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Q972S7

- PCKG_SULTO

UniProt

Q972S7 - PCKG_SULTO

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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene
pckG, STK_10580
Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei89 – 891Substrate By similarity
Binding sitei213 – 2131Substrate; via amide nitrogen By similarity
Metal bindingi220 – 2201Manganese By similarity
Binding sitei220 – 2201Substrate By similarity
Metal bindingi239 – 2391Manganese; via tele nitrogen By similarity
Binding sitei260 – 2601Substrate By similarity
Active sitei262 – 2621 By similarity
Metal bindingi277 – 2771Manganese By similarity
Binding sitei369 – 3691GTP By similarity
Binding sitei400 – 4001GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-1178-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckG
Ordered Locus Names:STK_10580
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001015: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 602602Phosphoenolpyruvate carboxykinase [GTP]UniRule annotationPRO_0000103623Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273063.ST1058.

Structurei

3D structure databases

ProteinModelPortaliQ972S7.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni367 – 3693Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiWDNPAGV.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.

Sequencei

Sequence statusi: Complete.

Q972S7-1 [UniParc]FASTAAdd to Basket

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MYIMRSSFNF LNLLVSDKMI KKIEILNNSY VEEFIEKTAE LCNPSSIYLV    50
TSEEDKEYIR RKAIETKEEL PLKTLGHTIH FDHPLDQARA RDDTFILTDD 100
KIPFVNTKKR EDGIREVLSL LKDSMKGREM YVGFYSLGPK NSIFQHLAIQ 150
ISDSPYVIHS ENILYRLDFD DFKGNKQFLK FVHSKGELDI KKRRIMIDLK 200
EDTVYSVNTT YAGNSVGLKK LALRLTIAKA VKEGWLSEHM AIIGFEGDKG 250
THYFTASFPS GSGKTSTSMM GKLISDDLAF IREINGVARA VNPEIGVFGI 300
IQGINSKDDP IIWEVLHKPN EVIFSNVLMT EDGYVYWEGS DDKRPERGIN 350
YEGFWSNDMN KPASHPNARF TVPLTAFKNL DENYDNPDGV EIEGIIFGVR 400
DYDTLIPVVE AFSCSHGIVT IGASMESART SAVIGKGDEY EFNPMAILDF 450
MPIHLGEYLG NYLEFCKKLK KVPRIFGFNY FLKEGNRFLN SKEDKRVWIK 500
WAVKRVEGSV DVIYTPIGLV PYYEDLKTLF REMLNKEYTI EDYEKQFTLK 550
LDKYLEKNER ILKLYKEILA PKEVIAELEQ QKERILKYID KYGKRISPLD 600
LR 602
Length:602
Mass (Da):69,438
Last modified:December 1, 2001 - v1
Checksum:i83164F372DD9B567
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000023 Genomic DNA. Translation: BAB66087.1.
RefSeqiNP_376978.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAB66087; BAB66087; STK_10580.
GeneIDi1459041.
KEGGisto:ST1058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000023 Genomic DNA. Translation: BAB66087.1 .
RefSeqi NP_376978.1. NC_003106.2.

3D structure databases

ProteinModelPortali Q972S7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273063.ST1058.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB66087 ; BAB66087 ; STK_10580 .
GeneIDi 1459041.
KEGGi sto:ST1058.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi WDNPAGV.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci STOK273063:GJC7-1178-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

Entry informationi

Entry nameiPCKG_SULTO
AccessioniPrimary (citable) accession number: Q972S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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