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Q976G4

- DNLI_SULTO

UniProt

Q976G4 - DNLI_SULTO

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Protein

DNA ligase

Gene

lig

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.By similarity

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

Cofactori

Divalent metal cations.By similarity

Enzyme regulationi

Inhibited by PCNA123 and PCNA323.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei258 – 2581ATPBy similarity
Active sitei260 – 2601N6-AMP-lysine intermediateBy similarity
Binding sitei265 – 2651ATPBy similarity
Binding sitei280 – 2801ATPBy similarity
Binding sitei310 – 3101ATPBy similarity
Binding sitei350 – 3501ATPBy similarity
Binding sitei427 – 4271ATPBy similarity
Binding sitei433 – 4331ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-248-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:STK_02230
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001015: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600DNA ligasePRO_0000059619Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273063.ST0223.

Structurei

3D structure databases

ProteinModelPortaliQ976G4.
SMRiQ976G4. Positions 1-590.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.Curated

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiLDPSGYN.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q976G4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFKLIAEYF DKLEKISSRL QLTALLTDLF KKADKNVIDK VVYLIQGKLW
60 70 80 90 100
PDFLGYPELG VGEKLLIKAI SIAVNVKEEV VEEQLKVVGD LGEVAMRLKK
110 120 130 140 150
TPQSASILSF LGAQSNEGLT VEETYESLTK IALASGEGSR DIKIRSLAGL
160 170 180 190 200
LKKASPLEAK YIVRFVDGRL RVGIGDATIM DALSTAFTGS TSFRPLIERA
210 220 230 240 250
YNLRADLGNI AKIIAQQGVE ALKDIKPQVG IPIRPMLAER MSDPAEILAK
260 270 280 290 300
VGGEALVDYK YDGERAQIHK KDKEVYIFSR RLENITRMYP DVVEYVREYI
310 320 330 340 350
NANEVIIEGE IVAVDPESNE IRPFQELMHR KRKNDINEAI KEYPVNVYLF
360 370 380 390 400
DLMLYEDADY TMKPLPERRK KLEEVIKPND KLHIAHHIYT NNVDKLMEFF
410 420 430 440 450
YDAISNGAEG VMVKSVAKDS IYQAGSRGFL WIKLKRDYQS EMADSVDLVV
460 470 480 490 500
VGAFYGRGKR GGKLSSLLMA AYDPETDTFK TVCKVASGFS DAELDELQKK
510 520 530 540 550
LMEIKLDKKD PRVDSQLEPD IWVEPKYVAE IIGAEITLSP EHTCCKDMVS
560 570 580 590 600
KGAGLSVRFP RFIRWRDDKS IEDATTPKEI YEMYKMKLRK KEEEQHTDEA
Length:600
Mass (Da):68,025
Last modified:December 1, 2001 - v1
Checksum:i9D85DA4458000539
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000023 Genomic DNA. Translation: BAB65183.1.
RefSeqiNP_376074.1. NC_003106.2.
WP_010978165.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAB65183; BAB65183; STK_02230.
GeneIDi1458113.
KEGGisto:ST0223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000023 Genomic DNA. Translation: BAB65183.1 .
RefSeqi NP_376074.1. NC_003106.2.
WP_010978165.1. NC_003106.2.

3D structure databases

ProteinModelPortali Q976G4.
SMRi Q976G4. Positions 1-590.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273063.ST0223.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB65183 ; BAB65183 ; STK_02230 .
GeneIDi 1458113.
KEGGi sto:ST0223.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi LDPSGYN.

Enzyme and pathway databases

BioCyci STOK273063:GJC7-248-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.
  2. "Spatial subunit distribution and in vitro functions of the novel trimeric PCNA complex from Sulfolobus tokodaii."
    Lu S., Li Z., Wang Z., Ma X., Sheng D., Ni J., Shen Y.
    Biochem. Biophys. Res. Commun. 376:369-374(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION.
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

Entry informationi

Entry nameiDNLI_SULTO
AccessioniPrimary (citable) accession number: Q976G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3