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Protein

Nicotinamide-nucleotide adenylyltransferase

Gene

STK_06480

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + nicotinamide ribonucleotide = diphosphate + NAD+.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes NAD(+) from nicotinamide D-ribonucleotide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinamide-nucleotide adenylyltransferase (STK_03020), Nicotinamide-nucleotide adenylyltransferase (STK_06480)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes NAD(+) from nicotinamide D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00600.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinamide-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.1UniRule annotation)
Alternative name(s):
NAD(+) diphosphorylaseUniRule annotation
NAD(+) pyrophosphorylaseUniRule annotation
NMN adenylyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:STK_06480
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Nicotinamide-nucleotide adenylyltransferasePRO_0000135006Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273063.ST0648.

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal NMN adenylyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00972. Archaea.
COG1056. LUCA.
HOGENOMiHOG000108858.
KOiK00952.
OMAiNWIRIVE.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00243. NMN_adenylyltr. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR006418. NMN_Atrans_arc.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01527. arch_NMN_Atrans. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

Q974L1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVFPGRFQ PFHLGHLAVI EWLLSKYDEL IIVVGSGKDS HTIYNPFTAG
60 70 80 90 100
ERILMIKKGL KEFNVDFTRV IFFPIMDSFT SGLWIRNLEL YSPKFDVVVS
110 120 130 140 150
GNPLVISDAR EAGYIVDLPP MFNREMYNAT KIRKLMLENN ESWSELVPKS
160 170
VYSFIKEIKG DERLRDIARN DY
Length:172
Mass (Da):19,956
Last modified:December 14, 2011 - v2
Checksum:iB767B0334866F1E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54361.1.
RefSeqiWP_052846904.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAK54361; BAK54361; STK_06480.
GeneIDi1458597.
KEGGisto:STK_06480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54361.1.
RefSeqiWP_052846904.1. NC_003106.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273063.ST0648.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAK54361; BAK54361; STK_06480.
GeneIDi1458597.
KEGGisto:STK_06480.

Phylogenomic databases

eggNOGiarCOG00972. Archaea.
COG1056. LUCA.
HOGENOMiHOG000108858.
KOiK00952.
OMAiNWIRIVE.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00600.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00243. NMN_adenylyltr. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR006418. NMN_Atrans_arc.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01527. arch_NMN_Atrans. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADM_SULTO
AccessioniPrimary (citable) accession number: Q974L1
Secondary accession number(s): F9VN64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: December 14, 2011
Last modified: December 9, 2015
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.