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Q970Z6

- SYL2_SULTO

UniProt

Q970Z6 - SYL2_SULTO

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Protein

Leucine--tRNA ligase 2

Gene

leuS2

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei624 – 6241ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-1627-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase 2UniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetase 2UniRule annotation
Short name:
LeuRS 2UniRule annotation
Gene namesi
Name:leuS2UniRule annotation
Ordered Locus Names:STK_14550
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001015: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 944944Leucine--tRNA ligase 2PRO_0000152147Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273063.ST1455.

Structurei

3D structure databases

ProteinModelPortaliQ970Z6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 4611"HIGH" regionAdd
BLAST
Motifi621 – 6255"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q970Z6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSIAEKWQK EWEKAKIFEA NPDRTRNKFF TTVAFPYPNS PFHLGHGRTY
60 70 80 90 100
VTCDIYARYM RMKGYNVLFP MGFHYTGTPI IAMADDVAKG DKELIDIFKN
110 120 130 140 150
IYEIPDNVIS KLADPLFMAN YFRDEIKKAM KEIGLSIDWR REFTTIDPEF
160 170 180 190 200
SSFIVWQFNK LQEKGYIVRD THPVGWCPVH HIPVGMHDTK GDMEPEIGEF
210 220 230 240 250
VLIYFNSDLG ILPAATLRPE TVFGAIGIWV NPDVTYSIIE LDGKKMIVSE
260 270 280 290 300
RAAFKLTFQF DNIKNLGSIK GSELTKYKAV NPITGKEIPI MAADFVDPNV
310 320 330 340 350
ATGIVMSVPA HAPFDYYYLK KNKQQDMQIV SVIQVEGQGD TLAKDLVEKT
360 370 380 390 400
NPKNKDDLQK LTEQVYRIEY NKGKMKDVSS LVKPEFVNYF KSFIGLSVPE
410 420 430 440 450
ARQKVTEFLI EKGLGRKIYE IMNRPVYCRC GNEVVVKILK DQWFLDYGNP
460 470 480 490 500
QWKALAKKLI SNMKFIPPEI RKDFEFVTDW LQKRACARTR GLGTPLPWDK
510 520 530 540 550
KWIIESLSDS TIYMAYYTIS HKIRQYQLKP SQLTYDFWNY IMLGIGDIDK
560 570 580 590 600
ISSETGISKE IIREMRNEFL YWYPLDIRHS GKDLIPNHLS FFIFNHAAIF
610 620 630 640 650
PEELWPKAIA VNGFVLYEGK KMSKSLRNII PLRKALRIYS PDVVRIALTS
660 670 680 690 700
TADMGSDVNF SDSYAKSVGE ILRRYYEFIK ELPKYDGEGS EFANNWLKAQ
710 720 730 740 750
VSSIVLSSTK NMDNIDFRST INDILYSFDS YLREYIDMCK ADGKEPNGKL
760 770 780 790 800
LREVIETWIK LLAPFAPHFA EEIWHELGHT TFISLEKWPT AEESSEDLYY
810 820 830 840 850
ILIHEYHKRI IEDSQKIINY YYKGKPSIVK IYVAEQELMK VLREAVQILS
860 870 880 890 900
NGGTLKQLME KERPSDKKLA NIIRKIYELA VELDDNMKKL ILGYNINERE
910 920 930 940
ILELGTKYMS YKLGIPVEVY DVSKLDKSKY NKEALPLKPA IIVE
Length:944
Mass (Da):109,427
Last modified:June 7, 2004 - v2
Checksum:iCAC4A1005C676676
GO

Sequence cautioni

The sequence BAK54586.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54586.1. Different initiation.
RefSeqiNP_377418.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAK54586; BAK54586; STK_14550.
GeneIDi1459491.
KEGGisto:ST1455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54586.1 . Different initiation.
RefSeqi NP_377418.1. NC_003106.2.

3D structure databases

ProteinModelPortali Q970Z6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273063.ST1455.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAK54586 ; BAK54586 ; STK_14550 .
GeneIDi 1459491.
KEGGi sto:ST1455.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.

Enzyme and pathway databases

BioCyci STOK273063:GJC7-1627-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

Entry informationi

Entry nameiSYL2_SULTO
AccessioniPrimary (citable) accession number: Q970Z6
Secondary accession number(s): F9VNE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: October 29, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3