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Q970Y9

- HISX_SULTO

UniProt

Q970Y9 - HISX_SULTO

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei113 – 1131NADUniRule annotation
    Binding sitei172 – 1721NADUniRule annotation
    Binding sitei195 – 1951NADUniRule annotation
    Binding sitei218 – 2181SubstrateUniRule annotation
    Metal bindingi240 – 2401ZincUniRule annotation
    Binding sitei240 – 2401SubstrateUniRule annotation
    Metal bindingi243 – 2431ZincUniRule annotation
    Binding sitei243 – 2431SubstrateUniRule annotation
    Active sitei294 – 2941Proton acceptorUniRule annotation
    Active sitei295 – 2951Proton acceptorUniRule annotation
    Binding sitei295 – 2951SubstrateUniRule annotation
    Metal bindingi327 – 3271ZincUniRule annotation
    Binding sitei327 – 3271SubstrateUniRule annotation
    Binding sitei380 – 3801SubstrateUniRule annotation
    Metal bindingi385 – 3851ZincUniRule annotation
    Binding sitei385 – 3851SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciSTOK273063:GJC7-1634-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:STK_14640
    OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
    Taxonomic identifieri273063 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001015: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 394394Histidinol dehydrogenasePRO_0000135907Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273063.ST1464.

    Structurei

    3D structure databases

    ProteinModelPortaliQ970Y9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiSQDSRCV.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q970Y9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MILKELPKQR PNDFTKVLQD VEKIISYVKQ KGDEALIELE EKFDKVKLTS    50
    IKFPEVDKLA SQISQDLKMA IDVIFTQIYE FNNSIKPPNI IGGSANGIDY 100
    GIMWKSIERV GIYVPGGEKA YPSTLLMAGV PALVAGVKEI YVSSPPTKIN 150
    SAIAYISLKL GVKEIYAIGG AQAIAAMAYG TQTVKKVDKI VGPGNIYVQA 200
    AKYLVSSDVG IDGIEGPTEL VIIADETANP SNIILDLKAQ AEHGRSTFLV 250
    LLSNSDKIIN FVSKELDVDS NIYYVIKVNS IDEAIDIANE IAPEHLSLQI 300
    SSAREYLPKV KNAGAVTLGN TPPAIIDYSA GPNHILPTNG WAKIRGGISV 350
    YDYLKMIMYA STSNPEKKLV EASKILAKYE GFVFHADSIG VRYE 394
    Length:394
    Mass (Da):42,933
    Last modified:December 1, 2001 - v1
    Checksum:iA8606499D3A65AA4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000023 Genomic DNA. Translation: BAB66534.1.
    RefSeqiNP_377425.1. NC_003106.2.

    Genome annotation databases

    EnsemblBacteriaiBAB66534; BAB66534; STK_14640.
    GeneIDi1459498.
    KEGGisto:ST1464.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000023 Genomic DNA. Translation: BAB66534.1 .
    RefSeqi NP_377425.1. NC_003106.2.

    3D structure databases

    ProteinModelPortali Q970Y9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273063.ST1464.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB66534 ; BAB66534 ; STK_14640 .
    GeneIDi 1459498.
    KEGGi sto:ST1464.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi SQDSRCV.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci STOK273063:GJC7-1634-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

    Entry informationi

    Entry nameiHISX_SULTO
    AccessioniPrimary (citable) accession number: Q970Y9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3