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Q970Z6

- SYL2_SULTO

UniProt

Q970Z6 - SYL2_SULTO

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Protein

Leucine--tRNA ligase 2

Gene
leuS2, STK_14550
Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei624 – 6241ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-1627-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase 2 (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase 2
Short name:
LeuRS 2
Gene namesi
Name:leuS2
Ordered Locus Names:STK_14550
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001015: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 944944Leucine--tRNA ligase 2UniRule annotationPRO_0000152147Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273063.ST1455.

Structurei

3D structure databases

ProteinModelPortaliQ970Z6.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 4611"HIGH" regionUniRule annotationAdd
BLAST
Motifi621 – 6255"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q970Z6-1 [UniParc]FASTAAdd to Basket

« Hide

MTSIAEKWQK EWEKAKIFEA NPDRTRNKFF TTVAFPYPNS PFHLGHGRTY    50
VTCDIYARYM RMKGYNVLFP MGFHYTGTPI IAMADDVAKG DKELIDIFKN 100
IYEIPDNVIS KLADPLFMAN YFRDEIKKAM KEIGLSIDWR REFTTIDPEF 150
SSFIVWQFNK LQEKGYIVRD THPVGWCPVH HIPVGMHDTK GDMEPEIGEF 200
VLIYFNSDLG ILPAATLRPE TVFGAIGIWV NPDVTYSIIE LDGKKMIVSE 250
RAAFKLTFQF DNIKNLGSIK GSELTKYKAV NPITGKEIPI MAADFVDPNV 300
ATGIVMSVPA HAPFDYYYLK KNKQQDMQIV SVIQVEGQGD TLAKDLVEKT 350
NPKNKDDLQK LTEQVYRIEY NKGKMKDVSS LVKPEFVNYF KSFIGLSVPE 400
ARQKVTEFLI EKGLGRKIYE IMNRPVYCRC GNEVVVKILK DQWFLDYGNP 450
QWKALAKKLI SNMKFIPPEI RKDFEFVTDW LQKRACARTR GLGTPLPWDK 500
KWIIESLSDS TIYMAYYTIS HKIRQYQLKP SQLTYDFWNY IMLGIGDIDK 550
ISSETGISKE IIREMRNEFL YWYPLDIRHS GKDLIPNHLS FFIFNHAAIF 600
PEELWPKAIA VNGFVLYEGK KMSKSLRNII PLRKALRIYS PDVVRIALTS 650
TADMGSDVNF SDSYAKSVGE ILRRYYEFIK ELPKYDGEGS EFANNWLKAQ 700
VSSIVLSSTK NMDNIDFRST INDILYSFDS YLREYIDMCK ADGKEPNGKL 750
LREVIETWIK LLAPFAPHFA EEIWHELGHT TFISLEKWPT AEESSEDLYY 800
ILIHEYHKRI IEDSQKIINY YYKGKPSIVK IYVAEQELMK VLREAVQILS 850
NGGTLKQLME KERPSDKKLA NIIRKIYELA VELDDNMKKL ILGYNINERE 900
ILELGTKYMS YKLGIPVEVY DVSKLDKSKY NKEALPLKPA IIVE 944
Length:944
Mass (Da):109,427
Last modified:June 7, 2004 - v2
Checksum:iCAC4A1005C676676
GO

Sequence cautioni

The sequence BAK54586.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000023 Genomic DNA. Translation: BAK54586.1. Different initiation.
RefSeqiNP_377418.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAK54586; BAK54586; STK_14550.
GeneIDi1459491.
KEGGisto:ST1455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000023 Genomic DNA. Translation: BAK54586.1 . Different initiation.
RefSeqi NP_377418.1. NC_003106.2.

3D structure databases

ProteinModelPortali Q970Z6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273063.ST1455.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAK54586 ; BAK54586 ; STK_14550 .
GeneIDi 1459491.
KEGGi sto:ST1455.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.

Enzyme and pathway databases

BioCyci STOK273063:GJC7-1627-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

Entry informationi

Entry nameiSYL2_SULTO
AccessioniPrimary (citable) accession number: Q970Z6
Secondary accession number(s): F9VNE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: May 14, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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