ID   G3P_SULTO               Reviewed;         343 AA.
AC   Q971K2;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   16-JUN-2009, entry version 55.
DE   RecName: Full=Glyceraldehyde-3-phosphate dehydrogenase;
DE            Short=GAPDH;
DE            EC=1.2.1.59;
DE   AltName: Full=NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase;
GN   Name=gap; OrderedLocusNames=ST1356;
OS   Sulfolobus tokodaii.
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=111955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16993 / JCM 10545 / NBRC 100140 / 7;
RX   MEDLINE=21456156; PubMed=11572479; DOI=10.1093/dnares/8.4.123;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Jin-no K., Takahashi M.,
RA   Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S.,
RA   Nagai Y., Nishijima K., Otsuka R., Nakazawa H., Takamiya M., Kato Y.,
RA   Yoshizawa T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Masuda S., Yanagii M., Nishimura M., Yamagishi A., Oshima T.,
RA   Kikuchi H.;
RT   "Complete genome sequence of an aerobic thermoacidophilic
RT   Crenarchaeon, Sulfolobus tokodaii strain7.";
RL   DNA Res. 8:123-140(2001).
CC   -!- CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate + phosphate +
CC       NAD(P)(+) = 3-phospho-D-glyceroyl phosphate + NAD(P)H.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC       glyceraldehyde 3-phosphate: step 1/5.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the glyceraldehyde-3-phosphate
CC       dehydrogenase family.
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DR   EMBL; BA000023; BAB66418.1; -; Genomic_DNA.
DR   RefSeq; NP_377309.1; -.
DR   HSSP; P39460; 1B7G.
DR   GeneID; 1459378; -.
DR   GenomeReviews; BA000023_GR; ST1356.
DR   KEGG; sto:ST1356; -.
DR   NMPDR; fig|273063.1.peg.1477; -.
DR   HOGENOM; Q971K2; -.
DR   OMA; Q971K2; AIFQGGE.
DR   BRENDA; 1.2.1.59; 261167.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043891; F:glyceraldehyde-3-phosphate dehydrogenase (N...; IEA:EC.
DR   GO; GO:0004365; F:glyceraldehyde-3-phosphate dehydrogenase (p...; IEA:HAMAP.
DR   GO; GO:0051287; F:NAD or NADH binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0006096; P:glycolysis; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00559; -; 1.
DR   InterPro; IPR000173; GlycerAld_3-P_DH.
DR   InterPro; IPR006436; Glyceraldehyde-3-P_DH_2_arc.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF02800; Gp_dh_C; 1.
DR   Pfam; PF00044; Gp_dh_N; 1.
DR   PIRSF; PIRSF000149; GAP_DH; 1.
DR   ProDom; PD007761; GAPDH_like; 1.
DR   TIGRFAMs; TIGR01546; GAPDH-II_archae; 1.
DR   PROSITE; PS00071; GAPDH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Glycolysis; NAD; NADP; Oxidoreductase.
FT   CHAIN         1    343       Glyceraldehyde-3-phosphate dehydrogenase.
FT                                /FTId=PRO_0000145736.
FT   NP_BIND      13     14       NAD (By similarity).
FT   REGION      140    142       Glyceraldehyde 3-phosphate binding (By
FT                                similarity).
FT   REGION      195    196       Glyceraldehyde 3-phosphate binding (By
FT                                similarity).
FT   ACT_SITE    141    141       Nucleophile (By similarity).
FT   BINDING     111    111       NAD; via amide nitrogen (By similarity).
FT   BINDING     169    169       NAD (By similarity).
FT   BINDING     303    303       NAD; via carbonyl oxygen (By similarity).
SQ   SEQUENCE   343 AA;  37515 MW;  F5620C2D7A673303 CRC64;
     MEKVKVAVNG YGTIGKRVAD AIRLQPDMEL IGVGKTSPNY EAIIADKKGI KIYTVKDNIG
     KFEKSGIRVA GTIEDMVKEA DIVVDTTPNG VGATYKPLYQ SLGKNALFQG GEKADVADIS
     FSALCNYDEA KGKKYIRVVS CNTTGMLRII CTMNKISKVE KVRATIVRRA ADPKEVKRGP
     INSIVPDPAS VPSHHAKDVL TVIKGIDIVT MAVIAPTTLM HLHTMVLTVK DKVNRDDIIN
     TFLNTPRIIL VNSSRTTVSS TAEIIEVSRD MGRVRYDIPE VVVFEDSIYT NGNEVFLMYG
     VHQESIVVPE NIDAIRASLG LMGKEESIKV TNDTLGIMKG YLL
//