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Q973G0

- IF2A_SULTO

UniProt

Q973G0 - IF2A_SULTO

Protein

Translation initiation factor 2 subunit alpha

Gene

eif2a

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.UniRule annotation

    GO - Molecular functioni

    1. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciSTOK273063:GJC7-1041-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor 2 subunit alphaUniRule annotation
    Alternative name(s):
    aIF2-alphaUniRule annotation
    eIF-2-alphaUniRule annotation
    Gene namesi
    Name:eif2aUniRule annotation
    Ordered Locus Names:STK_09410
    OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
    Taxonomic identifieri273063 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001015: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. eukaryotic translation initiation factor 2 complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 263263Translation initiation factor 2 subunit alphaPRO_0000137403Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotrimer composed of an alpha, a beta and a gamma chain.UniRule annotation

    Protein-protein interaction databases

    STRINGi273063.ST0941.

    Structurei

    3D structure databases

    ProteinModelPortaliQ973G0.
    SMRiQ973G0. Positions 1-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 8372S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the eIF-2-alpha family.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1093.
    HOGENOMiHOG000224965.
    KOiK03237.
    OMAiIDAEFEI.

    Family and domain databases

    Gene3Di1.10.150.190. 1 hit.
    2.40.50.140. 1 hit.
    3.30.70.1130. 1 hit.
    HAMAPiMF_00231. eIF_2_alpha.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR022967. RNA-binding_domain_S1.
    IPR022964. TIF2_asu_arc.
    IPR024055. TIF2_asu_C.
    IPR024054. TIF2_asu_middle.
    IPR011488. TIF_2_asu.
    [Graphical view]
    PfamiPF07541. EIF_2_alpha. 1 hit.
    PF00575. S1. 1 hit.
    [Graphical view]
    SMARTiSM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF110993. SSF110993. 1 hit.
    SSF116742. SSF116742. 1 hit.
    SSF50249. SSF50249. 1 hit.
    PROSITEiPS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q973G0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIYNKNPIPT EGEILIATVK QIFDYGSYVT LDEYGNLQAF LPWSEISSRW    50
    VKNIRDVIKE GRKIVVKVIR VDKRKGTIDV SLKKVTEDEK RKKMSQWKKI 100
    QKVDKILEIV SQKINKTEKE GWEQVAWKLE DKYGDAYDAL VKAVKEGDSI 150
    LKNAGVPEVW IKPLMEEIGK HIEEKRVKKS EIVTLRSSDP AGIEKIRKVL 200
    GAAVEIAENA DVDIKIYTIG APRYRIDIIG TDPKLLSKVM TEILDNIREI 250
    SKEEKVEFNV VRK 263
    Length:263
    Mass (Da):30,222
    Last modified:December 1, 2001 - v1
    Checksum:iACF12013C64C6497
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000023 Genomic DNA. Translation: BAB65953.1.
    RefSeqiNP_376844.1. NC_003106.2.

    Genome annotation databases

    EnsemblBacteriaiBAB65953; BAB65953; STK_09410.
    GeneIDi1458904.
    KEGGisto:ST0941.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000023 Genomic DNA. Translation: BAB65953.1 .
    RefSeqi NP_376844.1. NC_003106.2.

    3D structure databases

    ProteinModelPortali Q973G0.
    SMRi Q973G0. Positions 1-261.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273063.ST0941.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB65953 ; BAB65953 ; STK_09410 .
    GeneIDi 1458904.
    KEGGi sto:ST0941.

    Phylogenomic databases

    eggNOGi COG1093.
    HOGENOMi HOG000224965.
    KOi K03237.
    OMAi IDAEFEI.

    Enzyme and pathway databases

    BioCyci STOK273063:GJC7-1041-MONOMER.

    Family and domain databases

    Gene3Di 1.10.150.190. 1 hit.
    2.40.50.140. 1 hit.
    3.30.70.1130. 1 hit.
    HAMAPi MF_00231. eIF_2_alpha.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR022967. RNA-binding_domain_S1.
    IPR022964. TIF2_asu_arc.
    IPR024055. TIF2_asu_C.
    IPR024054. TIF2_asu_middle.
    IPR011488. TIF_2_asu.
    [Graphical view ]
    Pfami PF07541. EIF_2_alpha. 1 hit.
    PF00575. S1. 1 hit.
    [Graphical view ]
    SMARTi SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF110993. SSF110993. 1 hit.
    SSF116742. SSF116742. 1 hit.
    SSF50249. SSF50249. 1 hit.
    PROSITEi PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

    Entry informationi

    Entry nameiIF2A_SULTO
    AccessioniPrimary (citable) accession number: Q973G0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Translation initiation factors
      List of translation initiation factor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3