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Protein

Urease subunit alpha

Gene

ureC

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Cofactori

Ni cationUniRule annotationNote: Binds 2 nickel ions per subunit.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit gamma/beta (ureAB), Urease subunit alpha (ureC)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi135 – 1351Nickel 1; via tele nitrogenUniRule annotation
Metal bindingi137 – 1371Nickel 1; via tele nitrogenUniRule annotation
Metal bindingi217 – 2171Nickel 1; via carbamate groupUniRule annotation
Metal bindingi217 – 2171Nickel 2; via carbamate groupUniRule annotation
Binding sitei219 – 2191SubstrateUniRule annotation
Metal bindingi246 – 2461Nickel 2; via pros nitrogenUniRule annotation
Metal bindingi272 – 2721Nickel 2; via tele nitrogenUniRule annotation
Active sitei320 – 3201Proton donorUniRule annotation
Metal bindingi360 – 3601Nickel 1UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nickel

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-1144-MONOMER.
UniPathwayiUPA00258; UER00370.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit alphaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit alphaUniRule annotation
Gene namesi
Name:ureCUniRule annotation
Ordered Locus Names:STK_10280
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Urease subunit alphaPRO_0000234195Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei217 – 2171N6-carboxylysineUniRule annotation

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Interactioni

Subunit structurei

Heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta) subunits.UniRule annotation

Protein-protein interaction databases

STRINGi273063.ST1028.

Structurei

3D structure databases

ProteinModelPortaliQ972W0.
SMRiQ972W0. Positions 1-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini130 – 557428UreaseUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the urease family.UniRule annotation
Contains 1 urease domain.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00698. Archaea.
COG0804. LUCA.
HOGENOMiHOG000075064.
KOiK01428.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01953. Urease_alpha. 1 hit.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01792. urease_alph. 1 hit.
PROSITEiPS51368. UREASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q972W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRISRERYFE LYGPTEGDKI RLGDTNLYIT IEKDLIAKGD ELVFGAGKTA
60 70 80 90 100
RDGLGLLPNV REEEVMDLII TNVVILDPLL GVIKADIGIK DGLIVGIGHG
110 120 130 140 150
GNPFTMDGVN FVLGSSTEII SGEGLIATPG FIDTHIHWVA PQQVFDALSA
160 170 180 190 200
GFTTLIGGGT GPAEGTKATT VTPGSWNIKI IAESLDYFPL NFALTAKGSS
210 220 230 240 250
SRITMEEVLR NGASGFKIHE DWGAMPRVID ETLTVADEYD VQVTIHTDTS
260 270 280 290 300
NESGYLEDTL NAINGRTIHA YHVEGAGGGH APDIIKICAE PNVLPSSTNP
310 320 330 340 350
TKPYTIHTYE EHLEMLMAVH HLNPKVPEDV AYAESRIREE TMMAEDYLHD
360 370 380 390 400
LGAISMMSSD SQAMGRVGET GIRTFQLAHK MKDLGLIQIN DNERVLRYLA
410 420 430 440 450
KITINPAITH GISDYVGTLA PGHIADIVLW DPRFFPVKPY MVIKGGAITW
460 470 480 490 500
ALMGDTNASI AYAQPVLYKP MFGYYSAKSV SFFFSATDGV ENLSKIVRRR
510 520 530 540 550
VLPVKNTRHL TKKDMKYNDI LPKIEVNPDT YEVKINGIVP KVPPSKSLPL

TQLYFIY
Length:557
Mass (Da):61,123
Last modified:May 2, 2006 - v2
Checksum:iFF7E681303C2846D
GO

Sequence cautioni

The sequence BAB66053 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAB66053.1. Different initiation.
RefSeqiWP_010979035.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAB66053; BAB66053; STK_10280.
GeneIDi1459007.
KEGGisto:STK_10280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAB66053.1. Different initiation.
RefSeqiWP_010979035.1. NC_003106.2.

3D structure databases

ProteinModelPortaliQ972W0.
SMRiQ972W0. Positions 1-557.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273063.ST1028.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB66053; BAB66053; STK_10280.
GeneIDi1459007.
KEGGisto:STK_10280.

Phylogenomic databases

eggNOGiarCOG00698. Archaea.
COG0804. LUCA.
HOGENOMiHOG000075064.
KOiK01428.

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.
BioCyciSTOK273063:GJC7-1144-MONOMER.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01953. Urease_alpha. 1 hit.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01792. urease_alph. 1 hit.
PROSITEiPS51368. UREASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiURE1_SULTO
AccessioniPrimary (citable) accession number: Q972W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: December 9, 2015
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.