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Protein

DNA polymerase sliding clamp 1

Gene

pcn1

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). The trimeric complex inhibits DNA ligase and both 3'-5' and 5'-3' activity of Hel308 (Hjm) helicase, but stimulates Hjc, the Holliday junction cleavage enzyme.UniRule annotation1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-447-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase sliding clamp 1UniRule annotation
Alternative name(s):
Proliferating cell nuclear antigen homolog 1UniRule annotation
Short name:
PCNA1UniRule annotation
Gene namesi
Name:pcn1UniRule annotation
Synonyms:pcnA
Ordered Locus Names:STK_03870
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245DNA polymerase sliding clamp 1PRO_0000149217Add
BLAST

Interactioni

Subunit structurei

The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA (By similarity). Forms a dimeric complex with PCNA3 and a trimeric complex with PCNA2 and PCNA3; does not form homotrimers (PubMed:18782564).By similarity1 Publication

Protein-protein interaction databases

STRINGi273063.ST0387.

Structurei

Secondary structure

1
245
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 65Combined sources
Helixi8 – 2114Combined sources
Beta strandi23 – 308Combined sources
Beta strandi33 – 397Combined sources
Beta strandi43 – 5210Combined sources
Helixi53 – 553Combined sources
Beta strandi56 – 605Combined sources
Beta strandi65 – 706Combined sources
Helixi71 – 788Combined sources
Beta strandi87 – 937Combined sources
Beta strandi96 – 1016Combined sources
Beta strandi103 – 1053Combined sources
Beta strandi107 – 1126Combined sources
Beta strandi129 – 1357Combined sources
Helixi136 – 14914Combined sources
Beta strandi151 – 1577Combined sources
Beta strandi159 – 17012Combined sources
Beta strandi174 – 1774Combined sources
Helixi178 – 1803Combined sources
Beta strandi183 – 1908Combined sources
Beta strandi192 – 1976Combined sources
Helixi198 – 2036Combined sources
Helixi204 – 2107Combined sources
Beta strandi212 – 2187Combined sources
Beta strandi224 – 2296Combined sources
Helixi231 – 2333Combined sources
Beta strandi235 – 2406Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UD9X-ray1.68A/B/C/D2-245[»]
ProteinModelPortaliQ975N2.
SMRiQ975N2. Positions 2-245.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ975N2.

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00488. Archaea.
COG0592. LUCA.
HOGENOMiHOG000222371.
KOiK04802.
OMAiLEFNMEG.

Family and domain databases

HAMAPiMF_00317. DNApol_clamp_arch. 1 hit.
InterProiIPR000730. Pr_cel_nuc_antig.
IPR022649. Pr_cel_nuc_antig_C.
IPR022659. Pr_cel_nuc_antig_CS.
IPR022648. Pr_cel_nuc_antig_N.
[Graphical view]
PANTHERiPTHR11352. PTHR11352. 1 hit.
PfamiPF02747. PCNA_C. 1 hit.
PF00705. PCNA_N. 1 hit.
[Graphical view]
PRINTSiPR00339. PCNACYCLIN.
TIGRFAMsiTIGR00590. pcna. 1 hit.
PROSITEiPS01251. PCNA_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q975N2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHIVYDDVRD LKAIIQALLK LVDEALFDIK PEGIQLVAID KAHISLIKIE
60 70 80 90 100
LPKEMFKEYD VPEEFKFGFN TQYMSKLLKA AKRKEEIIID ADSPEVVKLT
110 120 130 140 150
LSGALNRVFN VNNIEVLPPE VPEVNLEFDI KATINASGLK NAIGEIAEVA
160 170 180 190 200
DTLLISGNEE KVVVKGEGEN KVEVEFSKDT GSLADIEFNK ESSSAYDVEY
210 220 230 240
LNDIISLTKL SDYVKVAFAD QKPMQLEFNM EGGGKVTYLL APKLS
Length:245
Mass (Da):27,284
Last modified:December 1, 2001 - v1
Checksum:iBB73C45F8A83D91A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54261.1.
RefSeqiWP_010978351.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAK54261; BAK54261; STK_03870.
GeneIDi1458312.
KEGGisto:STK_03870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54261.1.
RefSeqiWP_010978351.1. NC_003106.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UD9X-ray1.68A/B/C/D2-245[»]
ProteinModelPortaliQ975N2.
SMRiQ975N2. Positions 2-245.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273063.ST0387.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAK54261; BAK54261; STK_03870.
GeneIDi1458312.
KEGGisto:STK_03870.

Phylogenomic databases

eggNOGiarCOG00488. Archaea.
COG0592. LUCA.
HOGENOMiHOG000222371.
KOiK04802.
OMAiLEFNMEG.

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-447-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ975N2.

Family and domain databases

HAMAPiMF_00317. DNApol_clamp_arch. 1 hit.
InterProiIPR000730. Pr_cel_nuc_antig.
IPR022649. Pr_cel_nuc_antig_C.
IPR022659. Pr_cel_nuc_antig_CS.
IPR022648. Pr_cel_nuc_antig_N.
[Graphical view]
PANTHERiPTHR11352. PTHR11352. 1 hit.
PfamiPF02747. PCNA_C. 1 hit.
PF00705. PCNA_N. 1 hit.
[Graphical view]
PRINTSiPR00339. PCNACYCLIN.
TIGRFAMsiTIGR00590. pcna. 1 hit.
PROSITEiPS01251. PCNA_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCNA1_SULTO
AccessioniPrimary (citable) accession number: Q975N2
Secondary accession number(s): F9VMW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.