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Protein

[LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase

Gene

lysY

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in both the arginine and lysine biosynthetic pathways.UniRule annotation

Catalytic activityi

[LysW]-C-terminal-L-glutamyl-gamma-L-2-aminoadipate 6-phosphate + H+ + NADPH = [LysW]-C-terminal-L-glutamyl-gamma-L-2-aminoadipate 6-semialdehyde + NADP+ + phosphate.UniRule annotation
[LysW]-L-glutamate 5-phosphate + H+ + NADPH = [LysW]-L-glutamate 5-semialdehyde + NADP+ + phosphate.UniRule annotation

Pathwayi: L-lysine biosynthesis via AAA pathway

This protein is involved in step 3 of the subpathway that synthesizes L-lysine from L-alpha-aminoadipate (Thermus route).UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Alpha-aminoadipate--LysW ligase LysX (lysX)
  2. [LysW]-aminoadipate/[LysW]-glutamate kinase (lysZ)
  3. [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase (lysY)
  4. [LysW]-aminoadipate semialdehyde/glutamate semialdehyde transaminase (lysJ)
  5. [LysW]-lysine/[LysW]-ornithine hydrolase (lysK)
This subpathway is part of the pathway L-lysine biosynthesis via AAA pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lysine from L-alpha-aminoadipate (Thermus route), the pathway L-lysine biosynthesis via AAA pathway and in Amino-acid biosynthesis.

Pathwayi: L-arginine biosynthesis

This protein is involved in the pathway L-arginine biosynthesis, which is part of Amino-acid biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei150UniRule annotation1
Binding sitei316NADPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 13NADPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Arginine biosynthesis, Lysine biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00033; UER00037.
UPA00068.

Names & Taxonomyi

Protein namesi
Recommended name:
[LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductaseUniRule annotation (EC:1.2.1.-UniRule annotation)
Gene namesi
Name:lysYUniRule annotation
Synonyms:argC
Ordered Locus Names:STK_01950
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001124991 – 349[LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductaseAdd BLAST349

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi273063.ST0195.

Structurei

3D structure databases

ProteinModelPortaliQ976J5.
SMRiQ976J5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00495. Archaea.
COG0002. LUCA.
HOGENOMiHOG000254904.
KOiK05829.
OMAiTFVPHLT.
OrthoDBiPOG093Z04FU.

Family and domain databases

HAMAPiMF_00150. ArgC_type1. 1 hit.
MF_02083. LysY. 1 hit.
InterProiView protein in InterPro
IPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
PfamiView protein in Pfam
PF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
SMARTiView protein in SMART
SM00859. Semialdhyde_dh. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01850. argC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q976J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRVAVIGGS GYTGGELLRI LAVHPKIEVT YVTSREYAGK PITLVHPNLR
60 70 80 90 100
GFYNMNFSQF SFDKLGDKAD AVFLGLPHKV SLEYVPKILE MGIQVIDLSA
110 120 130 140 150
DFRLKDPTLY KIWYGYEHPY PDLLKKAVYG LPELHYEELK NAKLIASPGC
160 170 180 190 200
NATATILAGA PLVASSLLET YKLISDVKVG SSEGGAKPHE GSHHPERQNA
210 220 230 240 250
IRPYEADGHR HAAEAEQELS LIAKRDVKVS LVPHAVSSVR GALASVHGWL
260 270 280 290 300
SSDISEMDMW KKSIEFYKGR KFIRIIRSNI HPYPDPKFVI GSNFADIGFA
310 320 330 340
IEKRMQRITM FSAIDNLMKG AAGQAVQAFN ISRGFEEDEG LRIPPLRPA
Length:349
Mass (Da):38,700
Last modified:October 19, 2002 - v2
Checksum:iEFF1EE06BBA5847B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54184.1.
RefSeqiWP_010978134.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAK54184; BAK54184; STK_01950.
GeneIDi1458080.
KEGGisto:STK_01950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54184.1.
RefSeqiWP_010978134.1. NC_003106.2.

3D structure databases

ProteinModelPortaliQ976J5.
SMRiQ976J5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273063.ST0195.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAK54184; BAK54184; STK_01950.
GeneIDi1458080.
KEGGisto:STK_01950.

Phylogenomic databases

eggNOGiarCOG00495. Archaea.
COG0002. LUCA.
HOGENOMiHOG000254904.
KOiK05829.
OMAiTFVPHLT.
OrthoDBiPOG093Z04FU.

Enzyme and pathway databases

UniPathwayiUPA00033; UER00037.
UPA00068.

Family and domain databases

HAMAPiMF_00150. ArgC_type1. 1 hit.
MF_02083. LysY. 1 hit.
InterProiView protein in InterPro
IPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
PfamiView protein in Pfam
PF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
SMARTiView protein in SMART
SM00859. Semialdhyde_dh. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01850. argC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLYSY_SULTO
AccessioniPrimary (citable) accession number: Q976J5
Secondary accession number(s): F9VMN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: May 10, 2017
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.