Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-aspartate oxidase

Gene

nadB

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of L-aspartate to iminoaspartate.

Catalytic activityi

L-aspartate + O2 = iminosuccinate + H2O2.

Cofactori

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes iminoaspartate from L-aspartate (oxidase route).
Proteins known to be involved in this subpathway in this organism are:
  1. L-aspartate oxidase (nadB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes iminoaspartate from L-aspartate (oxidase route), the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei212 – 2121By similarity
Active sitei230 – 2301By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi3 – 1715FADSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-1329-MONOMER.
BRENDAi1.4.3.16. 6166.
UniPathwayiUPA00253; UER00326.

Names & Taxonomyi

Protein namesi
Recommended name:
L-aspartate oxidase (EC:1.4.3.16)
Short name:
LASPO
Alternative name(s):
Quinolinate synthase B
Gene namesi
Name:nadB
Ordered Locus Names:STK_11960
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472L-aspartate oxidasePRO_0000184412Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273063.ST1196.

Structurei

Secondary structure

1
472
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 54Combined sources
Helixi9 – 2012Combined sources
Beta strandi25 – 284Combined sources
Helixi37 – 393Combined sources
Helixi54 – 6512Combined sources
Helixi71 – 9020Combined sources
Beta strandi113 – 1153Combined sources
Helixi117 – 13115Combined sources
Beta strandi141 – 1477Combined sources
Beta strandi150 – 1567Combined sources
Turni157 – 1593Combined sources
Beta strandi160 – 1623Combined sources
Beta strandi166 – 1705Combined sources
Helixi176 – 1783Combined sources
Beta strandi179 – 1846Combined sources
Helixi191 – 1988Combined sources
Beta strandi209 – 2168Combined sources
Helixi218 – 2203Combined sources
Helixi228 – 2314Combined sources
Beta strandi235 – 2384Combined sources
Helixi244 – 2474Combined sources
Helixi252 – 2543Combined sources
Helixi257 – 26913Combined sources
Beta strandi274 – 2774Combined sources
Helixi284 – 2874Combined sources
Helixi289 – 2979Combined sources
Beta strandi309 – 3168Combined sources
Beta strandi318 – 3203Combined sources
Beta strandi328 – 3303Combined sources
Beta strandi332 – 3343Combined sources
Helixi336 – 3383Combined sources
Beta strandi342 – 3443Combined sources
Helixi352 – 36312Combined sources
Helixi364 – 3663Combined sources
Turni367 – 3693Combined sources
Beta strandi380 – 3856Combined sources
Helixi395 – 40511Combined sources
Beta strandi406 – 4105Combined sources
Helixi412 – 42211Combined sources
Helixi428 – 44215Combined sources
Helixi460 – 4623Combined sources
Beta strandi464 – 4707Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E5VX-ray2.09A/B1-472[»]
ProteinModelPortaliQ972D2.
SMRiQ972D2. Positions 1-472.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ972D2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00572. Archaea.
COG0029. LUCA.
HOGENOMiHOG000160476.
KOiK00278.
OMAiGANLYWI.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.

Sequencei

Sequence statusi: Complete.

Q972D2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYIIGSGIA GLSAGVALRR AGKKVTLISK RIDGGSTPIA KGGVAASVGS
60 70 80 90 100
DDSPELHAQD TIRVGDGLCD VKTVNYVTSE AKNVIETFES WGFEFEEDLR
110 120 130 140 150
LEGGHTKRRV LHRTDETGRE IFNFLLKLAR EEGIPIIEDR LVEIRVKDGK
160 170 180 190 200
VTGFVTEKRG LVEDVDKLVL ATGGYSYLYE YSSTQSTNIG DGMAIAFKAG
210 220 230 240 250
TILADMEFVQ FHPTVTSLDG EVFLLTETLR GEGAQIINEN GERFLFNYDK
260 270 280 290 300
RGELAPRDIL SRAIYIEMLK GHKVFIDLSK IEDFERKFPV VAKYLARHGH
310 320 330 340 350
NYKVKIPIFP AAHFVDGGIR VNIRGESNIV NLYAIGEVSD SGLHGANRLA
360 370 380 390 400
SNSLLEGLVF GINLPRYVDS SWEGISTDDG IVHSVRISGN KTLSLKEIRR
410 420 430 440 450
INWENVGIIR NEEKLVKAIN TYSSSTQNEA IISYLTALAA EIRKESRGNH
460 470
FREDYPYKDP NWEKRIYFKL VV
Length:472
Mass (Da):52,582
Last modified:December 1, 2001 - v1
Checksum:i9B31FAC6FE79801F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54476.1.
RefSeqiWP_010979215.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAK54476; BAK54476; STK_11960.
GeneIDi1459193.
KEGGisto:STK_11960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54476.1.
RefSeqiWP_010979215.1. NC_003106.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E5VX-ray2.09A/B1-472[»]
ProteinModelPortaliQ972D2.
SMRiQ972D2. Positions 1-472.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273063.ST1196.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAK54476; BAK54476; STK_11960.
GeneIDi1459193.
KEGGisto:STK_11960.

Phylogenomic databases

eggNOGiarCOG00572. Archaea.
COG0029. LUCA.
HOGENOMiHOG000160476.
KOiK00278.
OMAiGANLYWI.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00326.
BioCyciSTOK273063:GJC7-1329-MONOMER.
BRENDAi1.4.3.16. 6166.

Miscellaneous databases

EvolutionaryTraceiQ972D2.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

Entry informationi

Entry nameiNADB_SULTO
AccessioniPrimary (citable) accession number: Q972D2
Secondary accession number(s): F9VNW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: December 1, 2001
Last modified: December 9, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.