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Q974N4

- SYL1_SULTO

UniProt

Q974N4 - SYL1_SULTO

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Protein

Leucine--tRNA ligase 1

Gene
leuS1, STK_06250
Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei628 – 6281ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-710-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase 1 (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase 1
Short name:
LeuRS 1
Gene namesi
Name:leuS1
Ordered Locus Names:STK_06250
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001015: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 945945Leucine--tRNA ligase 1UniRule annotationPRO_0000152146Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273063.ST0625.

Structurei

3D structure databases

ProteinModelPortaliQ974N4.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi625 – 6295"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiQFTGTPI.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q974N4-1 [UniParc]FASTAAdd to Basket

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MSLANFFNEI AFKWQKEWEN SKVYEANPET DKPKKFITVA FPYTNSPLHI    50
GHGRTYITAD IYARYLRMKG YNVLFPFAFQ FTGTPILSIS ESVKRGDEEI 100
ISTFVNIYQI PKEEIEKFSD PTYLAEYFKN NMKNTAKKLG LGIDWRREFT 150
TVDPIFEKFV QWQYRKLMEL GYIKREDSPV AYCPRDEFPV GMHDTKGDVE 200
PEITDLDGIY FPSGDYFFIA ATPRPETIFG AVALLVNPEA DYVIATDSLN 250
RKVIISRQAY DKLKYQISFR EEGEKKGKDL VGMIAKNPVT EKEIKVLPSK 300
FVDPSIGTGV VMAVPSHEPL HYIALTELKE EFELIPVIKT DELGELPGVE 350
AVGLAQTRNP AELKDYIDTI YRIEYHKGIM REDLVDLVPN FMKEFVKDKI 400
AGKLVKDARE KTRELLDMLN SRITIYEISN GPVYCRCGAE IVVKVIKGQW 450
FIDYSNPIWK TSVLKSLDKI NFIPTDSKKE MEKIIFNLQP RAFTRSRGLG 500
VRLPWDEKEI IDSLSDSTIY TAFYTIVHKL KYPISLLSDK FWDYILLDRG 550
TADEISKELG IPKEQLEEIK SEFKYWYPVD SRHSGRDLIQ NHLPYYLFHH 600
FAIFGEKFLP RQIVTNGFIR VGGKKMSKSF GNIYPLNRAI DEYGVETVRI 650
ALTSTSSISD DIEFNSNIAK SIAEQLKKIH DLISKLLEIE GVNERRDPDV 700
WLLSIFRRYI EDVDKAYENL DLRTVYMTVY YTIYETIKDY IELTNAKINK 750
DIIKKVISIW LRLMAPITPH LAEELWHKMS NTFVVKEKFP SINEVEYNEK 800
SLLKVEYLRS IIEDVNRLSS ELGKEAEKVV IYVNDDNNLR ELLKKAIIAI 850
KDRKSLRDFM IENNVDDKTA RRIYELANVL PSTIRDLIVT TDIDEEEVIV 900
QNINFLMNKL DLREMIVYSS TDEKAPNILG KKDLALPYKP GIAIL 945
Length:945
Mass (Da):109,513
Last modified:December 1, 2001 - v1
Checksum:i7DEA1C56838C0AF9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000023 Genomic DNA. Translation: BAK54356.1.
RefSeqiNP_376514.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAK54356; BAK54356; STK_06250.
GeneIDi1458573.
KEGGisto:ST0625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000023 Genomic DNA. Translation: BAK54356.1 .
RefSeqi NP_376514.1. NC_003106.2.

3D structure databases

ProteinModelPortali Q974N4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273063.ST0625.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAK54356 ; BAK54356 ; STK_06250 .
GeneIDi 1458573.
KEGGi sto:ST0625.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi QFTGTPI.

Enzyme and pathway databases

BioCyci STOK273063:GJC7-710-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

Entry informationi

Entry nameiSYL1_SULTO
AccessioniPrimary (citable) accession number: Q974N4
Secondary accession number(s): F9VN59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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