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Q974N4 (SYL1_SULTO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase 1

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase 1
Short name=LeuRS 1
Gene names
Name:leuS1
Ordered Locus Names:STK_06250
OrganismSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) [Complete proteome] [HAMAP]
Taxonomic identifier273063 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length945 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 945945Leucine--tRNA ligase 1 HAMAP-Rule MF_00049
PRO_0000152146

Regions

Motif42 – 5211"HIGH" region HAMAP-Rule MF_00049
Motif625 – 6295"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6281ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q974N4 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 7DEA1C56838C0AF9

FASTA945109,513
        10         20         30         40         50         60 
MSLANFFNEI AFKWQKEWEN SKVYEANPET DKPKKFITVA FPYTNSPLHI GHGRTYITAD 

        70         80         90        100        110        120 
IYARYLRMKG YNVLFPFAFQ FTGTPILSIS ESVKRGDEEI ISTFVNIYQI PKEEIEKFSD 

       130        140        150        160        170        180 
PTYLAEYFKN NMKNTAKKLG LGIDWRREFT TVDPIFEKFV QWQYRKLMEL GYIKREDSPV 

       190        200        210        220        230        240 
AYCPRDEFPV GMHDTKGDVE PEITDLDGIY FPSGDYFFIA ATPRPETIFG AVALLVNPEA 

       250        260        270        280        290        300 
DYVIATDSLN RKVIISRQAY DKLKYQISFR EEGEKKGKDL VGMIAKNPVT EKEIKVLPSK 

       310        320        330        340        350        360 
FVDPSIGTGV VMAVPSHEPL HYIALTELKE EFELIPVIKT DELGELPGVE AVGLAQTRNP 

       370        380        390        400        410        420 
AELKDYIDTI YRIEYHKGIM REDLVDLVPN FMKEFVKDKI AGKLVKDARE KTRELLDMLN 

       430        440        450        460        470        480 
SRITIYEISN GPVYCRCGAE IVVKVIKGQW FIDYSNPIWK TSVLKSLDKI NFIPTDSKKE 

       490        500        510        520        530        540 
MEKIIFNLQP RAFTRSRGLG VRLPWDEKEI IDSLSDSTIY TAFYTIVHKL KYPISLLSDK 

       550        560        570        580        590        600 
FWDYILLDRG TADEISKELG IPKEQLEEIK SEFKYWYPVD SRHSGRDLIQ NHLPYYLFHH 

       610        620        630        640        650        660 
FAIFGEKFLP RQIVTNGFIR VGGKKMSKSF GNIYPLNRAI DEYGVETVRI ALTSTSSISD 

       670        680        690        700        710        720 
DIEFNSNIAK SIAEQLKKIH DLISKLLEIE GVNERRDPDV WLLSIFRRYI EDVDKAYENL 

       730        740        750        760        770        780 
DLRTVYMTVY YTIYETIKDY IELTNAKINK DIIKKVISIW LRLMAPITPH LAEELWHKMS 

       790        800        810        820        830        840 
NTFVVKEKFP SINEVEYNEK SLLKVEYLRS IIEDVNRLSS ELGKEAEKVV IYVNDDNNLR 

       850        860        870        880        890        900 
ELLKKAIIAI KDRKSLRDFM IENNVDDKTA RRIYELANVL PSTIRDLIVT TDIDEEEVIV 

       910        920        930        940 
QNINFLMNKL DLREMIVYSS TDEKAPNILG KKDLALPYKP GIAIL 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000023 Genomic DNA. Translation: BAK54356.1.
RefSeqNP_376514.1. NC_003106.2.

3D structure databases

ProteinModelPortalQ974N4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273063.ST0625.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAK54356; BAK54356; STK_06250.
GeneID1458573.
KEGGsto:ST0625.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000216620.
KOK01869.
OMAQFTGTPI.

Enzyme and pathway databases

BioCycSTOK273063:GJC7-710-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
HAMAPMF_00049_A. Leu_tRNA_synth_A.
InterProIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsTIGR00395. leuS_arch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYL1_SULTO
AccessionPrimary (citable) accession number: Q974N4
Secondary accession number(s): F9VN59
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries