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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53SubstrateUniRule annotation1
Binding sitei124SubstrateUniRule annotation1
Binding sitei147SubstrateUniRule annotation1
Binding sitei177SubstrateUniRule annotation1
Binding sitei181SubstrateUniRule annotation1
Binding sitei182NADUniRule annotation1
Binding sitei234NADUniRule annotation1
Binding sitei269NADUniRule annotation1
Binding sitei337NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi148 – 150NADUniRule annotation3
Nucleotide bindingi211 – 216NADUniRule annotation6
Nucleotide bindingi290 – 292NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:STK_03420
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

Subcellular locationi

Q975T0:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001170161 – 415AdenosylhomocysteinaseAdd BLAST415

Interactioni

Protein-protein interaction databases

STRINGi273063.ST0342.

Structurei

3D structure databases

ProteinModelPortaliQ975T0.
SMRiQ975T0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04137. Archaea.
COG0499. LUCA.
HOGENOMiHOG000227987.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG093Z03XF.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 2 hits.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q975T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYKVKDLSL AEQGKKQIEW AEIHMPALME IRKQFEKEKP LQGLRISAVL
60 70 80 90 100
HVTKETAVLV KTLKIGGATV ALAGSNPLST QDDVAAALVE EGIRVFAWRG
110 120 130 140 150
ETEKDYYDNI KEILKYEPQI IMDDGGDLHA YVHENMPQLK LFGGTEETTT
160 170 180 190 200
GVIRLKAMEE QGVLRYPVIA VNNAFTKYLF DNRIGTGQST IDGILRATNI
210 220 230 240 250
LIAGKVAVVA GYGWVGRGIA QRLRGMGARV IVVEVSPLRA LEAVMDGFDV
260 270 280 290 300
MPMSKAAELG EIFITATGNI NVIRKEHILK MKDGAILANS GHFNVEIDVK
310 320 330 340 350
GLKEMAKSSR LIRPNLEEYE LPNGKRIYLL AEGRLVNLAA AEGHPSEVMD
360 370 380 390 400
LSFSNQALSV KYIYENRGKL ENKVYNVPQE IDETVAKLKL NGMGIEIEPM
410
TQEQIEYMKQ WRYGT
Length:415
Mass (Da):46,207
Last modified:December 1, 2001 - v1
Checksum:iEDF3DF7F36B9BA5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54243.1.
RefSeqiWP_010978302.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAK54243; BAK54243; STK_03420.
GeneIDi1458257.
KEGGisto:STK_03420.
PATRICifig|273063.9.peg.399.

Similar proteinsi

Entry informationi

Entry nameiSAHH_SULTO
AccessioniPrimary (citable) accession number: Q975T0
Secondary accession number(s): F9VMU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: December 1, 2001
Last modified: October 25, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families