Reviewed,
UniProtKB/Swiss-Prot Q974T4 (GUAAA_SULTO)
Last modified
February 9, 2010.
Version 54.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: GMP synthase [glutamine-hydrolyzing] subunit A EC=6.3.5.2 Alternative name(s): Glutamine amidotransferase | ||||
| Gene names |
| ||||
| Organism | Sulfolobus tokodaii [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 111955 [NCBI] | ||||
| Taxonomic lineage | Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus |
Protein attributes
| Sequence length | 188 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the synthesis of GMP from XMP By similarity. HAMAP MF_01510 |
| Catalytic activity | ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP MF_01510 |
| Pathway | Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP MF_01510 |
| Subunit structure | Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B) Potential. HAMAP MF_01510 |
| Sequence similarities | Contains 1 glutamine amidotransferase type-1 domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | GMP biosynthesis Purine biosynthesis |
| Domain | Glutamine amidotransferase |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | GMP biosynthetic process Inferred from electronic annotation. Source: HAMAP glutamine metabolic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW GMP synthase (glutamine-hydrolyzing) activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 188 | 188 | GMP synthase [glutamine-hydrolyzing] subunit A HAMAP MF_01510 | PRO_0000140234 | |||||
Regions | |||||||||
| Domain | 2 – 188 | 187 | Glutamine amidotransferase type-1 | ||||||
Sites | |||||||||
| Active site | 79 | 1 | Nucleophile By similarity | ||||||
| Active site | 166 | 1 | By similarity | ||||||
| Active site | 168 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of an aerobic thermoacidophilic Crenarchaeon, Sulfolobus tokodaii strain7." Kawarabayasi Y., Hino Y., Horikawa H., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Otsuka R., Nakazawa H., Takamiya M., Kato Y., Yoshizawa T. Kikuchi H.DNA Res. 8:123-140(2001) [PubMed: 11572479] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BA000023 Genomic DNA. Translation: BAB65573.1. |
| RefSeq | NP_376464.1. |
3D structure databases | |
| SMR | Q974T4. Positions 2-187. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1458523. |
| GenomeReviews | Gene locus ST0578 in contig BA000023_GR. |
| KEGG | sto:ST0578. |
| NMPDR | fig|273063.1.peg.632. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG292341. |
| OMA | GQYVHRI. |
Enzyme and pathway databases | |
| BioCyc | STOK273063:ST0578-MONOMER. |
| BRENDA | 6.3.5.2. 261167. |
Family and domain databases | |
| HAMAP | MF_01510. GMP_synthase_A. [Tree] |
| InterPro | IPR006220. Anth_synthII. IPR011702. GATASE. IPR017926. GATASE_1. IPR000991. GATase_class1_C. IPR004739. GMP_synth_N. [Graphical view] |
| Pfam | PF00117. GATase. 1 hit. [Graphical view] |
| PRINTS | PR00097. ANTSNTHASEII. PR00096. GATASE. |
| TIGRFAMs | TIGR00888. guaA_Nterm. 1 hit. |
| PROSITE | PS51273. GATASE_TYPE_1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GUAAA_SULTO | ||||||||
| Accession | Primary (citable) accession number: Q974T4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


