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Q972A8 (OGG1_SULTO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable N-glycosylase/DNA lyase

Including the following 2 domains:

  1. 8-oxoguanine DNA glycosylase
    EC=3.2.2.-
  2. DNA-(apurinic or apyrimidinic site) lyase
    Short name=AP lyase
    EC=4.2.99.18
Gene names
Name:ogg
Ordered Locus Names:STK_12190
OrganismSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) [Complete proteome] [HAMAP]
Taxonomic identifier273063 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus ›

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity. HAMAP-Rule MF_00241

Catalytic activity

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. HAMAP-Rule MF_00241

Sequence similarities

Belongs to the type-2 OGG1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 204204Probable N-glycosylase/DNA lyase HAMAP-Rule MF_00241
PRO_0000159567

Sites

Active site1281 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q972A8 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 42A27A11B7CE5FCF

FASTA20423,886
        10         20         30         40         50         60 
MLRELVKNKK LRARVLERAE EFKLNNRAEE NVWFRELILC ILTSNSSFIS AYKALNYIMD 

        70         80         90        100        110        120 
EIFSLSEDQM SKRLRLAGYR FYNLKAKYIA NARKLYGNLK TKIKPIADYS QEEARQYIIN 

       130        140        150        160        170        180 
NIDGLGLKES SHFLRNVGYF DLAIIDRHVL HFLNEIGTSN LKIKNKKDYY LAESILKSIS 

       190        200 
INLGIQVGLL DLYIFFKQTN TIVK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000023 Genomic DNA. Translation: BAB66261.1.
RefSeqNP_377152.1. NC_003106.2.

3D structure databases

ProteinModelPortalQ972A8.
ModBaseSearch...

Protein-protein interaction databases

STRING273063.ST1219.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB66261; BAB66261; STK_12190.
GeneID1459218.
KEGGsto:ST1219.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1059.
HOGENOMHOG000224507.
KOK03653.
OMAIIDRHIL.
ProtClustDBPRK01229.

Family and domain databases

Gene3D1.10.340.30. 1 hit.
HAMAPMF_00241. Ogg.
InterProIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
[Graphical view]
PIRSFPIRSF005954. Thrmst_ogg. 1 hit.
SUPFAMSSF48150. DNA_glycsylse. 1 hit.
ProtoNetSearch...

Entry information

Entry nameOGG1_SULTO
AccessionPrimary (citable) accession number: Q972A8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: December 1, 2001
Last modified: May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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