Q970X2 (PYRB_SULTO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	STK_14800

Organism

Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) [Complete proteome] [HAMAP]

Taxonomic identifier

273063 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus › Sulfolobus tokodaii

Protein attributes

Sequence length	298 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP-Rule MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP-Rule MF_00001
Subunit structure	Heterooligomer of catalytic and regulatory chains By similarity.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' UMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway 'de novo' pyrimidine nucleobase biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 298	298	Aspartate carbamoyltransferase HAMAP-Rule MF_00001		PRO_0000113260

Sequences

	Sequence		Length	Mass (Da)
	Q970X2 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 4B5F09F08CBD7F52	FASTA	298	34,233
	10 20 30 40 50 60 MKDIISVYDF SKSDFDELFE LADKLRNMST YPKILKEKTV ALAFFEPSTR TYLSFNKAAI 70 80 90 100 110 120 NLGASTIGFS GEEGTSIAKG ENLADTIRML NNYADMIVIR HKFDGAAKFA SEISEIPVIN 130 140 150 160 170 180 AGDGKHEHPT QTVIDFYTIY RNFKNIDGLT FGLMGDLRYA RVVNSFLRAL TRFKPKKVYL 190 200 210 220 230 240 ISPPQLSARK EILEELNYPY REVIDYNEVI EEIDVLYVTR IQKERFPDES EYEKVKESYV 250 260 270 280 290 VDMNLVSKMK KDAIILHALP RVNEISREVD KTPQAKYFEQ ASYAVPVRMA IFHKIVGE

References

[1]

"Complete genome sequence of an aerobic thermoacidophilic Crenarchaeon, Sulfolobus tokodaii strain7." Kawarabayasi Y., Hino Y., Horikawa H., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Otsuka R., Nakazawa H., Takamiya M., Kato Y., Yoshizawa T. , Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Masuda S., Yanagii M., Nishimura M., Yamagishi A., Oshima T., Kikuchi H. DNA Res. 8:123-140(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000023 Genomic DNA. Translation: BAB66551.1.
RefSeq	NP_377442.1. NC_003106.2.
3D structure databases
ProteinModelPortal	Q970X2.
SMR	Q970X2. Positions 1-298.
ModBase	Search...
Protein-protein interaction databases
STRING	273063.ST1480.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAB66551; BAB66551; STK_14800.
GeneID	1459515.
KEGG	sto:ST1480.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HOG000022685.
KO	K00609.
OMA	YGVPVRM.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	STOK273063:GJC7-1651-MONOMER.
UniPathway	UPA00070; UER00116.
Family and domain databases
Gene3D	3.40.50.1370. 2 hits.
HAMAP	MF_00001. Asp_carb_tr.
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR002082. Asp_carbamoyltransf. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_SULTO

Accession

Primary (citable) accession number: Q970X2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 2002
Last sequence update:	December 1, 2001
Last modified:	May 29, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program