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Protein

Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)

Gene

uppS

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401UniRule annotation
Metal bindingi40 – 401MagnesiumUniRule annotation
Binding sitei45 – 451SubstrateUniRule annotation
Active sitei88 – 881Proton acceptorUniRule annotation
Binding sitei92 – 921SubstrateUniRule annotation
Binding sitei211 – 2111SubstrateUniRule annotation
Metal bindingi230 – 2301MagnesiumUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-208-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)UniRule annotation (EC:2.5.1.89UniRule annotation)
Alternative name(s):
Undecaprenyl diphosphate synthaseUniRule annotation
Short name:
UDSUniRule annotation
Undecaprenyl pyrophosphate synthaseUniRule annotation
Short name:
UPP synthaseUniRule annotation
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:STK_01890
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)PRO_0000123743Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi273063.ST0189.

Structurei

3D structure databases

ProteinModelPortaliQ976K2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 444Substrate bindingUniRule annotation
Regioni85 – 873Substrate bindingUniRule annotation
Regioni217 – 2193Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01532. Archaea.
COG0020. LUCA.
HOGENOMiHOG000006056.
KOiK15888.
OMAiWAKLKNK.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q976K2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKEKVGKII LYPVYKFYEK ILWNEIKNGP FPQHVGIIPD GNRRWARANN
60 70 80 90 100
LSINDAYYSG YRKLKQVLLW LLEMGIKNIT VFALSTENCD KRSNLELNTI
110 120 130 140 150
FNYIKAGLEE LLYGEIIYKY EVKVRAIGLI YKLPLDLLEV LNQLSKKTEN
160 170 180 190 200
FNKRKLTLAI CYGGRQEIID ATKKIIADYE KGKIKLDDIN ENIFRQYLYD
210 220 230 240 250
KELEDIDLVI RSSGEIRISN FLLWHIAYSE LFFVDTYWPD FRKIDLWRAI
260
RSYQKRKRNF GA
Length:262
Mass (Da):31,135
Last modified:December 1, 2001 - v1
Checksum:iAA45176C79928F85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54181.1.
RefSeqiWP_010978127.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAK54181; BAK54181; STK_01890.
GeneIDi1458073.
KEGGisto:STK_01890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54181.1.
RefSeqiWP_010978127.1. NC_003106.2.

3D structure databases

ProteinModelPortaliQ976K2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273063.ST0189.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAK54181; BAK54181; STK_01890.
GeneIDi1458073.
KEGGisto:STK_01890.

Phylogenomic databases

eggNOGiarCOG01532. Archaea.
COG0020. LUCA.
HOGENOMiHOG000006056.
KOiK15888.
OMAiWAKLKNK.

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-208-MONOMER.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

Entry informationi

Entry nameiUPPS_SULTO
AccessioniPrimary (citable) accession number: Q976K2
Secondary accession number(s): F9VMN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: December 1, 2001
Last modified: December 9, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.