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Q970X0

- PYRF_SULTO

UniProt

Q970X0 - PYRF_SULTO

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei6 – 61SubstrateUniRule annotation
    Binding sitei25 – 251SubstrateUniRule annotation
    Active sitei54 – 541Proton donorUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei181 – 1811Substrate; via amide nitrogenUniRule annotation
    Binding sitei182 – 1821SubstrateUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciSTOK273063:GJC7-1653-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:STK_14820
    OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
    Taxonomic identifieri273063 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001015: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 213213Orotidine 5'-phosphate decarboxylasePRO_0000134619Add
    BLAST

    Proteomic databases

    PRIDEiQ970X0.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi273063.ST1482.

    Structurei

    3D structure databases

    ProteinModelPortaliQ970X0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni52 – 6110Substrate bindingUniRule annotation
    Regioni158 – 16811Substrate bindingUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000226069.
    KOiK01591.
    OMAiTEMSHPG.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01200_A. OMPdecase_type1_A.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q970X0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MILSLDRQIP LSTLSEINKY IHKVKIGYPL ILENIEYLDD IVKLHWDEII    50
    FDLKLADIDN TMVLIVSKFI NYADSFIAHS FIGIEGALDK LSEFLKNQNK 100
    SLYLVLSMSH KGWNDEFYPY LKNIAKTIDP KGFVVGATRP NMIRIVRNDF 150
    RDKIIISPGV GAQGAMIGDA ICNGADYEII GRSIYESKDP VTETKKIIET 200
    QEVKINECKR TEN 213
    Length:213
    Mass (Da):24,272
    Last modified:December 1, 2001 - v1
    Checksum:i9A57D1DBC4F41D8C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000023 Genomic DNA. Translation: BAB66553.1.
    RefSeqiNP_377444.1. NC_003106.2.

    Genome annotation databases

    EnsemblBacteriaiBAB66553; BAB66553; STK_14820.
    GeneIDi1459517.
    KEGGisto:ST1482.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000023 Genomic DNA. Translation: BAB66553.1 .
    RefSeqi NP_377444.1. NC_003106.2.

    3D structure databases

    ProteinModelPortali Q970X0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273063.ST1482.

    Proteomic databases

    PRIDEi Q970X0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB66553 ; BAB66553 ; STK_14820 .
    GeneIDi 1459517.
    KEGGi sto:ST1482.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000226069.
    KOi K01591.
    OMAi TEMSHPG.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci STOK273063:GJC7-1653-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01200_A. OMPdecase_type1_A.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

    Entry informationi

    Entry nameiPYRF_SULTO
    AccessioniPrimary (citable) accession number: Q970X0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3