Q973G0 (IF2A_SULTO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Translation initiation factor 2 subunit alpha

Alternative name(s):
aIF2-alpha
eIF-2-alpha

Gene names

Name:	eif2a
Ordered Locus Names:	STK_09410

Organism

Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) [Complete proteome] [HAMAP]

Taxonomic identifier

273063 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus › Sulfolobus tokodaii

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA By similarity. HAMAP-Rule MF_00231
Subunit structure	Heterotrimer composed of an alpha, a beta and a gamma chain By similarity.
Sequence similarities	Belongs to the eIF-2-alpha family. Contains 1 S1 motif domain.

Ontologies

Keywords
Biological process	Protein biosynthesis
Ligand	RNA-binding
Molecular function	Initiation factor
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	eukaryotic translation initiation factor 2 complex Inferred from electronic annotation. Source: InterPro
Molecular_function	translation initiation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 263	263	Translation initiation factor 2 subunit alpha HAMAP-Rule MF_00231		PRO_0000137403
Regions
	Domain	12 – 83	72	S1 motif

Sequences

	Sequence		Length	Mass (Da)
	Q973G0 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: ACF12013C64C6497	FASTA	263	30,222
	10 20 30 40 50 60 MIYNKNPIPT EGEILIATVK QIFDYGSYVT LDEYGNLQAF LPWSEISSRW VKNIRDVIKE 70 80 90 100 110 120 GRKIVVKVIR VDKRKGTIDV SLKKVTEDEK RKKMSQWKKI QKVDKILEIV SQKINKTEKE 130 140 150 160 170 180 GWEQVAWKLE DKYGDAYDAL VKAVKEGDSI LKNAGVPEVW IKPLMEEIGK HIEEKRVKKS 190 200 210 220 230 240 EIVTLRSSDP AGIEKIRKVL GAAVEIAENA DVDIKIYTIG APRYRIDIIG TDPKLLSKVM 250 260 TEILDNIREI SKEEKVEFNV VRK

References

[1]

"Complete genome sequence of an aerobic thermoacidophilic Crenarchaeon, Sulfolobus tokodaii strain7." Kawarabayasi Y., Hino Y., Horikawa H., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Otsuka R., Nakazawa H., Takamiya M., Kato Y., Yoshizawa T. , Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Masuda S., Yanagii M., Nishimura M., Yamagishi A., Oshima T., Kikuchi H. DNA Res. 8:123-140(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000023 Genomic DNA. Translation: BAB65953.1.
RefSeq	NP_376844.1. NC_003106.2.
3D structure databases
ProteinModelPortal	Q973G0.
SMR	Q973G0. Positions 1-261.
ModBase	Search...
Protein-protein interaction databases
STRING	273063.ST0941.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAB65953; BAB65953; STK_09410.
GeneID	1458904.
KEGG	sto:ST0941.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1093.
HOGENOM	HOG000224965.
KO	K03237.
OMA	KDVNEHQ.
ProtClustDB	PRK03987.
Family and domain databases
Gene3D	1.10.150.190. 1 hit. 2.40.50.140. 1 hit. 3.30.70.1130. 1 hit.
HAMAP	MF_00231. eIF-2-alpha.
InterPro	IPR012340. NA-bd_OB-fold. IPR003029. Rbsml_prot_S1_RNA-bd_dom. IPR022967. RNA-binding_domain_S1. IPR022964. TIF2_asu_arc. IPR024055. TIF2_asu_C. IPR024054. TIF2_asu_middle. IPR011488. TIF_2_asu. [Graphical view]
Pfam	PF07541. EIF_2_alpha. 1 hit. PF00575. S1. 1 hit. [Graphical view]
SMART	SM00316. S1. 1 hit. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit. SSF110993. SSF110993. 1 hit. SSF116742. SSF116742. 1 hit.
PROSITE	PS50126. S1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IF2A_SULTO

Accession

Primary (citable) accession number: Q973G0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program