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Protein

Riboflavin kinase

Gene

ribK

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).UniRule annotation

Catalytic activityi

CTP + riboflavin = CDP + FMN.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi44 – 441MagnesiumUniRule annotation
Metal bindingi46 – 461MagnesiumUniRule annotation
Binding sitei103 – 1031FMNUniRule annotation
Binding sitei111 – 1111FMNUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 206CDPUniRule annotation
Nucleotide bindingi116 – 1194CDPUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. nucleotide binding Source: UniProtKB-HAMAP
  3. riboflavin kinase activity Source: InterPro

GO - Biological processi

  1. FMN biosynthetic process Source: UniProtKB-HAMAP
  2. riboflavin biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

Flavoprotein, FMN, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-1415-MONOMER.
UniPathwayiUPA00276; UER00929.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin kinaseUniRule annotation (EC:2.7.1.161UniRule annotation)
Short name:
RFKUniRule annotation
Alternative name(s):
CTP-dependent riboflavin kinaseUniRule annotation
CTP:riboflavin 5'-phosphotransferaseUniRule annotation
FlavokinaseUniRule annotation
Gene namesi
Name:ribKUniRule annotation
Ordered Locus Names:STK_12800
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001015 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 136136Riboflavin kinasePRO_0000322080Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273063.ST1280.

Structurei

3D structure databases

ProteinModelPortaliQ971U9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal riboflavin kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1339.
HOGENOMiHOG000015512.
KOiK07732.
OMAiPYEGTLN.

Family and domain databases

Gene3Di2.40.30.30. 1 hit.
HAMAPiMF_01285. Riboflavin_kinase.
InterProiIPR023470. Riboflavin_kinase_archaeal.
IPR015865. Riboflavin_kinase_bac/euk.
IPR023602. Riboflavin_kinase_CTP-dep.
IPR023465. Riboflavin_kinase_domain.
[Graphical view]
PfamiPF01982. CTP-dep_RFKase. 1 hit.
[Graphical view]
SUPFAMiSSF82114. SSF82114. 1 hit.

Sequencei

Sequence statusi: Complete.

Q971U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTKILHIKG KVTAGLGEGR IFLSIPYYIE SFKKYLGFEP YAGTLNIVIY
60 70 80 90 100
DRISLENRLI LDLAKGIIIP EHKEPNRVLG SVKAFPSSIN SISPAAIVIP
110 120 130
ARTTHPKSVI EIISPYYLRE KLSLKDGDEV EIEVYL
Length:136
Mass (Da):15,284
Last modified:November 30, 2001 - v1
Checksum:i0FFCB18C7770D092
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAB66321.1.
RefSeqiNP_377212.1. NC_003106.2.
WP_010979299.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAB66321; BAB66321; STK_12800.
GeneIDi1459279.
KEGGisto:ST1280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAB66321.1.
RefSeqiNP_377212.1. NC_003106.2.
WP_010979299.1. NC_003106.2.

3D structure databases

ProteinModelPortaliQ971U9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273063.ST1280.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB66321; BAB66321; STK_12800.
GeneIDi1459279.
KEGGisto:ST1280.

Phylogenomic databases

eggNOGiCOG1339.
HOGENOMiHOG000015512.
KOiK07732.
OMAiPYEGTLN.

Enzyme and pathway databases

UniPathwayiUPA00276; UER00929.
BioCyciSTOK273063:GJC7-1415-MONOMER.

Family and domain databases

Gene3Di2.40.30.30. 1 hit.
HAMAPiMF_01285. Riboflavin_kinase.
InterProiIPR023470. Riboflavin_kinase_archaeal.
IPR015865. Riboflavin_kinase_bac/euk.
IPR023602. Riboflavin_kinase_CTP-dep.
IPR023465. Riboflavin_kinase_domain.
[Graphical view]
PfamiPF01982. CTP-dep_RFKase. 1 hit.
[Graphical view]
SUPFAMiSSF82114. SSF82114. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

Entry informationi

Entry nameiRIFK_SULTO
AccessioniPrimary (citable) accession number: Q971U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 25, 2008
Last sequence update: November 30, 2001
Last modified: March 31, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.