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Protein

Riboflavin kinase

Gene

ribK

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).UniRule annotation

Catalytic activityi

CTP + riboflavin = CDP + FMN.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathway: FMN biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FMN from riboflavin (CTP route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Riboflavin kinase (ribK)
This subpathway is part of the pathway FMN biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FMN from riboflavin (CTP route), the pathway FMN biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi44 – 441MagnesiumUniRule annotation
Metal bindingi46 – 461MagnesiumUniRule annotation
Binding sitei103 – 1031FMNUniRule annotation
Binding sitei111 – 1111FMNUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 206CDPUniRule annotation
Nucleotide bindingi116 – 1194CDPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

Flavoprotein, FMN, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-1415-MONOMER.
UniPathwayiUPA00276; UER00929.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin kinaseUniRule annotation (EC:2.7.1.161UniRule annotation)
Short name:
RFKUniRule annotation
Alternative name(s):
CTP-dependent riboflavin kinaseUniRule annotation
CTP:riboflavin 5'-phosphotransferaseUniRule annotation
FlavokinaseUniRule annotation
Gene namesi
Name:ribKUniRule annotation
Ordered Locus Names:STK_12800
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001015 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 136136Riboflavin kinasePRO_0000322080Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273063.ST1280.

Structurei

3D structure databases

ProteinModelPortaliQ971U9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal riboflavin kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1339.
HOGENOMiHOG000015512.
KOiK07732.
OMAiPYEGTLN.

Family and domain databases

Gene3Di2.40.30.30. 1 hit.
HAMAPiMF_01285. Riboflavin_kinase.
InterProiIPR023470. Riboflavin_kinase_archaeal.
IPR015865. Riboflavin_kinase_bac/euk.
IPR023602. Riboflavin_kinase_CTP-dep.
IPR023465. Riboflavin_kinase_domain.
[Graphical view]
PfamiPF01982. CTP-dep_RFKase. 1 hit.
[Graphical view]
SUPFAMiSSF82114. SSF82114. 1 hit.

Sequencei

Sequence statusi: Complete.

Q971U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTKILHIKG KVTAGLGEGR IFLSIPYYIE SFKKYLGFEP YAGTLNIVIY
60 70 80 90 100
DRISLENRLI LDLAKGIIIP EHKEPNRVLG SVKAFPSSIN SISPAAIVIP
110 120 130
ARTTHPKSVI EIISPYYLRE KLSLKDGDEV EIEVYL
Length:136
Mass (Da):15,284
Last modified:December 1, 2001 - v1
Checksum:i0FFCB18C7770D092
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAB66321.1.
RefSeqiNP_377212.1. NC_003106.2.
WP_010979299.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAB66321; BAB66321; STK_12800.
GeneIDi1459279.
KEGGisto:ST1280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAB66321.1.
RefSeqiNP_377212.1. NC_003106.2.
WP_010979299.1. NC_003106.2.

3D structure databases

ProteinModelPortaliQ971U9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273063.ST1280.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB66321; BAB66321; STK_12800.
GeneIDi1459279.
KEGGisto:ST1280.

Phylogenomic databases

eggNOGiCOG1339.
HOGENOMiHOG000015512.
KOiK07732.
OMAiPYEGTLN.

Enzyme and pathway databases

UniPathwayiUPA00276; UER00929.
BioCyciSTOK273063:GJC7-1415-MONOMER.

Family and domain databases

Gene3Di2.40.30.30. 1 hit.
HAMAPiMF_01285. Riboflavin_kinase.
InterProiIPR023470. Riboflavin_kinase_archaeal.
IPR015865. Riboflavin_kinase_bac/euk.
IPR023602. Riboflavin_kinase_CTP-dep.
IPR023465. Riboflavin_kinase_domain.
[Graphical view]
PfamiPF01982. CTP-dep_RFKase. 1 hit.
[Graphical view]
SUPFAMiSSF82114. SSF82114. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

Entry informationi

Entry nameiRIFK_SULTO
AccessioniPrimary (citable) accession number: Q971U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 1, 2001
Last modified: May 27, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.