UniProtKB - Q975G5 (PSA_SULTO)
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Protein
Proteasome subunit alpha
Gene
psmA
Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Functioni
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation
Catalytic activityi
Cleavage of peptide bonds with very broad specificity.UniRule annotation
Enzyme regulationi
The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation
GO - Molecular functioni
- threonine-type endopeptidase activity Source: UniProtKB-KW
GO - Biological processi
- ubiquitin-dependent protein catabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Threonine protease |
Enzyme and pathway databases
BioCyci | STOK273063:G1G3D-532-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: Proteasome subunit alphaUniRule annotation (EC:3.4.25.1UniRule annotation)Alternative name(s): 20S proteasome alpha subunitUniRule annotation Proteasome core protein PsmAUniRule annotation |
Gene namesi | Name:psmAUniRule annotation Ordered Locus Names:STK_04460 |
Organismi | Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) |
Taxonomic identifieri | 273063 [NCBI] |
Taxonomic lineagei | Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
- proteasome core complex, alpha-subunit complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, ProteasomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000124188 | 1 – 242 | Proteasome subunit alphaAdd BLAST | 242 |
Interactioni
Subunit structurei
The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotation
Protein-protein interaction databases
STRINGi | 273063.ST0446. |
Structurei
3D structure databases
ProteinModelPortali | Q975G5. |
SMRi | Q975G5. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase T1A family.UniRule annotation
Phylogenomic databases
eggNOGi | arCOG00971. Archaea. COG0638. LUCA. |
HOGENOMi | HOG000091085. |
KOi | K03432. |
OrthoDBi | POG093Z086S. |
Family and domain databases
CDDi | cd03756. proteasome_alpha_archeal. 1 hit. |
Gene3Di | 3.60.20.10. 1 hit. |
HAMAPi | MF_00289_A. Proteasome_A_A. 1 hit. |
InterProi | View protein in InterPro IPR029055. Ntn_hydrolases_N. IPR023332. Proteasome_alpha-type. IPR019982. Proteasome_asu_arc. IPR000426. Proteasome_asu_N. IPR001353. Proteasome_sua/b. |
Pfami | View protein in Pfam PF00227. Proteasome. 1 hit. PF10584. Proteasome_A_N. 1 hit. |
SMARTi | View protein in SMART SM00948. Proteasome_A_N. 1 hit. |
SUPFAMi | SSF56235. SSF56235. 1 hit. |
TIGRFAMsi | TIGR03633. arc_protsome_A. 1 hit. |
PROSITEi | View protein in PROSITE PS00388. PROTEASOME_ALPHA_1. 1 hit. PS51475. PROTEASOME_ALPHA_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q975G5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAFGPAAMGY DRAITIFSPD GSLYQVDYAF EAVKKGWTTL GVKTKAGVVL
60 70 80 90 100
IGEKRKATQL LDVDSIEKVF ILDDHVGCSF AGLASDGRIL IDYARSQALQ
110 120 130 140 150
HRLIYDEPIN IDYLTKLVSD VKQMYTQHGG VRPFGVALII GGIDRGKTPK
160 170 180 190 200
LLMTEPSGQF MPYYAVAIGQ GGYTATEYFE KNYREDLNMQ DTILLGIRAL
210 220 230 240
ASTLKPGEKL APSNIEVGFA DVDSGMFRKM SFEERASILQ KL
Sequence cautioni
The sequence BAB65436 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000023 Genomic DNA. Translation: BAB65436.1. Different initiation. |
RefSeqi | WP_052846326.1. NC_003106.2. |
Genome annotation databases
EnsemblBacteriai | BAB65436; BAB65436; STK_04460. |
GeneIDi | 1458383. |
KEGGi | sto:STK_04460. |
PATRICi | fig|273063.9.peg.518. |
Similar proteinsi
Entry informationi
Entry namei | PSA_SULTO | |
Accessioni | Q975G5Primary (citable) accession number: Q975G5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 6, 2002 |
Last sequence update: | June 6, 2002 | |
Last modified: | February 28, 2018 | |
This is version 98 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |