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Q973G0 (IF2A_SULTO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor 2 subunit alpha
Alternative name(s):
aIF2-alpha
eIF-2-alpha
Gene names
Name:eif2a
Ordered Locus Names:STK_09410
OrganismSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) [Complete proteome] [HAMAP]
Taxonomic identifier273063 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA By similarity. HAMAP-Rule MF_00231

Subunit structure

Heterotrimer composed of an alpha, a beta and a gamma chain By similarity.

Sequence similarities

Belongs to the eIF-2-alpha family.

Contains 1 S1 motif domain.

Ontologies

Keywords
   Biological processProtein biosynthesis
   LigandRNA-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componenteukaryotic translation initiation factor 2 complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functiontranslation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 263263Translation initiation factor 2 subunit alpha HAMAP-Rule MF_00231
PRO_0000137403

Regions

Domain12 – 8372S1 motif

Sequences

Sequence LengthMass (Da)Tools
Q973G0 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: ACF12013C64C6497

FASTA26330,222
        10         20         30         40         50         60 
MIYNKNPIPT EGEILIATVK QIFDYGSYVT LDEYGNLQAF LPWSEISSRW VKNIRDVIKE 

        70         80         90        100        110        120 
GRKIVVKVIR VDKRKGTIDV SLKKVTEDEK RKKMSQWKKI QKVDKILEIV SQKINKTEKE 

       130        140        150        160        170        180 
GWEQVAWKLE DKYGDAYDAL VKAVKEGDSI LKNAGVPEVW IKPLMEEIGK HIEEKRVKKS 

       190        200        210        220        230        240 
EIVTLRSSDP AGIEKIRKVL GAAVEIAENA DVDIKIYTIG APRYRIDIIG TDPKLLSKVM 

       250        260 
TEILDNIREI SKEEKVEFNV VRK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000023 Genomic DNA. Translation: BAB65953.1.
RefSeqNP_376844.1. NC_003106.2.

3D structure databases

ProteinModelPortalQ973G0.
SMRQ973G0. Positions 1-261.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273063.ST0941.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB65953; BAB65953; STK_09410.
GeneID1458904.
KEGGsto:ST0941.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1093.
HOGENOMHOG000224965.
KOK03237.
OMAIDAEFEI.

Enzyme and pathway databases

BioCycSTOK273063:GJC7-1041-MONOMER.

Family and domain databases

Gene3D1.10.150.190. 1 hit.
2.40.50.140. 1 hit.
3.30.70.1130. 1 hit.
HAMAPMF_00231. eIF_2_alpha.
InterProIPR012340. NA-bd_OB-fold.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR022967. RNA-binding_domain_S1.
IPR022964. TIF2_asu_arc.
IPR024055. TIF2_asu_C.
IPR024054. TIF2_asu_middle.
IPR011488. TIF_2_asu.
[Graphical view]
PfamPF07541. EIF_2_alpha. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
SMARTSM00316. S1. 1 hit.
[Graphical view]
SUPFAMSSF110993. SSF110993. 1 hit.
SSF116742. SSF116742. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEPS50126. S1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2A_SULTO
AccessionPrimary (citable) accession number: Q973G0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries