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Q976G4 (DNLI_SULTO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:STK_02230
OrganismSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) [Complete proteome] [HAMAP]
Taxonomic identifier273063 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length600 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 600600DNA ligase HAMAP-Rule MF_00407
PRO_0000059619

Sites

Active site2601N6-AMP-lysine intermediate By similarity
Binding site2581ATP By similarity
Binding site2651ATP By similarity
Binding site2801ATP By similarity
Binding site3101ATP By similarity
Binding site3501ATP By similarity
Binding site4271ATP By similarity
Binding site4331ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q976G4 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 9D85DA4458000539

FASTA60068,025
        10         20         30         40         50         60 
MEFKLIAEYF DKLEKISSRL QLTALLTDLF KKADKNVIDK VVYLIQGKLW PDFLGYPELG 

        70         80         90        100        110        120 
VGEKLLIKAI SIAVNVKEEV VEEQLKVVGD LGEVAMRLKK TPQSASILSF LGAQSNEGLT 

       130        140        150        160        170        180 
VEETYESLTK IALASGEGSR DIKIRSLAGL LKKASPLEAK YIVRFVDGRL RVGIGDATIM 

       190        200        210        220        230        240 
DALSTAFTGS TSFRPLIERA YNLRADLGNI AKIIAQQGVE ALKDIKPQVG IPIRPMLAER 

       250        260        270        280        290        300 
MSDPAEILAK VGGEALVDYK YDGERAQIHK KDKEVYIFSR RLENITRMYP DVVEYVREYI 

       310        320        330        340        350        360 
NANEVIIEGE IVAVDPESNE IRPFQELMHR KRKNDINEAI KEYPVNVYLF DLMLYEDADY 

       370        380        390        400        410        420 
TMKPLPERRK KLEEVIKPND KLHIAHHIYT NNVDKLMEFF YDAISNGAEG VMVKSVAKDS 

       430        440        450        460        470        480 
IYQAGSRGFL WIKLKRDYQS EMADSVDLVV VGAFYGRGKR GGKLSSLLMA AYDPETDTFK 

       490        500        510        520        530        540 
TVCKVASGFS DAELDELQKK LMEIKLDKKD PRVDSQLEPD IWVEPKYVAE IIGAEITLSP 

       550        560        570        580        590        600 
EHTCCKDMVS KGAGLSVRFP RFIRWRDDKS IEDATTPKEI YEMYKMKLRK KEEEQHTDEA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000023 Genomic DNA. Translation: BAB65183.1.
RefSeqNP_376074.1. NC_003106.2.

3D structure databases

ProteinModelPortalQ976G4.
SMRQ976G4. Positions 1-590.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273063.ST0223.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB65183; BAB65183; STK_02230.
GeneID1458113.
KEGGsto:ST0223.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK10747.
OMAYIARFVV.
ProtClustDBPRK01109.

Enzyme and pathway databases

BioCycSTOK273063:GJC7-248-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_SULTO
AccessionPrimary (citable) accession number: Q976G4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families