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Q977W1 (Q977W1_9EURY) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:top5 EMBL AAK60014.1
OrganismMethanopyrus kandleri EMBL AAK60014.1
Taxonomic identifier2320 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus

Protein attributes

Sequence length984 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Ontologies

Keywords
   LigandChloride PDB 3M6Z
   Molecular functionIsomerase EMBL AAK60014.1
   Technical term3D-structure PDB 2CSD PDB 2CSB PDB 3M6Z PDB 3M6K PDB 3M7G PDB 3M7D
Gene Ontology (GO)
   Biological_processDNA repair

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: InterPro

isomerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region270 – 2712Phosphate 2 binding PDB 3M6Z

Sites

Binding site141Chloride 2; via amide nitrogen PDB 3M6Z
Binding site371Phosphate 1 PDB 3M6Z
Binding site421Phosphate 2 PDB 3M6Z
Binding site471Phosphate 1 PDB 3M6Z
Binding site1081Phosphate 3 PDB 3M6Z
Binding site1161Chloride 1 PDB 3M6Z
Binding site1311Phosphate 3 PDB 3M6Z
Binding site1351Phosphate 1 PDB 3M6Z
Binding site1441Phosphate 3 PDB 3M6Z
Binding site2931Phosphate 3 PDB 3M6Z
Binding site3221Phosphate 3 PDB 3M6Z

Sequences

Sequence LengthMass (Da)Tools
Q977W1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 63ABCC55177571D6

FASTA984112,207
        10         20         30         40         50         60 
MALVYDAEFV GSEREFEEER ETFLKGVKAY DGVLATRYLM ERSSSAKNDE ELLELHQNFI 

        70         80         90        100        110        120 
LLTGSYACSI DPTEDRYQNV IVRGVNFDER VQRLSTGGSP ARYAIVYRRG WRAIAKALDI 

       130        140        150        160        170        180 
DEEDVPAIEV RAVKRNPLQP ALYRILVRYG RVDLMPVTVD EVPPEMAGEF ERLIERYDVP 

       190        200        210        220        230        240 
IDEKEERILE ILRENPWTPH DEIARRLGLS VSEVEGEKDP ESSGIYSLWS RVVVNIEYDE 

       250        260        270        280        290        300 
RTAKRHVKRR DRLLEELYEH LEELSERYLR HPLTRRWIVE HKRDIMRRYL EQRIVECALK 

       310        320        330        340        350        360 
LQDRYGIRED VALCLARAFD GSISMIATTP YRTLKDVCPD LTLEEAKSVN RTLATLIDEH 

       370        380        390        400        410        420 
GLSPDAADEL IEHFESIAGI LATDLEEIER MYEEGRLSEE AYRAAVEIQL AELTKKEGVG 

       430        440        450        460        470        480 
RKTAERLLRA FGNPERVKQL AREFEIEKLA SVEGVGERVL RSLVPGYASL ISIRGIDRER 

       490        500        510        520        530        540 
AERLLKKYGG YSKVREAGVE ELREDGLTDA QIRELKGLKT LESIVGDLEK ADELKRKYGS 

       550        560        570        580        590        600 
ASAVRRLPVE ELRELGFSDD EIAEIKGIPK KLREAFDLET AAELYERYGS LKEIGRRLSY 

       610        620        630        640        650        660 
DDLLELGATP KAAAEIKGPE FKFLLNIEGV GPKLAERILE AVDYDLERLA SLNPEELAEK 

       670        680        690        700        710        720 
VEGLGEELAE RVVYAARERV ESRRKSGRQE RSEEEWKEWL ERKVGEGRAR RLIEYFGSAG 

       730        740        750        760        770        780 
EVGKLVENAE VSKLLEVPGI GDEAVARLVP GYKTLRDAGL TPAEAERVLK RYGSVSKVQE 

       790        800        810        820        830        840 
GATPDELREL GLGDAKIARI LGLRSLVNKR LDVDTAYELK RRYGSVSAVR KAPVKELREL 

       850        860        870        880        890        900 
GLSDRKIARI KGIPETMLQV RGMSVEKAER LLERFDTWTK VKEAPVSELV RVPGVGLSLV 

       910        920        930        940        950        960 
KEIKAQVDPA WKALLDVKGV SPELADRLVE ELGSPYRVLT AKKSDLMRVE RVGPKLAERI 

       970        980 
RAAGKRYVEE RRSRRERIRR KLRG 

« Hide

References

[1]"A type IB topoisomerase with DNA repair activities."
Belova G.I., Prasad R., Kozyavkin S.A., Lake J.A., Wilson S.H., Slesarev A.I.
Proc. Natl. Acad. Sci. U.S.A. 98:6015-6020(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Structure of the N-terminal fragment of topoisomerase V reveals a new family of topoisomerases."
Taneja B., Patel A., Slesarev A., Mondragon A.
EMBO J. 25:398-408(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 1-519.
[3]"Structures of minimal catalytic fragments of topoisomerase V reveals conformational changes relevant for DNA binding."
Rajan R., Taneja B., Mondragon A.
Structure 18:829-838(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 1-380 IN COMPLEX WITH CHLORIDE AND PHOSPHATE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF311944 Genomic DNA. Translation: AAK60014.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2CSBX-ray2.30A/B1-519[»]
2CSDX-ray2.90A/B1-519[»]
3M6KX-ray2.60A/B1-380[»]
3M6ZX-ray1.40A/B1-380[»]
3M7DX-ray1.82A1-380[»]
3M7GX-ray2.40A1-269[»]
ProteinModelPortalQ977W1.
SMRQ977W1. Positions 3-519.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190192.MK1436.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR024065. TopoV_catalytic_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
SMARTSM00278. HhH1. 11 hits.
[Graphical view]
SUPFAMSSF140979. SSF140979. 2 hits.
SSF47781. SSF47781. 6 hits.
ProtoNetSearch...

Other

EvolutionaryTraceQ977W1.

Entry information

Entry nameQ977W1_9EURY
AccessionPrimary (citable) accession number: Q977W1
Secondary accession number(s): Q7LWW1
Entry history
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)