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Protein

Leucine--tRNA ligase 1

Gene

leuS1

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei628ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTOK273063:G1G3D-728-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase 1UniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetase 1UniRule annotation
Short name:
LeuRS 1UniRule annotation
Gene namesi
Name:leuS1UniRule annotation
Ordered Locus Names:STK_06250
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001521461 – 945Leucine--tRNA ligase 1Add BLAST945

Interactioni

Protein-protein interaction databases

STRINGi273063.ST0625

Structurei

3D structure databases

ProteinModelPortaliQ974N4
SMRiQ974N4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi625 – 629"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
HOGENOMiHOG000216620
KOiK01869
OMAiIVKDRRY
OrthoDBiPOG093Z006D

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF09334 tRNA-synt_1g, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit

Sequencei

Sequence statusi: Complete.

Q974N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLANFFNEI AFKWQKEWEN SKVYEANPET DKPKKFITVA FPYTNSPLHI
60 70 80 90 100
GHGRTYITAD IYARYLRMKG YNVLFPFAFQ FTGTPILSIS ESVKRGDEEI
110 120 130 140 150
ISTFVNIYQI PKEEIEKFSD PTYLAEYFKN NMKNTAKKLG LGIDWRREFT
160 170 180 190 200
TVDPIFEKFV QWQYRKLMEL GYIKREDSPV AYCPRDEFPV GMHDTKGDVE
210 220 230 240 250
PEITDLDGIY FPSGDYFFIA ATPRPETIFG AVALLVNPEA DYVIATDSLN
260 270 280 290 300
RKVIISRQAY DKLKYQISFR EEGEKKGKDL VGMIAKNPVT EKEIKVLPSK
310 320 330 340 350
FVDPSIGTGV VMAVPSHEPL HYIALTELKE EFELIPVIKT DELGELPGVE
360 370 380 390 400
AVGLAQTRNP AELKDYIDTI YRIEYHKGIM REDLVDLVPN FMKEFVKDKI
410 420 430 440 450
AGKLVKDARE KTRELLDMLN SRITIYEISN GPVYCRCGAE IVVKVIKGQW
460 470 480 490 500
FIDYSNPIWK TSVLKSLDKI NFIPTDSKKE MEKIIFNLQP RAFTRSRGLG
510 520 530 540 550
VRLPWDEKEI IDSLSDSTIY TAFYTIVHKL KYPISLLSDK FWDYILLDRG
560 570 580 590 600
TADEISKELG IPKEQLEEIK SEFKYWYPVD SRHSGRDLIQ NHLPYYLFHH
610 620 630 640 650
FAIFGEKFLP RQIVTNGFIR VGGKKMSKSF GNIYPLNRAI DEYGVETVRI
660 670 680 690 700
ALTSTSSISD DIEFNSNIAK SIAEQLKKIH DLISKLLEIE GVNERRDPDV
710 720 730 740 750
WLLSIFRRYI EDVDKAYENL DLRTVYMTVY YTIYETIKDY IELTNAKINK
760 770 780 790 800
DIIKKVISIW LRLMAPITPH LAEELWHKMS NTFVVKEKFP SINEVEYNEK
810 820 830 840 850
SLLKVEYLRS IIEDVNRLSS ELGKEAEKVV IYVNDDNNLR ELLKKAIIAI
860 870 880 890 900
KDRKSLRDFM IENNVDDKTA RRIYELANVL PSTIRDLIVT TDIDEEEVIV
910 920 930 940
QNINFLMNKL DLREMIVYSS TDEKAPNILG KKDLALPYKP GIAIL
Length:945
Mass (Da):109,513
Last modified:December 1, 2001 - v1
Checksum:i7DEA1C56838C0AF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA Translation: BAK54356.1
RefSeqiWP_010978606.1, NC_003106.2

Genome annotation databases

EnsemblBacteriaiBAK54356; BAK54356; STK_06250
GeneIDi1458573
KEGGisto:STK_06250
PATRICifig|273063.9.peg.709

Similar proteinsi

Entry informationi

Entry nameiSYL1_SULTO
AccessioniPrimary (citable) accession number: Q974N4
Secondary accession number(s): F9VN59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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