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Protein

DNA ligase

Gene

lig

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Inhibited by PCNA123 and PCNA323.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei258ATPUniRule annotation1
Active sitei260N6-AMP-lysine intermediateUniRule annotation1
Binding sitei265ATPUniRule annotation1
Binding sitei280ATPUniRule annotation1
Binding sitei310ATPUniRule annotation1
Binding sitei350ATPUniRule annotation1
Binding sitei427ATPUniRule annotation1
Binding sitei433ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTOK273063:G1G3D-262-MONOMER
BRENDAi6.5.1.1 6166

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:STK_02230
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000596191 – 600DNA ligaseAdd BLAST600

Interactioni

Protein-protein interaction databases

STRINGi273063.ST0223

Structurei

3D structure databases

ProteinModelPortaliQ976G4
SMRiQ976G4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWIKYKRD
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

Q976G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFKLIAEYF DKLEKISSRL QLTALLTDLF KKADKNVIDK VVYLIQGKLW
60 70 80 90 100
PDFLGYPELG VGEKLLIKAI SIAVNVKEEV VEEQLKVVGD LGEVAMRLKK
110 120 130 140 150
TPQSASILSF LGAQSNEGLT VEETYESLTK IALASGEGSR DIKIRSLAGL
160 170 180 190 200
LKKASPLEAK YIVRFVDGRL RVGIGDATIM DALSTAFTGS TSFRPLIERA
210 220 230 240 250
YNLRADLGNI AKIIAQQGVE ALKDIKPQVG IPIRPMLAER MSDPAEILAK
260 270 280 290 300
VGGEALVDYK YDGERAQIHK KDKEVYIFSR RLENITRMYP DVVEYVREYI
310 320 330 340 350
NANEVIIEGE IVAVDPESNE IRPFQELMHR KRKNDINEAI KEYPVNVYLF
360 370 380 390 400
DLMLYEDADY TMKPLPERRK KLEEVIKPND KLHIAHHIYT NNVDKLMEFF
410 420 430 440 450
YDAISNGAEG VMVKSVAKDS IYQAGSRGFL WIKLKRDYQS EMADSVDLVV
460 470 480 490 500
VGAFYGRGKR GGKLSSLLMA AYDPETDTFK TVCKVASGFS DAELDELQKK
510 520 530 540 550
LMEIKLDKKD PRVDSQLEPD IWVEPKYVAE IIGAEITLSP EHTCCKDMVS
560 570 580 590 600
KGAGLSVRFP RFIRWRDDKS IEDATTPKEI YEMYKMKLRK KEEEQHTDEA
Length:600
Mass (Da):68,025
Last modified:December 1, 2001 - v1
Checksum:i9D85DA4458000539
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA Translation: BAB65183.1
RefSeqiWP_010978165.1, NC_003106.2

Genome annotation databases

EnsemblBacteriaiBAB65183; BAB65183; STK_02230
GeneIDi1458113
KEGGisto:STK_02230
PATRICifig|273063.9.peg.271

Similar proteinsi

Entry informationi

Entry nameiDNLI_SULTO
AccessioniPrimary (citable) accession number: Q976G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health