Q976J8 (LYSW_SULTO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha-aminoadipate carrier protein LysW

Alternative name(s):
AAA carrier protein LysW

Gene names

Name:	lysW
Ordered Locus Names:	STK_01925
ORF Names:	STS023

Organism

Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) [Complete proteome] [HAMAP]

Taxonomic identifier

273063 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus › Sulfolobus tokodaii

Protein attributes

Sequence length	56 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Carries the different intermediates in the biosynthesis of L-lysine, from alpha-aminodipate to the final lysine residue By similarity.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway.
Post-translational modification	Binds the amino group of alpha-aminoadipate (AAA) via the gamma-carboxyl group of the C-terminal Glu-56. The link between LysW and alpha-aminodipate (AAA) is catalyzes by LysX By similarity. Binds the amino group of lysine, produced by LysJ, via the gamma-carboxyl group of the C-terminal Glu-56. Unbinding of lysine from LysW is achieved by LysK By similarity.
Sequence similarities	Contains 1 TFIIB-type zinc finger.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Lysine biosynthesis
Domain	Zinc-finger
Ligand	Iron Metal-binding Zinc
PTM	Isopeptide bond
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological_process	lysine biosynthetic process via aminoadipic acid Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 56	56	Alpha-aminoadipate carrier protein LysW		PRO_0000084538
Regions
	Zinc finger	1 – 34	34	TFIIB-type
	Motif	50	1	EDWGE
Sites
	Metal binding	6	1	Iron By similarity
	Metal binding	6	1	Zinc Potential
	Metal binding	9	1	Iron By similarity
	Metal binding	9	1	Zinc Potential
	Metal binding	29	1	Iron By similarity
Amino acid modifications
	Modified residue	56	1	5-glutamyl 2-aminoadipic acid; alternate By similarity
	Modified residue	56	1	5-glutamyl N2-lysine; alternate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q976J8 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: C72792074AD8585A	FASTA	56	6,104
	10 20 30 40 50 MVVLKCPVCN GDVNVPDDAL PGEIVEHECG AQLEVYNDHG RLALRLAEQV GEDWGE

References

[1]

"Complete genome sequence of an aerobic thermoacidophilic Crenarchaeon, Sulfolobus tokodaii strain7." Kawarabayasi Y., Hino Y., Horikawa H., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Otsuka R., Nakazawa H., Takamiya M., Kato Y., Yoshizawa T. , Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Masuda S., Yanagii M., Nishimura M., Yamagishi A., Oshima T., Kikuchi H. DNA Res. 8:123-140(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BA000023 Genomic DNA. Translation: BAB65149.1.

RefSeq

NP_376040.1. NC_003106.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3VPB	X-ray	1.80	E/F	1-56	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

273063.STS023.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

BAB65149; BAB65149; STK_01925.

GeneID

1458077.

KEGG

sto:STS023.

Organism-specific databases

CMR

Search...

Phylogenomic databases

eggNOG

NOG252918.

HOGENOM

HOG000105320.

KO

K05826.

OMA

EIVEHEC.

ProtClustDB

CLSK802585.

Enzyme and pathway databases

UniPathway

UPA00033.

Family and domain databases

PROSITE

PS51134. ZF_TFIIB. False negative.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

LYSW_SULTO

Accession

Primary (citable) accession number: Q976J8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program