psmA

Functionⁱ

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityⁱ

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationⁱ

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

GO - Molecular functionⁱ

threonine-type endopeptidase activity Source: UniProtKB-KW

Complete GO annotation...

GO - Biological processⁱ

ubiquitin-dependent protein catabolic process Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Threonine protease

Molecular function

Hydrolase, Protease, Threonine protease

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Proteasome subunit alphaUniRule annotation (EC:3.4.25.1UniRule annotation) Alternative name(s): 20S proteasome alpha subunitUniRule annotation Proteasome core protein PsmAUniRule annotation
Gene namesⁱ	Name:psmAUniRule annotation Ordered Locus Names:STK_04460
Organismⁱ	Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifierⁱ	273063 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Archaea › TACK group › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus › Sulfolobus tokodaii
Proteomesⁱ	UP000001015 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00289

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell
proteasome core complex, alpha-subunit complex Source: InterPro

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm, Proteasome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000124188	1 – 242	Proteasome subunit alphaAdd BLAST		242

Interactionⁱ

Subunit structureⁱ

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	273063.ST0446.

STRINGⁱ

273063.ST0446.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q975G5.
SMRⁱ	Q975G5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the peptidase T1A family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	arCOG00971. Archaea. COG0638. LUCA.
HOGENOMⁱ	HOG000091085.
KEGG Orthology (KO) More...KOⁱ	K03432.
Database of Orthologous Groups More...OrthoDBⁱ	POG093Z086S.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03756. proteasome_alpha_archeal. 1 hit.
Gene3Dⁱ	3.60.20.10. 1 hit.
HAMAPⁱ	MF_00289_A. Proteasome_A_A. 1 hit.
InterProⁱ	View protein in InterPro IPR029055. Ntn_hydrolases_N. IPR023332. Proteasome_alpha-type. IPR019982. Proteasome_asu_arc. IPR000426. Proteasome_asu_N. IPR001353. Proteasome_sua/b.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00227. Proteasome. 1 hit. PF10584. Proteasome_A_N. 1 hit.
SMARTⁱ	View protein in SMART SM00948. Proteasome_A_N. 1 hit.
SUPFAMⁱ	SSF56235. SSF56235. 1 hit.
TIGRFAMsⁱ	TIGR03633. arc_protsome_A. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00388. PROTEASOME_ALPHA_1. 1 hit. PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q975G5-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAFGPAAMGY DRAITIFSPD GSLYQVDYAF EAVKKGWTTL GVKTKAGVVL 
        60         70         80         90        100
IGEKRKATQL LDVDSIEKVF ILDDHVGCSF AGLASDGRIL IDYARSQALQ 
       110        120        130        140        150
HRLIYDEPIN IDYLTKLVSD VKQMYTQHGG VRPFGVALII GGIDRGKTPK 
       160        170        180        190        200
LLMTEPSGQF MPYYAVAIGQ GGYTATEYFE KNYREDLNMQ DTILLGIRAL 
       210        220        230        240 
ASTLKPGEKL APSNIEVGFA DVDSGMFRKM SFEERASILQ KL

Length:242

Mass (Da):26,667

Last modified:June 6, 2002 - v2

Checksum:ⁱ7CAD8AAD4CCF8C19

GO

Sequence cautionⁱ

The sequence BAB65436 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BA000023 Genomic DNA. Translation: BAB65436.1. Different initiation.
NCBI Reference Sequences More...RefSeqⁱ	WP_052846326.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaⁱ	BAB65436; BAB65436; STK_04460.
GeneIDⁱ	1458383.
KEGGⁱ	sto:STK_04460.
PATRICⁱ	fig\|273063.9.peg.518.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BA000023 Genomic DNA. Translation: BAB65436.1. Different initiation.
NCBI Reference Sequences More...RefSeqⁱ	WP_052846326.1. NC_003106.2.

3D structure databases

ProteinModelPortalⁱ	Q975G5.
SMRⁱ	Q975G5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	273063.ST0446.

STRINGⁱ

273063.ST0446.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	BAB65436; BAB65436; STK_04460.
GeneIDⁱ	1458383.
KEGGⁱ	sto:STK_04460.
PATRICⁱ	fig\|273063.9.peg.518.

Phylogenomic databases

eggNOGⁱ	arCOG00971. Archaea. COG0638. LUCA.
HOGENOMⁱ	HOG000091085.
KEGG Orthology (KO) More...KOⁱ	K03432.
Database of Orthologous Groups More...OrthoDBⁱ	POG093Z086S.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03756. proteasome_alpha_archeal. 1 hit.
Gene3Dⁱ	3.60.20.10. 1 hit.
HAMAPⁱ	MF_00289_A. Proteasome_A_A. 1 hit.
InterProⁱ	View protein in InterPro IPR029055. Ntn_hydrolases_N. IPR023332. Proteasome_alpha-type. IPR019982. Proteasome_asu_arc. IPR000426. Proteasome_asu_N. IPR001353. Proteasome_sua/b.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00227. Proteasome. 1 hit. PF10584. Proteasome_A_N. 1 hit.
SMARTⁱ	View protein in SMART SM00948. Proteasome_A_N. 1 hit.
SUPFAMⁱ	SSF56235. SSF56235. 1 hit.
TIGRFAMsⁱ	TIGR03633. arc_protsome_A. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00388. PROTEASOME_ALPHA_1. 1 hit. PS51475. PROTEASOME_ALPHA_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PSA_SULTO
Accessionⁱ	Q975G5Primary (citable) accession number: Q975G5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 6, 2002
	Last sequence update:	June 6, 2002
	Last modified:	June 7, 2017
	This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q975G5 (PSA_SULTO)

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Proteasome subunit alpha

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes an enzyme regulatory mechanism and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/enzyme_regulation' target='_top'>More...</a></p>Enzyme regulationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Enzyme regulationⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ