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Q970Y9

- HISX_SULTO

UniProt

Q970Y9 - HISX_SULTO

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Protein
Histidinol dehydrogenase
Gene
hisD, STK_14640
Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei113 – 1131NAD By similarity
Binding sitei172 – 1721NAD By similarity
Binding sitei195 – 1951NAD By similarity
Binding sitei218 – 2181Substrate By similarity
Metal bindingi240 – 2401Zinc By similarity
Binding sitei240 – 2401Substrate By similarity
Metal bindingi243 – 2431Zinc By similarity
Binding sitei243 – 2431Substrate By similarity
Active sitei294 – 2941Proton acceptor By similarity
Active sitei295 – 2951Proton acceptor By similarity
Binding sitei295 – 2951Substrate By similarity
Metal bindingi327 – 3271Zinc By similarity
Binding sitei327 – 3271Substrate By similarity
Binding sitei380 – 3801Substrate By similarity
Metal bindingi385 – 3851Zinc By similarity
Binding sitei385 – 3851Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-1634-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:STK_14640
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001015: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Histidinol dehydrogenaseUniRule annotation
PRO_0000135907Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273063.ST1464.

Structurei

3D structure databases

ProteinModelPortaliQ970Y9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiSQDSRCV.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q970Y9-1 [UniParc]FASTAAdd to Basket

« Hide

MILKELPKQR PNDFTKVLQD VEKIISYVKQ KGDEALIELE EKFDKVKLTS    50
IKFPEVDKLA SQISQDLKMA IDVIFTQIYE FNNSIKPPNI IGGSANGIDY 100
GIMWKSIERV GIYVPGGEKA YPSTLLMAGV PALVAGVKEI YVSSPPTKIN 150
SAIAYISLKL GVKEIYAIGG AQAIAAMAYG TQTVKKVDKI VGPGNIYVQA 200
AKYLVSSDVG IDGIEGPTEL VIIADETANP SNIILDLKAQ AEHGRSTFLV 250
LLSNSDKIIN FVSKELDVDS NIYYVIKVNS IDEAIDIANE IAPEHLSLQI 300
SSAREYLPKV KNAGAVTLGN TPPAIIDYSA GPNHILPTNG WAKIRGGISV 350
YDYLKMIMYA STSNPEKKLV EASKILAKYE GFVFHADSIG VRYE 394
Length:394
Mass (Da):42,933
Last modified:December 1, 2001 - v1
Checksum:iA8606499D3A65AA4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000023 Genomic DNA. Translation: BAB66534.1.
RefSeqiNP_377425.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAB66534; BAB66534; STK_14640.
GeneIDi1459498.
KEGGisto:ST1464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000023 Genomic DNA. Translation: BAB66534.1 .
RefSeqi NP_377425.1. NC_003106.2.

3D structure databases

ProteinModelPortali Q970Y9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273063.ST1464.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB66534 ; BAB66534 ; STK_14640 .
GeneIDi 1459498.
KEGGi sto:ST1464.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi SQDSRCV.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci STOK273063:GJC7-1634-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

Entry informationi

Entry nameiHISX_SULTO
AccessioniPrimary (citable) accession number: Q970Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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