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Q972C0

- GCSPB_SULTO

UniProt

Q972C0 - GCSPB_SULTO

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, STK_12080
Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-1342-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:STK_12080
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001015: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_0000167032Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei274 – 2741N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi273063.ST1208.

Structurei

3D structure databases

ProteinModelPortaliQ972C0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q972C0-1 [UniParc]FASTAAdd to Basket

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MSWHQAVWNE PLIFEYKGKG RIGFKIPEEE ELKKEISINI PEKLRRKEID    50
LPELSELEVI RHFIRLSQMS FGVDNGMVPL GSCTMKYNPK IEEEAELLTQ 100
NLHPLQDDST VQGILEVLYY MQKWLAEITG MDLCSLQVPA GAAGELAGVL 150
MIKKYHETKG RGNRDEMLVA DTAHGTNPAS ASMENFKVIY IKSNSEGLVD 200
VDILKEIVSE RTAGFMLTNP NTLGLFEENI LDIAKYIHSV DAKLYYDGAN 250
LNGILGVVRP GDMGFDIVHL NLHKTFAVPH GGGGPGAGAI CAKGEMVNFL 300
PYPLVEKKDG KYSLSYIPKY SIGKIATFYG NVGNVVRAYT YILGLGAEGI 350
SMIGKMSTLA TNYLISQLKN VRGLELIAPY RPRKHEVVFS AKTLAKETGV 400
TANDVAKALL DRGFYAPTIY FPPNVEEALM IEPTETEPKE VLDSFAIAIK 450
EIINTAYSNP KEILDTPKNT SVKRLDQVIA NHPSSVTPTY RVKRLREEGK 500
IGSLK 505
Length:505
Mass (Da):55,985
Last modified:December 1, 2001 - v1
Checksum:iCA498DA852400DE9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000023 Genomic DNA. Translation: BAK54485.1.
RefSeqiNP_377140.1. NC_003106.2.
WP_010979227.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAK54485; BAK54485; STK_12080.
GeneIDi1459206.
KEGGisto:ST1208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000023 Genomic DNA. Translation: BAK54485.1 .
RefSeqi NP_377140.1. NC_003106.2.
WP_010979227.1. NC_003106.2.

3D structure databases

ProteinModelPortali Q972C0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273063.ST1208.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAK54485 ; BAK54485 ; STK_12080 .
GeneIDi 1459206.
KEGGi sto:ST1208.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.

Enzyme and pathway databases

BioCyci STOK273063:GJC7-1342-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

Entry informationi

Entry nameiGCSPB_SULTO
AccessioniPrimary (citable) accession number: Q972C0
Secondary accession number(s): F9VNX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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