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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei113 – 1131NADUniRule annotation
Binding sitei172 – 1721NADUniRule annotation
Binding sitei195 – 1951NADUniRule annotation
Binding sitei218 – 2181SubstrateUniRule annotation
Metal bindingi240 – 2401ZincUniRule annotation
Binding sitei240 – 2401SubstrateUniRule annotation
Metal bindingi243 – 2431ZincUniRule annotation
Binding sitei243 – 2431SubstrateUniRule annotation
Active sitei294 – 2941Proton acceptorUniRule annotation
Active sitei295 – 2951Proton acceptorUniRule annotation
Binding sitei295 – 2951SubstrateUniRule annotation
Metal bindingi327 – 3271ZincUniRule annotation
Binding sitei327 – 3271SubstrateUniRule annotation
Binding sitei380 – 3801SubstrateUniRule annotation
Metal bindingi385 – 3851ZincUniRule annotation
Binding sitei385 – 3851SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-1634-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:STK_14640
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001015 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Histidinol dehydrogenasePRO_0000135907Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273063.ST1464.

Structurei

3D structure databases

ProteinModelPortaliQ970Y9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiIETFHNA.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q970Y9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILKELPKQR PNDFTKVLQD VEKIISYVKQ KGDEALIELE EKFDKVKLTS
60 70 80 90 100
IKFPEVDKLA SQISQDLKMA IDVIFTQIYE FNNSIKPPNI IGGSANGIDY
110 120 130 140 150
GIMWKSIERV GIYVPGGEKA YPSTLLMAGV PALVAGVKEI YVSSPPTKIN
160 170 180 190 200
SAIAYISLKL GVKEIYAIGG AQAIAAMAYG TQTVKKVDKI VGPGNIYVQA
210 220 230 240 250
AKYLVSSDVG IDGIEGPTEL VIIADETANP SNIILDLKAQ AEHGRSTFLV
260 270 280 290 300
LLSNSDKIIN FVSKELDVDS NIYYVIKVNS IDEAIDIANE IAPEHLSLQI
310 320 330 340 350
SSAREYLPKV KNAGAVTLGN TPPAIIDYSA GPNHILPTNG WAKIRGGISV
360 370 380 390
YDYLKMIMYA STSNPEKKLV EASKILAKYE GFVFHADSIG VRYE
Length:394
Mass (Da):42,933
Last modified:November 30, 2001 - v1
Checksum:iA8606499D3A65AA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAB66534.1.
RefSeqiNP_377425.1. NC_003106.2.
WP_010979512.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAB66534; BAB66534; STK_14640.
GeneIDi1459498.
KEGGisto:ST1464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAB66534.1.
RefSeqiNP_377425.1. NC_003106.2.
WP_010979512.1. NC_003106.2.

3D structure databases

ProteinModelPortaliQ970Y9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273063.ST1464.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB66534; BAB66534; STK_14640.
GeneIDi1459498.
KEGGisto:ST1464.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiIETFHNA.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.
BioCyciSTOK273063:GJC7-1634-MONOMER.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

Entry informationi

Entry nameiHISX_SULTO
AccessioniPrimary (citable) accession number: Q970Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2003
Last sequence update: November 30, 2001
Last modified: January 6, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.