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Q970Z6

- SYL2_SULTO

UniProt

Q970Z6 - SYL2_SULTO

Protein

Leucine--tRNA ligase 2

Gene

leuS2

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (07 Jun 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei624 – 6241ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSTOK273063:GJC7-1627-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligase 2UniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetase 2UniRule annotation
    Short name:
    LeuRS 2UniRule annotation
    Gene namesi
    Name:leuS2UniRule annotation
    Ordered Locus Names:STK_14550
    OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
    Taxonomic identifieri273063 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001015: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 944944Leucine--tRNA ligase 2PRO_0000152147Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273063.ST1455.

    Structurei

    3D structure databases

    ProteinModelPortaliQ970Z6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi36 – 4611"HIGH" regionAdd
    BLAST
    Motifi621 – 6255"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000216620.
    KOiK01869.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_A. Leu_tRNA_synth_A.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q970Z6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSIAEKWQK EWEKAKIFEA NPDRTRNKFF TTVAFPYPNS PFHLGHGRTY    50
    VTCDIYARYM RMKGYNVLFP MGFHYTGTPI IAMADDVAKG DKELIDIFKN 100
    IYEIPDNVIS KLADPLFMAN YFRDEIKKAM KEIGLSIDWR REFTTIDPEF 150
    SSFIVWQFNK LQEKGYIVRD THPVGWCPVH HIPVGMHDTK GDMEPEIGEF 200
    VLIYFNSDLG ILPAATLRPE TVFGAIGIWV NPDVTYSIIE LDGKKMIVSE 250
    RAAFKLTFQF DNIKNLGSIK GSELTKYKAV NPITGKEIPI MAADFVDPNV 300
    ATGIVMSVPA HAPFDYYYLK KNKQQDMQIV SVIQVEGQGD TLAKDLVEKT 350
    NPKNKDDLQK LTEQVYRIEY NKGKMKDVSS LVKPEFVNYF KSFIGLSVPE 400
    ARQKVTEFLI EKGLGRKIYE IMNRPVYCRC GNEVVVKILK DQWFLDYGNP 450
    QWKALAKKLI SNMKFIPPEI RKDFEFVTDW LQKRACARTR GLGTPLPWDK 500
    KWIIESLSDS TIYMAYYTIS HKIRQYQLKP SQLTYDFWNY IMLGIGDIDK 550
    ISSETGISKE IIREMRNEFL YWYPLDIRHS GKDLIPNHLS FFIFNHAAIF 600
    PEELWPKAIA VNGFVLYEGK KMSKSLRNII PLRKALRIYS PDVVRIALTS 650
    TADMGSDVNF SDSYAKSVGE ILRRYYEFIK ELPKYDGEGS EFANNWLKAQ 700
    VSSIVLSSTK NMDNIDFRST INDILYSFDS YLREYIDMCK ADGKEPNGKL 750
    LREVIETWIK LLAPFAPHFA EEIWHELGHT TFISLEKWPT AEESSEDLYY 800
    ILIHEYHKRI IEDSQKIINY YYKGKPSIVK IYVAEQELMK VLREAVQILS 850
    NGGTLKQLME KERPSDKKLA NIIRKIYELA VELDDNMKKL ILGYNINERE 900
    ILELGTKYMS YKLGIPVEVY DVSKLDKSKY NKEALPLKPA IIVE 944
    Length:944
    Mass (Da):109,427
    Last modified:June 7, 2004 - v2
    Checksum:iCAC4A1005C676676
    GO

    Sequence cautioni

    The sequence BAK54586.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000023 Genomic DNA. Translation: BAK54586.1. Different initiation.
    RefSeqiNP_377418.1. NC_003106.2.

    Genome annotation databases

    EnsemblBacteriaiBAK54586; BAK54586; STK_14550.
    GeneIDi1459491.
    KEGGisto:ST1455.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000023 Genomic DNA. Translation: BAK54586.1 . Different initiation.
    RefSeqi NP_377418.1. NC_003106.2.

    3D structure databases

    ProteinModelPortali Q970Z6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273063.ST1455.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAK54586 ; BAK54586 ; STK_14550 .
    GeneIDi 1459491.
    KEGGi sto:ST1455.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000216620.
    KOi K01869.

    Enzyme and pathway databases

    BioCyci STOK273063:GJC7-1627-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_A. Leu_tRNA_synth_A.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

    Entry informationi

    Entry nameiSYL2_SULTO
    AccessioniPrimary (citable) accession number: Q970Z6
    Secondary accession number(s): F9VNE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3