Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-aspartate oxidase

Gene

nadB

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of L-aspartate to iminoaspartate.

Catalytic activityi

L-aspartate + O2 = iminosuccinate + H2O2.

Cofactori

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes iminoaspartate from L-aspartate (oxidase route).
Proteins known to be involved in this subpathway in this organism are:
  1. L-aspartate oxidase (nadB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes iminoaspartate from L-aspartate (oxidase route), the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei212By similarity1
Active sitei230By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi3 – 17FADSequence analysisAdd BLAST15

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.4.3.16. 6166.
UniPathwayiUPA00253; UER00326.

Names & Taxonomyi

Protein namesi
Recommended name:
L-aspartate oxidase (EC:1.4.3.16)
Short name:
LASPO
Alternative name(s):
Quinolinate synthase B
Gene namesi
Name:nadB
Ordered Locus Names:STK_11960
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844121 – 472L-aspartate oxidaseAdd BLAST472

Interactioni

Protein-protein interaction databases

STRINGi273063.ST1196.

Structurei

Secondary structure

1472
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 5Combined sources4
Helixi9 – 20Combined sources12
Beta strandi25 – 28Combined sources4
Helixi37 – 39Combined sources3
Helixi54 – 65Combined sources12
Helixi71 – 90Combined sources20
Beta strandi113 – 115Combined sources3
Helixi117 – 131Combined sources15
Beta strandi141 – 147Combined sources7
Beta strandi150 – 156Combined sources7
Turni157 – 159Combined sources3
Beta strandi160 – 162Combined sources3
Beta strandi166 – 170Combined sources5
Helixi176 – 178Combined sources3
Beta strandi179 – 184Combined sources6
Helixi191 – 198Combined sources8
Beta strandi209 – 216Combined sources8
Helixi218 – 220Combined sources3
Helixi228 – 231Combined sources4
Beta strandi235 – 238Combined sources4
Helixi244 – 247Combined sources4
Helixi252 – 254Combined sources3
Helixi257 – 269Combined sources13
Beta strandi274 – 277Combined sources4
Helixi284 – 287Combined sources4
Helixi289 – 297Combined sources9
Beta strandi309 – 316Combined sources8
Beta strandi318 – 320Combined sources3
Beta strandi328 – 330Combined sources3
Beta strandi332 – 334Combined sources3
Helixi336 – 338Combined sources3
Beta strandi342 – 344Combined sources3
Helixi352 – 363Combined sources12
Helixi364 – 366Combined sources3
Turni367 – 369Combined sources3
Beta strandi380 – 385Combined sources6
Helixi395 – 405Combined sources11
Beta strandi406 – 410Combined sources5
Helixi412 – 422Combined sources11
Helixi428 – 442Combined sources15
Helixi460 – 462Combined sources3
Beta strandi464 – 470Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E5VX-ray2.09A/B1-472[»]
ProteinModelPortaliQ972D2.
SMRiQ972D2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ972D2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00572. Archaea.
COG0029. LUCA.
HOGENOMiHOG000160476.
KOiK00278.
OMAiWIGVERT.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.

Sequencei

Sequence statusi: Complete.

Q972D2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYIIGSGIA GLSAGVALRR AGKKVTLISK RIDGGSTPIA KGGVAASVGS
60 70 80 90 100
DDSPELHAQD TIRVGDGLCD VKTVNYVTSE AKNVIETFES WGFEFEEDLR
110 120 130 140 150
LEGGHTKRRV LHRTDETGRE IFNFLLKLAR EEGIPIIEDR LVEIRVKDGK
160 170 180 190 200
VTGFVTEKRG LVEDVDKLVL ATGGYSYLYE YSSTQSTNIG DGMAIAFKAG
210 220 230 240 250
TILADMEFVQ FHPTVTSLDG EVFLLTETLR GEGAQIINEN GERFLFNYDK
260 270 280 290 300
RGELAPRDIL SRAIYIEMLK GHKVFIDLSK IEDFERKFPV VAKYLARHGH
310 320 330 340 350
NYKVKIPIFP AAHFVDGGIR VNIRGESNIV NLYAIGEVSD SGLHGANRLA
360 370 380 390 400
SNSLLEGLVF GINLPRYVDS SWEGISTDDG IVHSVRISGN KTLSLKEIRR
410 420 430 440 450
INWENVGIIR NEEKLVKAIN TYSSSTQNEA IISYLTALAA EIRKESRGNH
460 470
FREDYPYKDP NWEKRIYFKL VV
Length:472
Mass (Da):52,582
Last modified:December 1, 2001 - v1
Checksum:i9B31FAC6FE79801F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54476.1.
RefSeqiWP_010979215.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAK54476; BAK54476; STK_11960.
GeneIDi1459193.
KEGGisto:STK_11960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54476.1.
RefSeqiWP_010979215.1. NC_003106.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E5VX-ray2.09A/B1-472[»]
ProteinModelPortaliQ972D2.
SMRiQ972D2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273063.ST1196.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAK54476; BAK54476; STK_11960.
GeneIDi1459193.
KEGGisto:STK_11960.

Phylogenomic databases

eggNOGiarCOG00572. Archaea.
COG0029. LUCA.
HOGENOMiHOG000160476.
KOiK00278.
OMAiWIGVERT.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00326.
BRENDAi1.4.3.16. 6166.

Miscellaneous databases

EvolutionaryTraceiQ972D2.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADB_SULTO
AccessioniPrimary (citable) accession number: Q972D2
Secondary accession number(s): F9VNW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.