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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTOK273063:G1G3D-196-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:STK_01690
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367341 – 381Tryptophan--tRNA ligaseAdd BLAST381

Interactioni

Protein-protein interaction databases

STRINGi273063.ST0169

Structurei

3D structure databases

ProteinModelPortaliQ976M1
SMRiQ976M1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi82 – 90"HIGH" region9
Motifi254 – 258"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01887 Archaea
COG0180 LUCA
HOGENOMiHOG000224742
KOiK01867
OMAiADILHPQ
OrthoDBiPOG093Z034D

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00140_A Trp_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR020653 Tryptophan-tRNA-ligase_arc
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

Q976M1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQDFNVTPW EVKGKVDYDK LIVQFGTQKI TSELKEKIKS IINDELHVML
60 70 80 90 100
RRDVFFSHRD LDLVLKDYQD GKGFFLYTGR APSLGMHIGH LIPFIFTKWL
110 120 130 140 150
QDKFNVNLYI EITDDEKFMR NPEYTLDQTR QWAYDNILDI IAVGFNPDKT
160 170 180 190 200
FIFQDTEYIR NMYPIAIKIA KKLTFSEVRA TFGLDTSSNI GIIWYPALQI
210 220 230 240 250
APTMFEKRRC LIPAGIDQDP YWRLQRDIAE SLGYYKAAQI HSKFLPPLTG
260 270 280 290 300
PEGKMSSSQP ETAIYLTDDP KTVERKIMKY AFSGGQPTIE LHRKYGGNPD
310 320 330 340 350
IDVSFQWLYM FFEPDDNKIK KIEEDYRSGA LLTGELKQIL IEKLNDFLEE
360 370 380
HRQKREEAKK LVNVFKYDGE LAREMWRKIH E
Length:381
Mass (Da):44,718
Last modified:April 16, 2002 - v2
Checksum:i109F5A56AF7D7159
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA Translation: BAK54171.1
RefSeqiWP_010978108.1, NC_003106.2

Genome annotation databases

EnsemblBacteriaiBAK54171; BAK54171; STK_01690
GeneIDi1458052
KEGGisto:STK_01690
PATRICifig|273063.9.peg.208

Similar proteinsi

Entry informationi

Entry nameiSYW_SULTO
AccessioniPrimary (citable) accession number: Q976M1
Secondary accession number(s): F9VMM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: April 16, 2002
Last modified: March 28, 2018
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health