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Q977W1

- Q977W1_9EURY

UniProt

Q977W1 - Q977W1_9EURY

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Protein
Submitted name:

Topoisomerase V

Gene

top5

Organism
Methanopyrus kandleri
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. isomerase activity Source: UniProtKB-KW

GO - Biological processi

  1. DNA repair Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Topoisomerase VImported
Gene namesi
Name:top5Imported
OrganismiMethanopyrus kandleriImported
Taxonomic identifieri2320 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus

Interactioni

Protein-protein interaction databases

STRINGi190192.MK1436.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CSBX-ray2.30A/B1-519[»]
2CSDX-ray2.90A/B1-519[»]
3M6KX-ray2.60A/B1-380[»]
3M6ZX-ray1.40A/B1-380[»]
3M7DX-ray1.82A1-380[»]
3M7GX-ray2.40A1-269[»]
ProteinModelPortaliQ977W1.
SMRiQ977W1. Positions 3-519.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ977W1.

Family & Domainsi

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR024065. TopoV_catalytic_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
SMARTiSM00278. HhH1. 11 hits.
[Graphical view]
SUPFAMiSSF140979. SSF140979. 2 hits.
SSF47781. SSF47781. 6 hits.

Sequencei

Sequence statusi: Complete.

Q977W1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALVYDAEFV GSEREFEEER ETFLKGVKAY DGVLATRYLM ERSSSAKNDE
60 70 80 90 100
ELLELHQNFI LLTGSYACSI DPTEDRYQNV IVRGVNFDER VQRLSTGGSP
110 120 130 140 150
ARYAIVYRRG WRAIAKALDI DEEDVPAIEV RAVKRNPLQP ALYRILVRYG
160 170 180 190 200
RVDLMPVTVD EVPPEMAGEF ERLIERYDVP IDEKEERILE ILRENPWTPH
210 220 230 240 250
DEIARRLGLS VSEVEGEKDP ESSGIYSLWS RVVVNIEYDE RTAKRHVKRR
260 270 280 290 300
DRLLEELYEH LEELSERYLR HPLTRRWIVE HKRDIMRRYL EQRIVECALK
310 320 330 340 350
LQDRYGIRED VALCLARAFD GSISMIATTP YRTLKDVCPD LTLEEAKSVN
360 370 380 390 400
RTLATLIDEH GLSPDAADEL IEHFESIAGI LATDLEEIER MYEEGRLSEE
410 420 430 440 450
AYRAAVEIQL AELTKKEGVG RKTAERLLRA FGNPERVKQL AREFEIEKLA
460 470 480 490 500
SVEGVGERVL RSLVPGYASL ISIRGIDRER AERLLKKYGG YSKVREAGVE
510 520 530 540 550
ELREDGLTDA QIRELKGLKT LESIVGDLEK ADELKRKYGS ASAVRRLPVE
560 570 580 590 600
ELRELGFSDD EIAEIKGIPK KLREAFDLET AAELYERYGS LKEIGRRLSY
610 620 630 640 650
DDLLELGATP KAAAEIKGPE FKFLLNIEGV GPKLAERILE AVDYDLERLA
660 670 680 690 700
SLNPEELAEK VEGLGEELAE RVVYAARERV ESRRKSGRQE RSEEEWKEWL
710 720 730 740 750
ERKVGEGRAR RLIEYFGSAG EVGKLVENAE VSKLLEVPGI GDEAVARLVP
760 770 780 790 800
GYKTLRDAGL TPAEAERVLK RYGSVSKVQE GATPDELREL GLGDAKIARI
810 820 830 840 850
LGLRSLVNKR LDVDTAYELK RRYGSVSAVR KAPVKELREL GLSDRKIARI
860 870 880 890 900
KGIPETMLQV RGMSVEKAER LLERFDTWTK VKEAPVSELV RVPGVGLSLV
910 920 930 940 950
KEIKAQVDPA WKALLDVKGV SPELADRLVE ELGSPYRVLT AKKSDLMRVE
960 970 980
RVGPKLAERI RAAGKRYVEE RRSRRERIRR KLRG
Length:984
Mass (Da):112,207
Last modified:December 1, 2001 - v1
Checksum:i63ABCC55177571D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311944 Genomic DNA. Translation: AAK60014.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311944 Genomic DNA. Translation: AAK60014.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CSB X-ray 2.30 A/B 1-519 [» ]
2CSD X-ray 2.90 A/B 1-519 [» ]
3M6K X-ray 2.60 A/B 1-380 [» ]
3M6Z X-ray 1.40 A/B 1-380 [» ]
3M7D X-ray 1.82 A 1-380 [» ]
3M7G X-ray 2.40 A 1-269 [» ]
ProteinModelPortali Q977W1.
SMRi Q977W1. Positions 3-519.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190192.MK1436.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q977W1.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR024065. TopoV_catalytic_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
SMARTi SM00278. HhH1. 11 hits.
[Graphical view ]
SUPFAMi SSF140979. SSF140979. 2 hits.
SSF47781. SSF47781. 6 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. "Structure of the N-terminal fragment of topoisomerase V reveals a new family of topoisomerases."
    Taneja B., Patel A., Slesarev A., Mondragon A.
    EMBO J. 25:398-408(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 1-519, ACTIVE SITE.
  3. "Structures of minimal catalytic fragments of topoisomerase V reveals conformational changes relevant for DNA binding."
    Rajan R., Taneja B., Mondragon A.
    Structure 18:829-838(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 1-380, ACTIVE SITE.

Entry informationi

Entry nameiQ977W1_9EURY
AccessioniPrimary (citable) accession number: Q977W1
Secondary accession number(s): Q7LWW1
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3