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Protein

Urease subunit alpha

Gene

ureC

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Cofactori

Ni cationUniRule annotationNote: Binds 2 nickel ions per subunit.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit gamma/beta (ureAB), Urease subunit alpha (ureC)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi135Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi137Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi217Nickel 1; via carbamate groupUniRule annotation1
Metal bindingi217Nickel 2; via carbamate groupUniRule annotation1
Binding sitei219SubstrateUniRule annotation1
Metal bindingi246Nickel 2; via pros nitrogenUniRule annotation1
Metal bindingi272Nickel 2; via tele nitrogenUniRule annotation1
Active sitei320Proton donorUniRule annotation1
Metal bindingi360Nickel 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Nickel

Enzyme and pathway databases

BioCyciSTOK273063:G1G3D-1176-MONOMER
UniPathwayiUPA00258; UER00370

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit alphaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit alphaUniRule annotation
Gene namesi
Name:ureCUniRule annotation
Ordered Locus Names:STK_10280
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002341951 – 557Urease subunit alphaAdd BLAST557

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei217N6-carboxylysineUniRule annotation1

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Proteomic databases

PRIDEiQ972W0

Interactioni

Subunit structurei

Heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta) subunits.UniRule annotation

Protein-protein interaction databases

STRINGi273063.ST1028

Structurei

3D structure databases

ProteinModelPortaliQ972W0
SMRiQ972W0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 557UreaseUniRule annotationAdd BLAST428

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00698 Archaea
COG0804 LUCA
HOGENOMiHOG000075064
KOiK01428
OrthoDBiPOG093Z011E

Family and domain databases

Gene3Di2.30.40.10, 2 hits
HAMAPiMF_01953 Urease_alpha, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
IPR011612 Urease_alpha_N_dom
IPR005848 Urease_asu
IPR017951 Urease_asu_c
PANTHERiPTHR43440 PTHR43440, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
PF00449 Urease_alpha, 1 hit
PRINTSiPR01752 UREASE
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 2 hits
TIGRFAMsiTIGR01792 urease_alph, 1 hit
PROSITEiView protein in PROSITE
PS51368 UREASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q972W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRISRERYFE LYGPTEGDKI RLGDTNLYIT IEKDLIAKGD ELVFGAGKTA
60 70 80 90 100
RDGLGLLPNV REEEVMDLII TNVVILDPLL GVIKADIGIK DGLIVGIGHG
110 120 130 140 150
GNPFTMDGVN FVLGSSTEII SGEGLIATPG FIDTHIHWVA PQQVFDALSA
160 170 180 190 200
GFTTLIGGGT GPAEGTKATT VTPGSWNIKI IAESLDYFPL NFALTAKGSS
210 220 230 240 250
SRITMEEVLR NGASGFKIHE DWGAMPRVID ETLTVADEYD VQVTIHTDTS
260 270 280 290 300
NESGYLEDTL NAINGRTIHA YHVEGAGGGH APDIIKICAE PNVLPSSTNP
310 320 330 340 350
TKPYTIHTYE EHLEMLMAVH HLNPKVPEDV AYAESRIREE TMMAEDYLHD
360 370 380 390 400
LGAISMMSSD SQAMGRVGET GIRTFQLAHK MKDLGLIQIN DNERVLRYLA
410 420 430 440 450
KITINPAITH GISDYVGTLA PGHIADIVLW DPRFFPVKPY MVIKGGAITW
460 470 480 490 500
ALMGDTNASI AYAQPVLYKP MFGYYSAKSV SFFFSATDGV ENLSKIVRRR
510 520 530 540 550
VLPVKNTRHL TKKDMKYNDI LPKIEVNPDT YEVKINGIVP KVPPSKSLPL

TQLYFIY
Length:557
Mass (Da):61,123
Last modified:May 2, 2006 - v2
Checksum:iFF7E681303C2846D
GO

Sequence cautioni

The sequence BAB66053 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA Translation: BAB66053.1 Different initiation.
RefSeqiWP_010979035.1, NC_003106.2

Genome annotation databases

EnsemblBacteriaiBAB66053; BAB66053; STK_10280
GeneIDi1459007
KEGGisto:STK_10280
PATRICifig|273063.9.peg.1156

Similar proteinsi

Entry informationi

Entry nameiURE1_SULTO
AccessioniPrimary (citable) accession number: Q972W0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: May 23, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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