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Q974N4

- SYL1_SULTO

UniProt

Q974N4 - SYL1_SULTO

Protein

Leucine--tRNA ligase 1

Gene

leuS1

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei628 – 6281ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSTOK273063:GJC7-710-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligase 1UniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetase 1UniRule annotation
    Short name:
    LeuRS 1UniRule annotation
    Gene namesi
    Name:leuS1UniRule annotation
    Ordered Locus Names:STK_06250
    OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
    Taxonomic identifieri273063 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001015: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 945945Leucine--tRNA ligase 1PRO_0000152146Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273063.ST0625.

    Structurei

    3D structure databases

    ProteinModelPortaliQ974N4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi625 – 6295"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000216620.
    KOiK01869.
    OMAiQFTGTPI.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 2 hits.
    HAMAPiMF_00049_A. Leu_tRNA_synth_A.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q974N4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLANFFNEI AFKWQKEWEN SKVYEANPET DKPKKFITVA FPYTNSPLHI    50
    GHGRTYITAD IYARYLRMKG YNVLFPFAFQ FTGTPILSIS ESVKRGDEEI 100
    ISTFVNIYQI PKEEIEKFSD PTYLAEYFKN NMKNTAKKLG LGIDWRREFT 150
    TVDPIFEKFV QWQYRKLMEL GYIKREDSPV AYCPRDEFPV GMHDTKGDVE 200
    PEITDLDGIY FPSGDYFFIA ATPRPETIFG AVALLVNPEA DYVIATDSLN 250
    RKVIISRQAY DKLKYQISFR EEGEKKGKDL VGMIAKNPVT EKEIKVLPSK 300
    FVDPSIGTGV VMAVPSHEPL HYIALTELKE EFELIPVIKT DELGELPGVE 350
    AVGLAQTRNP AELKDYIDTI YRIEYHKGIM REDLVDLVPN FMKEFVKDKI 400
    AGKLVKDARE KTRELLDMLN SRITIYEISN GPVYCRCGAE IVVKVIKGQW 450
    FIDYSNPIWK TSVLKSLDKI NFIPTDSKKE MEKIIFNLQP RAFTRSRGLG 500
    VRLPWDEKEI IDSLSDSTIY TAFYTIVHKL KYPISLLSDK FWDYILLDRG 550
    TADEISKELG IPKEQLEEIK SEFKYWYPVD SRHSGRDLIQ NHLPYYLFHH 600
    FAIFGEKFLP RQIVTNGFIR VGGKKMSKSF GNIYPLNRAI DEYGVETVRI 650
    ALTSTSSISD DIEFNSNIAK SIAEQLKKIH DLISKLLEIE GVNERRDPDV 700
    WLLSIFRRYI EDVDKAYENL DLRTVYMTVY YTIYETIKDY IELTNAKINK 750
    DIIKKVISIW LRLMAPITPH LAEELWHKMS NTFVVKEKFP SINEVEYNEK 800
    SLLKVEYLRS IIEDVNRLSS ELGKEAEKVV IYVNDDNNLR ELLKKAIIAI 850
    KDRKSLRDFM IENNVDDKTA RRIYELANVL PSTIRDLIVT TDIDEEEVIV 900
    QNINFLMNKL DLREMIVYSS TDEKAPNILG KKDLALPYKP GIAIL 945
    Length:945
    Mass (Da):109,513
    Last modified:December 1, 2001 - v1
    Checksum:i7DEA1C56838C0AF9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000023 Genomic DNA. Translation: BAK54356.1.
    RefSeqiNP_376514.1. NC_003106.2.

    Genome annotation databases

    EnsemblBacteriaiBAK54356; BAK54356; STK_06250.
    GeneIDi1458573.
    KEGGisto:ST0625.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000023 Genomic DNA. Translation: BAK54356.1 .
    RefSeqi NP_376514.1. NC_003106.2.

    3D structure databases

    ProteinModelPortali Q974N4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273063.ST0625.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAK54356 ; BAK54356 ; STK_06250 .
    GeneIDi 1458573.
    KEGGi sto:ST0625.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000216620.
    KOi K01869.
    OMAi QFTGTPI.

    Enzyme and pathway databases

    BioCyci STOK273063:GJC7-710-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 2 hits.
    HAMAPi MF_00049_A. Leu_tRNA_synth_A.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

    Entry informationi

    Entry nameiSYL1_SULTO
    AccessioniPrimary (citable) accession number: Q974N4
    Secondary accession number(s): F9VN59
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3