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Protein

Cytochrome P450 119

Gene

cyp119

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

hemeNote: Binds 1 heme group per subunit.

Temperature dependencei

Active up to 80 degrees Celsius. Thermostable.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei76 – 761HemeBy similarity
Binding sitei80 – 801Heme1 Publication
Binding sitei257 – 2571HemeBy similarity
Binding sitei259 – 2591Heme1 Publication
Binding sitei315 – 3151Heme1 Publication
Metal bindingi317 – 3171Iron (heme axial ligand)

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-1275-MONOMER.
BRENDAi1.14.13.B28. 6166.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 119 (EC:1.14.-.-)
Gene namesi
Name:cyp119
Ordered Locus Names:STK_11480
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367Cytochrome P450 119PRO_0000343614Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273063.ST1148.

Structurei

Secondary structure

1
367
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 1110Combined sources
Beta strandi13 – 164Combined sources
Beta strandi18 – 236Combined sources
Helixi26 – 349Combined sources
Turni36 – 383Combined sources
Turni46 – 494Combined sources
Helixi50 – 556Combined sources
Helixi63 – 653Combined sources
Helixi68 – 703Combined sources
Helixi75 – 817Combined sources
Helixi84 – 874Combined sources
Helixi89 – 913Combined sources
Helixi94 – 10613Combined sources
Beta strandi110 – 1134Combined sources
Helixi114 – 1174Combined sources
Turni118 – 1203Combined sources
Helixi121 – 13111Combined sources
Helixi137 – 14812Combined sources
Turni149 – 1524Combined sources
Helixi156 – 1583Combined sources
Helixi162 – 17817Combined sources
Turni179 – 1813Combined sources
Helixi186 – 1916Combined sources
Beta strandi193 – 1953Combined sources
Helixi197 – 20913Combined sources
Turni210 – 2123Combined sources
Helixi213 – 22816Combined sources
Helixi232 – 2387Combined sources
Helixi241 – 25010Combined sources
Beta strandi257 – 2637Combined sources
Beta strandi265 – 2673Combined sources
Beta strandi270 – 2723Combined sources
Beta strandi277 – 2804Combined sources
Helixi282 – 2854Combined sources
Turni289 – 2913Combined sources
Beta strandi292 – 2943Combined sources
Helixi320 – 33718Combined sources
Beta strandi338 – 34811Combined sources
Beta strandi352 – 3543Combined sources
Beta strandi356 – 36611Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UE8X-ray3.00A1-367[»]
3B4XX-ray1.94A1-367[»]
ProteinModelPortaliQ972I2.
SMRiQ972I2. Positions 1-366.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ972I2.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiarCOG02814. Archaea.
COG2124. LUCA.
HOGENOMiHOG000243678.
OMAiVQMTART.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q972I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYDWFKQMRK ESPVYYDGKV WNLFKYEDCK MVLNDHKRFS SNLTGYNDKL
60 70 80 90 100
EMLRSGKVFF DIPTRYTMLT SDPPLHDELR NLTADAFNPS NLPVDFVREV
110 120 130 140 150
TVKLLSELDE EFDVIESFAI PLPILVISKM LGINPDVKKV KDWSDLVALR
160 170 180 190 200
LGRADEIFSI GRKYLELISF SKKELDSRKG KEIVDLTGKI ANSNLSELEK
210 220 230 240 250
EGYFILLMIA GNETTTNLIG NAIEDFTLYN SWDYVREKGA LKAVEEALRF
260 270 280 290 300
SPPVMRTIRV TKEKVKIRDQ VIDEGELVRV WIASANRDEE VFKDPDSFIP
310 320 330 340 350
DRTPNPHLSF GSGIHLCLGA PLARLEARIA LEEFAKKFRV KEIVKKEKID
360
NEVLNGYRKL VVRVERA
Length:367
Mass (Da):42,324
Last modified:December 1, 2001 - v1
Checksum:iE001CB1FF8BA8E8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54472.1.
RefSeqiWP_010979165.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAK54472; BAK54472; STK_11480.
GeneIDi1459138.
KEGGisto:STK_11480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54472.1.
RefSeqiWP_010979165.1. NC_003106.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UE8X-ray3.00A1-367[»]
3B4XX-ray1.94A1-367[»]
ProteinModelPortaliQ972I2.
SMRiQ972I2. Positions 1-366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273063.ST1148.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAK54472; BAK54472; STK_11480.
GeneIDi1459138.
KEGGisto:STK_11480.

Phylogenomic databases

eggNOGiarCOG02814. Archaea.
COG2124. LUCA.
HOGENOMiHOG000243678.
OMAiVQMTART.

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-1275-MONOMER.
BRENDAi1.14.13.B28. 6166.

Miscellaneous databases

EvolutionaryTraceiQ972I2.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP119_SULTO
AccessioniPrimary (citable) accession number: Q972I2
Secondary accession number(s): F9VNW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.