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Q971D0 (SYE_SULTO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate--tRNA ligase

EC=6.1.1.17
Alternative name(s):
Glutamyl-tRNA synthetase
Short name=GluRS
Gene names
Name:gltX
Ordered Locus Names:STK_14230
OrganismSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) [Complete proteome] [HAMAP]
Taxonomic identifier273063 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length566 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity. HAMAP-Rule MF_00022

Catalytic activity

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). HAMAP-Rule MF_00022

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00022.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglutamyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glutamate-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 566566Glutamate--tRNA ligase HAMAP-Rule MF_00022
PRO_0000119732

Regions

Motif105 – 11511"HIGH" region HAMAP-Rule MF_00022

Sequences

Sequence LengthMass (Da)Tools
Q971D0 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 5741806D8D2482CF

FASTA56665,517
        10         20         30         40         50         60 
MEEIEELIYK YALQNAYKHG GKAQDKAVVS KIFVERPDLR SRAKEISEIA KKIVEKVNSM 

        70         80         90        100        110        120 
SIQDQERELK EKYPDLLEEK KKEEPEKKTL PPIKVEGKFV TRFAPNPDGP IHLGNARAAI 

       130        140        150        160        170        180 
ISYKYAEMYK GEFILRFDDT DPKVKKPIKE AYDWIRKDLK WLGIKWDKEV KASERLEFYY 

       190        200        210        220        230        240 
SMAKELISKG FAYVDTCSEE EFKKMRDASK PCPNRLKSAE DNLYLFEKML NGEFKEGEAV 

       250        260        270        280        290        300 
VRIKTDLSLP DPSQRDWVLL RIIDVKKNPH PITGDKYWIW PTYNFASALD DHDLGITHIF 

       310        320        330        340        350        360 
RGKEHEVNAE KQKWIYNYMG WKYPYVEEFG RLRLEGFMMS KSKIRTVLEK GVSIDDPRLP 

       370        380        390        400        410        420 
TLAGLRRRGI LPETIIETII TVGLKVSDAT ISFDNLAALN RKKLDPIAKR LMFVQQPKEF 

       430        440        450        460        470        480 
IIELSEPIRA KIPYNPSKPS EYREILVNPG DKILLDAKDA EEGAVVRLME LCNVTISGNK 

       490        500        510        520        530        540 
LIFHSKTLED AKKLNAKIIQ WVKKDEASNV EVIIPDPNEE KPPISGYGEK EIGNLKINEI 

       550        560 
VQFIRFGFVR VDNKIDNKVT VIFSHE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000023 Genomic DNA. Translation: BAK54565.1.
RefSeqNP_377381.1. NC_003106.2.

3D structure databases

ProteinModelPortalQ971D0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273063.ST1423.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAK54565; BAK54565; STK_14230.
GeneID1459453.
KEGGsto:ST1423.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0008.
HOGENOMHOG000073585.
KOK01885.
OMAMRFAPNP.
ProtClustDBPRK04156.

Enzyme and pathway databases

BioCycSTOK273063:GJC7-1589-MONOMER.

Family and domain databases

Gene3D1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPMF_00022_A. Glu_tRNA_synth_A.
InterProIPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR10119. PTHR10119. 1 hit.
PfamPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSPR00987. TRNASYNTHGLU.
SUPFAMSSF50715. SSF50715. 1 hit.
TIGRFAMsTIGR00463. gltX_arch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYE_SULTO
AccessionPrimary (citable) accession number: Q971D0
Secondary accession number(s): F9VP57
Entry history
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries