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Protein

Cytochrome P450 119

Gene

cyp119

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

hemeNote: Binds 1 heme group per subunit.

Temperature dependencei

Active up to 80 degrees Celsius. Thermostable.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei76HemeBy similarity1
Binding sitei80Heme1 Publication1
Binding sitei257HemeBy similarity1
Binding sitei259Heme1 Publication1
Binding sitei315Heme1 Publication1
Metal bindingi317Iron (heme axial ligand)1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.14.13.B28. 6166.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 119 (EC:1.14.-.-)
Gene namesi
Name:cyp119
Ordered Locus Names:STK_11480
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003436141 – 367Cytochrome P450 119Add BLAST367

Interactioni

Protein-protein interaction databases

STRINGi273063.ST1148.

Structurei

Secondary structure

1367
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 11Combined sources10
Beta strandi13 – 16Combined sources4
Beta strandi18 – 23Combined sources6
Helixi26 – 34Combined sources9
Turni36 – 38Combined sources3
Turni46 – 49Combined sources4
Helixi50 – 55Combined sources6
Helixi63 – 65Combined sources3
Helixi68 – 70Combined sources3
Helixi75 – 81Combined sources7
Helixi84 – 87Combined sources4
Helixi89 – 91Combined sources3
Helixi94 – 106Combined sources13
Beta strandi110 – 113Combined sources4
Helixi114 – 117Combined sources4
Turni118 – 120Combined sources3
Helixi121 – 131Combined sources11
Helixi137 – 148Combined sources12
Turni149 – 152Combined sources4
Helixi156 – 158Combined sources3
Helixi162 – 178Combined sources17
Turni179 – 181Combined sources3
Helixi186 – 191Combined sources6
Beta strandi193 – 195Combined sources3
Helixi197 – 209Combined sources13
Turni210 – 212Combined sources3
Helixi213 – 228Combined sources16
Helixi232 – 238Combined sources7
Helixi241 – 250Combined sources10
Beta strandi257 – 263Combined sources7
Beta strandi265 – 267Combined sources3
Beta strandi270 – 272Combined sources3
Beta strandi277 – 280Combined sources4
Helixi282 – 285Combined sources4
Turni289 – 291Combined sources3
Beta strandi292 – 294Combined sources3
Helixi320 – 337Combined sources18
Beta strandi338 – 348Combined sources11
Beta strandi352 – 354Combined sources3
Beta strandi356 – 366Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UE8X-ray3.00A1-367[»]
3B4XX-ray1.94A1-367[»]
ProteinModelPortaliQ972I2.
SMRiQ972I2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ972I2.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiarCOG02814. Archaea.
COG2124. LUCA.
HOGENOMiHOG000243678.
OMAiVQMTART.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q972I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYDWFKQMRK ESPVYYDGKV WNLFKYEDCK MVLNDHKRFS SNLTGYNDKL
60 70 80 90 100
EMLRSGKVFF DIPTRYTMLT SDPPLHDELR NLTADAFNPS NLPVDFVREV
110 120 130 140 150
TVKLLSELDE EFDVIESFAI PLPILVISKM LGINPDVKKV KDWSDLVALR
160 170 180 190 200
LGRADEIFSI GRKYLELISF SKKELDSRKG KEIVDLTGKI ANSNLSELEK
210 220 230 240 250
EGYFILLMIA GNETTTNLIG NAIEDFTLYN SWDYVREKGA LKAVEEALRF
260 270 280 290 300
SPPVMRTIRV TKEKVKIRDQ VIDEGELVRV WIASANRDEE VFKDPDSFIP
310 320 330 340 350
DRTPNPHLSF GSGIHLCLGA PLARLEARIA LEEFAKKFRV KEIVKKEKID
360
NEVLNGYRKL VVRVERA
Length:367
Mass (Da):42,324
Last modified:December 1, 2001 - v1
Checksum:iE001CB1FF8BA8E8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54472.1.
RefSeqiWP_010979165.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAK54472; BAK54472; STK_11480.
GeneIDi1459138.
KEGGisto:STK_11480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54472.1.
RefSeqiWP_010979165.1. NC_003106.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UE8X-ray3.00A1-367[»]
3B4XX-ray1.94A1-367[»]
ProteinModelPortaliQ972I2.
SMRiQ972I2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273063.ST1148.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAK54472; BAK54472; STK_11480.
GeneIDi1459138.
KEGGisto:STK_11480.

Phylogenomic databases

eggNOGiarCOG02814. Archaea.
COG2124. LUCA.
HOGENOMiHOG000243678.
OMAiVQMTART.

Enzyme and pathway databases

BRENDAi1.14.13.B28. 6166.

Miscellaneous databases

EvolutionaryTraceiQ972I2.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP119_SULTO
AccessioniPrimary (citable) accession number: Q972I2
Secondary accession number(s): F9VNW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.