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Q976G4

- DNLI_SULTO

UniProt

Q976G4 - DNLI_SULTO

Protein

DNA ligase

Gene

lig

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.By similarity

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

    Cofactori

    Divalent metal cations.By similarity

    Enzyme regulationi

    Inhibited by PCNA123 and PCNA323.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei258 – 2581ATPBy similarity
    Active sitei260 – 2601N6-AMP-lysine intermediateBy similarity
    Binding sitei265 – 2651ATPBy similarity
    Binding sitei280 – 2801ATPBy similarity
    Binding sitei310 – 3101ATPBy similarity
    Binding sitei350 – 3501ATPBy similarity
    Binding sitei427 – 4271ATPBy similarity
    Binding sitei433 – 4331ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSTOK273063:GJC7-248-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligase (EC:6.5.1.1)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]
    Gene namesi
    Name:lig
    Ordered Locus Names:STK_02230
    OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
    Taxonomic identifieri273063 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001015: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 600600DNA ligasePRO_0000059619Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273063.ST0223.

    Structurei

    3D structure databases

    ProteinModelPortaliQ976G4.
    SMRiQ976G4. Positions 1-590.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.Curated

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiLDPSGYN.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q976G4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFKLIAEYF DKLEKISSRL QLTALLTDLF KKADKNVIDK VVYLIQGKLW    50
    PDFLGYPELG VGEKLLIKAI SIAVNVKEEV VEEQLKVVGD LGEVAMRLKK 100
    TPQSASILSF LGAQSNEGLT VEETYESLTK IALASGEGSR DIKIRSLAGL 150
    LKKASPLEAK YIVRFVDGRL RVGIGDATIM DALSTAFTGS TSFRPLIERA 200
    YNLRADLGNI AKIIAQQGVE ALKDIKPQVG IPIRPMLAER MSDPAEILAK 250
    VGGEALVDYK YDGERAQIHK KDKEVYIFSR RLENITRMYP DVVEYVREYI 300
    NANEVIIEGE IVAVDPESNE IRPFQELMHR KRKNDINEAI KEYPVNVYLF 350
    DLMLYEDADY TMKPLPERRK KLEEVIKPND KLHIAHHIYT NNVDKLMEFF 400
    YDAISNGAEG VMVKSVAKDS IYQAGSRGFL WIKLKRDYQS EMADSVDLVV 450
    VGAFYGRGKR GGKLSSLLMA AYDPETDTFK TVCKVASGFS DAELDELQKK 500
    LMEIKLDKKD PRVDSQLEPD IWVEPKYVAE IIGAEITLSP EHTCCKDMVS 550
    KGAGLSVRFP RFIRWRDDKS IEDATTPKEI YEMYKMKLRK KEEEQHTDEA 600
    Length:600
    Mass (Da):68,025
    Last modified:December 1, 2001 - v1
    Checksum:i9D85DA4458000539
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000023 Genomic DNA. Translation: BAB65183.1.
    RefSeqiNP_376074.1. NC_003106.2.
    WP_010978165.1. NC_003106.2.

    Genome annotation databases

    EnsemblBacteriaiBAB65183; BAB65183; STK_02230.
    GeneIDi1458113.
    KEGGisto:ST0223.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000023 Genomic DNA. Translation: BAB65183.1 .
    RefSeqi NP_376074.1. NC_003106.2.
    WP_010978165.1. NC_003106.2.

    3D structure databases

    ProteinModelPortali Q976G4.
    SMRi Q976G4. Positions 1-590.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273063.ST0223.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB65183 ; BAB65183 ; STK_02230 .
    GeneIDi 1458113.
    KEGGi sto:ST0223.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi LDPSGYN.

    Enzyme and pathway databases

    BioCyci STOK273063:GJC7-248-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.
    2. "Spatial subunit distribution and in vitro functions of the novel trimeric PCNA complex from Sulfolobus tokodaii."
      Lu S., Li Z., Wang Z., Ma X., Sheng D., Ni J., Shen Y.
      Biochem. Biophys. Res. Commun. 376:369-374(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION.
      Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

    Entry informationi

    Entry nameiDNLI_SULTO
    AccessioniPrimary (citable) accession number: Q976G4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3