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Q974T4 (GUAAA_SULTO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP synthase [glutamine-hydrolyzing] subunit A

EC=6.3.5.2
Alternative name(s):
Glutamine amidotransferase
Gene names
Name:guaAA
Ordered Locus Names:STK_05780
OrganismSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) [Complete proteome] [HAMAP]
Taxonomic identifier273063 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length188 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of GMP from XMP By similarity. HAMAP MF_01510

Catalytic activity

ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP MF_01510

Pathway

Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP MF_01510

Subunit structure

Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B) Potential.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 188188GMP synthase [glutamine-hydrolyzing] subunit A HAMAP MF_01510
PRO_0000140234

Regions

Domain2 – 188187Glutamine amidotransferase type-1

Sites

Active site791Nucleophile By similarity
Active site1661 By similarity
Active site1681 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q974T4 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: E2ED1409668B536D

FASTA18820,828
        10         20         30         40         50         60 
MKIAVIYFGG QYNHLIVKDL KYLGLNAVLI TPEKPVEILK DYDCIIFGGG PYSVITELNK 

        70         80         90        100        110        120 
MGNAVDYVLR TSQPKLGICL GHQLLAKVLG GEVTKATKPE YGLVKVNIND EDTILRGLSP 

       130        140        150        160        170        180 
SINAWESHTD EVISPPQGFR ILANSENAKV QAMVNKDNTI FGVQFHPEVK HTEKGIEVFK 


NFIEACKK 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000023 Genomic DNA. Translation: BAK54335.1.
RefSeqNP_376464.1. NC_003106.2.

3D structure databases

ProteinModelPortalQ974T4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1458523.
GenomeReviewsGene locus ST0578 in contig BA000023_GR.
KEGGsto:ST0578.
NMPDRfig|273063.1.peg.632.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG292341.
OMAGQYVHRI.
PhylomeDBQ974T4.
ProtClustDBPRK00758.

Enzyme and pathway databases

BioCycSTOK273063:ST0578-MONOMER.

Family and domain databases

HAMAPMF_01510. GMP_synthase_A.
[Tree]
InterProIPR017926. GATASE_1.
IPR004739. GMP_synth_N.
IPR023686. GMP_synthase_A.
[Graphical view]
KOK01951.
PfamPF00117. GATase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00888. GuaA_Nterm. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAAA_SULTO
AccessionPrimary (citable) accession number: Q974T4
Secondary accession number(s): F9VN38
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: December 1, 2001
Last modified: January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families