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Q970Z6 (SYL2_SULTO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase 2

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase 2
Short name=LeuRS 2
Gene names
Name:leuS2
Ordered Locus Names:STK_14550
OrganismSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) [Complete proteome] [HAMAP]
Taxonomic identifier273063 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length944 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Sequence caution

The sequence BAK54586.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 944944Leucine--tRNA ligase 2 HAMAP-Rule MF_00049
PRO_0000152147

Regions

Motif36 – 4611"HIGH" region HAMAP-Rule MF_00049
Motif621 – 6255"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6241ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q970Z6 [UniParc].

Last modified June 7, 2004. Version 2.
Checksum: CAC4A1005C676676

FASTA944109,427
        10         20         30         40         50         60 
MTSIAEKWQK EWEKAKIFEA NPDRTRNKFF TTVAFPYPNS PFHLGHGRTY VTCDIYARYM 

        70         80         90        100        110        120 
RMKGYNVLFP MGFHYTGTPI IAMADDVAKG DKELIDIFKN IYEIPDNVIS KLADPLFMAN 

       130        140        150        160        170        180 
YFRDEIKKAM KEIGLSIDWR REFTTIDPEF SSFIVWQFNK LQEKGYIVRD THPVGWCPVH 

       190        200        210        220        230        240 
HIPVGMHDTK GDMEPEIGEF VLIYFNSDLG ILPAATLRPE TVFGAIGIWV NPDVTYSIIE 

       250        260        270        280        290        300 
LDGKKMIVSE RAAFKLTFQF DNIKNLGSIK GSELTKYKAV NPITGKEIPI MAADFVDPNV 

       310        320        330        340        350        360 
ATGIVMSVPA HAPFDYYYLK KNKQQDMQIV SVIQVEGQGD TLAKDLVEKT NPKNKDDLQK 

       370        380        390        400        410        420 
LTEQVYRIEY NKGKMKDVSS LVKPEFVNYF KSFIGLSVPE ARQKVTEFLI EKGLGRKIYE 

       430        440        450        460        470        480 
IMNRPVYCRC GNEVVVKILK DQWFLDYGNP QWKALAKKLI SNMKFIPPEI RKDFEFVTDW 

       490        500        510        520        530        540 
LQKRACARTR GLGTPLPWDK KWIIESLSDS TIYMAYYTIS HKIRQYQLKP SQLTYDFWNY 

       550        560        570        580        590        600 
IMLGIGDIDK ISSETGISKE IIREMRNEFL YWYPLDIRHS GKDLIPNHLS FFIFNHAAIF 

       610        620        630        640        650        660 
PEELWPKAIA VNGFVLYEGK KMSKSLRNII PLRKALRIYS PDVVRIALTS TADMGSDVNF 

       670        680        690        700        710        720 
SDSYAKSVGE ILRRYYEFIK ELPKYDGEGS EFANNWLKAQ VSSIVLSSTK NMDNIDFRST 

       730        740        750        760        770        780 
INDILYSFDS YLREYIDMCK ADGKEPNGKL LREVIETWIK LLAPFAPHFA EEIWHELGHT 

       790        800        810        820        830        840 
TFISLEKWPT AEESSEDLYY ILIHEYHKRI IEDSQKIINY YYKGKPSIVK IYVAEQELMK 

       850        860        870        880        890        900 
VLREAVQILS NGGTLKQLME KERPSDKKLA NIIRKIYELA VELDDNMKKL ILGYNINERE 

       910        920        930        940 
ILELGTKYMS YKLGIPVEVY DVSKLDKSKY NKEALPLKPA IIVE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000023 Genomic DNA. Translation: BAK54586.1. Different initiation.
RefSeqNP_377418.1. NC_003106.2.

3D structure databases

ProteinModelPortalQ970Z6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273063.ST1455.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAK54586; BAK54586; STK_14550.
GeneID1459491.
KEGGsto:ST1455.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000216620.
KOK01869.
ProtClustDBPRK12300.

Enzyme and pathway databases

BioCycSTOK273063:GJC7-1627-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_A. Leu_tRNA_synth_A.
InterProIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsTIGR00395. leuS_arch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYL2_SULTO
AccessionPrimary (citable) accession number: Q970Z6
Secondary accession number(s): F9VNE0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: April 16, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries