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Protein

RNA 3'-terminal phosphate cyclase

Gene

rtcA

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.UniRule annotation

Catalytic activityi

ATP + (RNA)-3'-(3'-phospho-ribonucleoside) = AMP + diphosphate + (RNA)-3'-(2',3'-cyclophospho)-ribonucleoside.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei101ATPUniRule annotation1
Active sitei307Tele-AMP-histidine intermediateUniRule annotation1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi283 – 286ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTOK273063:G1G3D-671-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
RNA 3'-terminal phosphate cyclaseUniRule annotation (EC:6.5.1.4UniRule annotation)
Short name:
RNA cyclaseUniRule annotation
Short name:
RNA-3'-phosphate cyclaseUniRule annotation
Gene namesi
Name:rtcAUniRule annotation
Ordered Locus Names:STK_05700
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001564371 – 339RNA 3'-terminal phosphate cyclaseAdd BLAST339

Proteomic databases

PRIDEiQ974U1

Interactioni

Protein-protein interaction databases

STRINGi273063.ST0570

Structurei

3D structure databases

ProteinModelPortaliQ974U1
SMRiQ974U1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04125 Archaea
COG0430 LUCA
HOGENOMiHOG000015264
KOiK01974
OMAiANRPKPG
OrthoDBiPOG093Z05RD

Family and domain databases

Gene3Di3.30.360.20, 1 hit
3.65.10.20, 2 hits
HAMAPiMF_00200 RTC, 1 hit
InterProiView protein in InterPro
IPR013791 RNA3'-term_phos_cycl_insert
IPR023797 RNA3'_phos_cyclase_dom
IPR037136 RNA3'_phos_cyclase_dom_sf
IPR000228 RNA3'_term_phos_cyc
IPR017770 RNA3'_term_phos_cyc_type_1
IPR020719 RNA3'_term_phos_cycl-like_CS
IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b
IPR036553 RPTC_insert
PANTHERiPTHR11096 PTHR11096, 1 hit
PTHR11096:SF0 PTHR11096:SF0, 1 hit
PfamiView protein in Pfam
PF01137 RTC, 1 hit
PF05189 RTC_insert, 1 hit
PIRSFiPIRSF005378 RNA3'_term_phos_cycl_euk, 1 hit
SUPFAMiSSF55205 SSF55205, 1 hit
TIGRFAMsiTIGR03399 RNA_3prim_cycl, 1 hit
PROSITEiView protein in PROSITE
PS01287 RTC, 1 hit

Sequencei

Sequence statusi: Complete.

Q974U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEIDGSFGE GGGQILRTSL TLSALTKKPF RIYKIRANRP KPGLQRQHLT
60 70 80 90 100
AVEAVKKLTN AKVKGDFVGS TELVFEPEDI VEKGDFEFDV GTAGSVTLIL
110 120 130 140 150
QTILPLLINR NIKVTIKGGT DVPKSPSIDY IRLTFLSLLE KIGIRVNLIL
160 170 180 190 200
IRRGHYPEGG GEIKITEVKG NPSSFSLMER GELLMIKGIS HVSSLPSHIA
210 220 230 240 250
ERQAKSAKEF LLSKIKIPVE IEIDVRENER SKGSGIALTA IFEKTFLGSD
260 270 280 290 300
SLGEKGKRAE IVGEEAAKSI YEEIISNATV DRHMSDMLML YASLYYGEYI
310 320 330
GSELTSHART NSEIIKKFLN VNIQISGEKP FIFRAKKEL
Length:339
Mass (Da):37,505
Last modified:December 1, 2001 - v1
Checksum:iC49582296471599D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA Translation: BAB65566.1
RefSeqiWP_010978549.1, NC_003106.2

Genome annotation databases

EnsemblBacteriaiBAB65566; BAB65566; STK_05700
GeneIDi1458516
KEGGisto:STK_05700
PATRICifig|273063.9.peg.652

Similar proteinsi

Entry informationi

Entry nameiRTCA_SULTO
AccessioniPrimary (citable) accession number: Q974U1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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