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Q972S7

- PCKG_SULTO

UniProt

Q972S7 - PCKG_SULTO

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

    Catalytic activityi

    GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei89 – 891SubstrateUniRule annotation
    Binding sitei213 – 2131Substrate; via amide nitrogenUniRule annotation
    Metal bindingi220 – 2201ManganeseUniRule annotation
    Binding sitei220 – 2201SubstrateUniRule annotation
    Metal bindingi239 – 2391Manganese; via tele nitrogenUniRule annotation
    Binding sitei260 – 2601SubstrateUniRule annotation
    Active sitei262 – 2621UniRule annotation
    Metal bindingi277 – 2771ManganeseUniRule annotation
    Binding sitei369 – 3691GTPUniRule annotation
    Binding sitei400 – 4001GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    GTP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSTOK273063:GJC7-1178-MONOMER.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckGUniRule annotation
    Ordered Locus Names:STK_10580
    OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
    Taxonomic identifieri273063 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001015: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 602602Phosphoenolpyruvate carboxykinase [GTP]PRO_0000103623Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273063.ST1058.

    Structurei

    3D structure databases

    ProteinModelPortaliQ972S7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni367 – 3693Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1274.
    HOGENOMiHOG000191700.
    KOiK01596.
    OMAiWDNPAGV.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00452. PEPCK_GTP.
    InterProiIPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PANTHERiPTHR11561. PTHR11561. 1 hit.
    PfamiPF00821. PEPCK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q972S7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYIMRSSFNF LNLLVSDKMI KKIEILNNSY VEEFIEKTAE LCNPSSIYLV    50
    TSEEDKEYIR RKAIETKEEL PLKTLGHTIH FDHPLDQARA RDDTFILTDD 100
    KIPFVNTKKR EDGIREVLSL LKDSMKGREM YVGFYSLGPK NSIFQHLAIQ 150
    ISDSPYVIHS ENILYRLDFD DFKGNKQFLK FVHSKGELDI KKRRIMIDLK 200
    EDTVYSVNTT YAGNSVGLKK LALRLTIAKA VKEGWLSEHM AIIGFEGDKG 250
    THYFTASFPS GSGKTSTSMM GKLISDDLAF IREINGVARA VNPEIGVFGI 300
    IQGINSKDDP IIWEVLHKPN EVIFSNVLMT EDGYVYWEGS DDKRPERGIN 350
    YEGFWSNDMN KPASHPNARF TVPLTAFKNL DENYDNPDGV EIEGIIFGVR 400
    DYDTLIPVVE AFSCSHGIVT IGASMESART SAVIGKGDEY EFNPMAILDF 450
    MPIHLGEYLG NYLEFCKKLK KVPRIFGFNY FLKEGNRFLN SKEDKRVWIK 500
    WAVKRVEGSV DVIYTPIGLV PYYEDLKTLF REMLNKEYTI EDYEKQFTLK 550
    LDKYLEKNER ILKLYKEILA PKEVIAELEQ QKERILKYID KYGKRISPLD 600
    LR 602
    Length:602
    Mass (Da):69,438
    Last modified:December 1, 2001 - v1
    Checksum:i83164F372DD9B567
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000023 Genomic DNA. Translation: BAB66087.1.
    RefSeqiNP_376978.1. NC_003106.2.

    Genome annotation databases

    EnsemblBacteriaiBAB66087; BAB66087; STK_10580.
    GeneIDi1459041.
    KEGGisto:ST1058.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000023 Genomic DNA. Translation: BAB66087.1 .
    RefSeqi NP_376978.1. NC_003106.2.

    3D structure databases

    ProteinModelPortali Q972S7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273063.ST1058.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB66087 ; BAB66087 ; STK_10580 .
    GeneIDi 1459041.
    KEGGi sto:ST1058.

    Phylogenomic databases

    eggNOGi COG1274.
    HOGENOMi HOG000191700.
    KOi K01596.
    OMAi WDNPAGV.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    BioCyci STOK273063:GJC7-1178-MONOMER.

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00452. PEPCK_GTP.
    InterProi IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    PANTHERi PTHR11561. PTHR11561. 1 hit.
    Pfami PF00821. PEPCK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

    Entry informationi

    Entry nameiPCKG_SULTO
    AccessioniPrimary (citable) accession number: Q972S7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3