 – 1441Phosphate 3Imported
    Binding sitei293 – 2931Phosphate 3Imported
    Binding sitei322 – 3221Phosphate 3Imported

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. isomerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. DNA repair Source: InterPro

    Keywords - Molecular functioni

    IsomeraseImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Topoisomerase VImported
    Gene namesi
    Name:top5Imported
    OrganismiMethanopyrus kandleriImported
    Taxonomic identifieri2320 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus

    Interactioni

    Protein-protein interaction databases

    STRINGi190192.MK1436.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CSBX-ray2.30A/B1-519[»]
    2CSDX-ray2.90A/B1-519[»]
    3M6KX-ray2.60A/B1-380[»]
    3M6ZX-ray1.40A/B1-380[»]
    3M7DX-ray1.82A1-380[»]
    3M7GX-ray2.40A1-269[»]
    ProteinModelPortaliQ977W1.
    SMRiQ977W1. Positions 3-519.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ977W1.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni270 – 2712Phosphate 2 bindingImported

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR010994. RuvA_2-like.
    IPR024065. TopoV_catalytic_domain.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    SMARTiSM00278. HhH1. 11 hits.
    [Graphical view]
    SUPFAMiSSF140979. SSF140979. 2 hits.
    SSF47781. SSF47781. 6 hits.

    Sequencei

    Sequence statusi: Complete.

    Q977W1-1 [UniParc]FASTAAdd to Basket

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    MALVYDAEFV GSEREFEEER ETFLKGVKAY DGVLATRYLM ERSSSAKNDE    50
    ELLELHQNFI LLTGSYACSI DPTEDRYQNV IVRGVNFDER VQRLSTGGSP 100
    ARYAIVYRRG WRAIAKALDI DEEDVPAIEV RAVKRNPLQP ALYRILVRYG 150
    RVDLMPVTVD EVPPEMAGEF ERLIERYDVP IDEKEERILE ILRENPWTPH 200
    DEIARRLGLS VSEVEGEKDP ESSGIYSLWS RVVVNIEYDE RTAKRHVKRR 250
    DRLLEELYEH LEELSERYLR HPLTRRWIVE HKRDIMRRYL EQRIVECALK 300
    LQDRYGIRED VALCLARAFD GSISMIATTP YRTLKDVCPD LTLEEAKSVN 350
    RTLATLIDEH GLSPDAADEL IEHFESIAGI LATDLEEIER MYEEGRLSEE 400
    AYRAAVEIQL AELTKKEGVG RKTAERLLRA FGNPERVKQL AREFEIEKLA 450
    SVEGVGERVL RSLVPGYASL ISIRGIDRER AERLLKKYGG YSKVREAGVE 500
    ELREDGLTDA QIRELKGLKT LESIVGDLEK ADELKRKYGS ASAVRRLPVE 550
    ELRELGFSDD EIAEIKGIPK KLREAFDLET AAELYERYGS LKEIGRRLSY 600
    DDLLELGATP KAAAEIKGPE FKFLLNIEGV GPKLAERILE AVDYDLERLA 650
    SLNPEELAEK VEGLGEELAE RVVYAARERV ESRRKSGRQE RSEEEWKEWL 700
    ERKVGEGRAR RLIEYFGSAG EVGKLVENAE VSKLLEVPGI GDEAVARLVP 750
    GYKTLRDAGL TPAEAERVLK RYGSVSKVQE GATPDELREL GLGDAKIARI 800
    LGLRSLVNKR LDVDTAYELK RRYGSVSAVR KAPVKELREL GLSDRKIARI 850
    KGIPETMLQV RGMSVEKAER LLERFDTWTK VKEAPVSELV RVPGVGLSLV 900
    KEIKAQVDPA WKALLDVKGV SPELADRLVE ELGSPYRVLT AKKSDLMRVE 950
    RVGPKLAERI RAAGKRYVEE RRSRRERIRR KLRG 984
    Length:984
    Mass (Da):112,207
    Last modified:December 1, 2001 - v1
    Checksum:i63ABCC55177571D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF311944 Genomic DNA. Translation: AAK60014.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF311944 Genomic DNA. Translation: AAK60014.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CSB X-ray 2.30 A/B 1-519 [» ]
    2CSD X-ray 2.90 A/B 1-519 [» ]
    3M6K X-ray 2.60 A/B 1-380 [» ]
    3M6Z X-ray 1.40 A/B 1-380 [» ]
    3M7D X-ray 1.82 A 1-380 [» ]
    3M7G X-ray 2.40 A 1-269 [» ]
    ProteinModelPortali Q977W1.
    SMRi Q977W1. Positions 3-519.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 190192.MK1436.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q977W1.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR010994. RuvA_2-like.
    IPR024065. TopoV_catalytic_domain.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    SMARTi SM00278. HhH1. 11 hits.
    [Graphical view ]
    SUPFAMi SSF140979. SSF140979. 2 hits.
    SSF47781. SSF47781. 6 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
    2. "Structure of the N-terminal fragment of topoisomerase V reveals a new family of topoisomerases."
      Taneja B., Patel A., Slesarev A., Mondragon A.
      EMBO J. 25:398-408(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 1-519.
    3. "Structures of minimal catalytic fragments of topoisomerase V reveals conformational changes relevant for DNA binding."
      Rajan R., Taneja B., Mondragon A.
      Structure 18:829-838(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 1-380.

    Entry informationi

    Entry nameiQ977W1_9EURY
    AccessioniPrimary (citable) accession number: Q977W1
    Secondary accession number(s): Q7LWW1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3