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Q972S7

- PCKG_SULTO

UniProt

Q972S7 - PCKG_SULTO

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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn(2+) ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei89 – 891SubstrateUniRule annotation
Binding sitei213 – 2131Substrate; via amide nitrogenUniRule annotation
Metal bindingi220 – 2201ManganeseUniRule annotation
Binding sitei220 – 2201SubstrateUniRule annotation
Metal bindingi239 – 2391Manganese; via tele nitrogenUniRule annotation
Binding sitei260 – 2601SubstrateUniRule annotation
Active sitei262 – 2621UniRule annotation
Metal bindingi277 – 2771ManganeseUniRule annotation
Binding sitei369 – 3691GTPUniRule annotation
Binding sitei400 – 4001GTPUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-1178-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckGUniRule annotation
Ordered Locus Names:STK_10580
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001015: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 602602Phosphoenolpyruvate carboxykinase [GTP]PRO_0000103623Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273063.ST1058.

Structurei

3D structure databases

ProteinModelPortaliQ972S7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni367 – 3693Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiWDNPAGV.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.

Sequencei

Sequence statusi: Complete.

Q972S7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYIMRSSFNF LNLLVSDKMI KKIEILNNSY VEEFIEKTAE LCNPSSIYLV
60 70 80 90 100
TSEEDKEYIR RKAIETKEEL PLKTLGHTIH FDHPLDQARA RDDTFILTDD
110 120 130 140 150
KIPFVNTKKR EDGIREVLSL LKDSMKGREM YVGFYSLGPK NSIFQHLAIQ
160 170 180 190 200
ISDSPYVIHS ENILYRLDFD DFKGNKQFLK FVHSKGELDI KKRRIMIDLK
210 220 230 240 250
EDTVYSVNTT YAGNSVGLKK LALRLTIAKA VKEGWLSEHM AIIGFEGDKG
260 270 280 290 300
THYFTASFPS GSGKTSTSMM GKLISDDLAF IREINGVARA VNPEIGVFGI
310 320 330 340 350
IQGINSKDDP IIWEVLHKPN EVIFSNVLMT EDGYVYWEGS DDKRPERGIN
360 370 380 390 400
YEGFWSNDMN KPASHPNARF TVPLTAFKNL DENYDNPDGV EIEGIIFGVR
410 420 430 440 450
DYDTLIPVVE AFSCSHGIVT IGASMESART SAVIGKGDEY EFNPMAILDF
460 470 480 490 500
MPIHLGEYLG NYLEFCKKLK KVPRIFGFNY FLKEGNRFLN SKEDKRVWIK
510 520 530 540 550
WAVKRVEGSV DVIYTPIGLV PYYEDLKTLF REMLNKEYTI EDYEKQFTLK
560 570 580 590 600
LDKYLEKNER ILKLYKEILA PKEVIAELEQ QKERILKYID KYGKRISPLD

LR
Length:602
Mass (Da):69,438
Last modified:December 1, 2001 - v1
Checksum:i83164F372DD9B567
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAB66087.1.
RefSeqiNP_376978.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAB66087; BAB66087; STK_10580.
GeneIDi1459041.
KEGGisto:ST1058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAB66087.1 .
RefSeqi NP_376978.1. NC_003106.2.

3D structure databases

ProteinModelPortali Q972S7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273063.ST1058.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB66087 ; BAB66087 ; STK_10580 .
GeneIDi 1459041.
KEGGi sto:ST1058.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi WDNPAGV.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci STOK273063:GJC7-1178-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

Entry informationi

Entry nameiPCKG_SULTO
AccessioniPrimary (citable) accession number: Q972S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3