psmA

Functionⁱ

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityⁱ

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationⁱ

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

Enzyme and pathway databases

BioCycⁱ	STOK273063:GJC7-519-MONOMER.

BioCycⁱ

STOK273063:GJC7-519-MONOMER.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Proteasome subunit alphaUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00289 (EC:3.4.25.1UniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00289 ) Alternative name(s): 20S proteasome alpha subunitUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00289 Proteasome core protein PsmAUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00289
Gene namesⁱ	Name:psmAUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00289 Ordered Locus Names:STK_04460
Organismⁱ	Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifierⁱ	273063 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Archaea › TACK group › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus › Sulfolobus tokodaii
Proteomesⁱ	UP000001015 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00289

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell
proteasome core complex, alpha-subunit complex Source: UniProtKB-HAMAP

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm, Proteasome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 242	242	Proteasome subunit alpha		PRO_0000124188	Add BLAST

Interactionⁱ

Subunit structureⁱ

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	273063.ST0446.

STRINGⁱ

273063.ST0446.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q975G5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the peptidase T1A family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	arCOG00971. Archaea. COG0638. LUCA.
HOGENOMⁱ	HOG000091085.
KOⁱ	K03432.

Family and domain databases

Gene3Dⁱ	3.60.20.10. 1 hit.
HAMAPⁱ	MF_00289_A. Proteasome_A_A. 1 hit.
InterProⁱ	IPR029055. Ntn_hydrolases_N. IPR019982. Proteasome_asu_arc. IPR000426. Proteasome_asu_N. IPR023332. Proteasome_suA-type. IPR001353. Proteasome_sua/b. [Graphical view]
Pfamⁱ	PF00227. Proteasome. 1 hit. PF10584. Proteasome_A_N. 1 hit. [Graphical view]
SMARTⁱ	SM00948. Proteasome_A_N. 1 hit. [Graphical view]
SUPFAMⁱ	SSF56235. SSF56235. 1 hit.
TIGRFAMsⁱ	TIGR03633. arc_protsome_A. 1 hit.
PROSITEⁱ	PS00388. PROTEASOME_ALPHA_1. 1 hit. PS51475. PROTEASOME_ALPHA_2. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

Q975G5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAFGPAAMGY DRAITIFSPD GSLYQVDYAF EAVKKGWTTL GVKTKAGVVL 
        60         70         80         90        100
IGEKRKATQL LDVDSIEKVF ILDDHVGCSF AGLASDGRIL IDYARSQALQ 
       110        120        130        140        150
HRLIYDEPIN IDYLTKLVSD VKQMYTQHGG VRPFGVALII GGIDRGKTPK 
       160        170        180        190        200
LLMTEPSGQF MPYYAVAIGQ GGYTATEYFE KNYREDLNMQ DTILLGIRAL 
       210        220        230        240 
ASTLKPGEKL APSNIEVGFA DVDSGMFRKM SFEERASILQ KL

Length:242

Mass (Da):26,667

Last modified:June 6, 2002 - v2

Checksum:ⁱ7CAD8AAD4CCF8C19

GO

Sequence cautionⁱ

The sequence BAB65436 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BA000023 Genomic DNA. Translation: BAB65436.1. Different initiation.
RefSeqⁱ	WP_052846326.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaⁱ	BAB65436; BAB65436; STK_04460.
GeneIDⁱ	1458383.
KEGGⁱ	sto:STK_04460.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BA000023 Genomic DNA. Translation: BAB65436.1. Different initiation.
RefSeqⁱ	WP_052846326.1. NC_003106.2.

3D structure databases

ProteinModelPortalⁱ	Q975G5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	273063.ST0446.

STRINGⁱ

273063.ST0446.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	BAB65436; BAB65436; STK_04460.
GeneIDⁱ	1458383.
KEGGⁱ	sto:STK_04460.

Phylogenomic databases

eggNOGⁱ	arCOG00971. Archaea. COG0638. LUCA.
HOGENOMⁱ	HOG000091085.
KOⁱ	K03432.

Enzyme and pathway databases

BioCycⁱ	STOK273063:GJC7-519-MONOMER.

BioCycⁱ

STOK273063:GJC7-519-MONOMER.

Family and domain databases

Gene3Dⁱ	3.60.20.10. 1 hit.
HAMAPⁱ	MF_00289_A. Proteasome_A_A. 1 hit.
InterProⁱ	IPR029055. Ntn_hydrolases_N. IPR019982. Proteasome_asu_arc. IPR000426. Proteasome_asu_N. IPR023332. Proteasome_suA-type. IPR001353. Proteasome_sua/b. [Graphical view]
Pfamⁱ	PF00227. Proteasome. 1 hit. PF10584. Proteasome_A_N. 1 hit. [Graphical view]
SMARTⁱ	SM00948. Proteasome_A_N. 1 hit. [Graphical view]
SUPFAMⁱ	SSF56235. SSF56235. 1 hit.
TIGRFAMsⁱ	TIGR03633. arc_protsome_A. 1 hit.
PROSITEⁱ	PS00388. PROTEASOME_ALPHA_1. 1 hit. PS51475. PROTEASOME_ALPHA_2. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

PSA_SULTO

Accessionⁱ

Primary (citable) accession number: Q975G5

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	June 6, 2002
Last sequence update:	June 6, 2002
Last modified:	December 9, 2015
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Peptidase families
Classification of peptidase families and list of entries
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q975G5 (PSA_SULTO)

UniProt

Q975G5 - PSA_SULTO

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Proteasome subunit alpha

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>Describes an enzyme regulatory mechanism and reports the components which regulate (by activation or inhibition) the reaction.</p><p><a href='../manual/enzyme_regulation' target='_top'>More...</a></p>Enzyme regulationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

<p>Reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.</p><p><a href='../manual/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Enzyme regulationⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ