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Q96YN6 (NADK_SULTO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:STK_21360
OrganismSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) [Complete proteome] [HAMAP]
Taxonomic identifier273063 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 248248NAD kinase HAMAP-Rule MF_00361
PRO_0000120710

Regions

Nucleotide binding45 – 462NAD By similarity
Nucleotide binding110 – 1112NAD By similarity

Sites

Active site451Proton acceptor By similarity
Binding site501NAD By similarity
Binding site1381NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q96YN6 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: FBD5BF7C9424C89B

FASTA24827,887
        10         20         30         40         50         60 
MKLKIFTKNS PDAIEFSKYV KNLAENLGFK ITENDPDVVL VIGGDGTLLR AVKDGIPILG 

        70         80         90        100        110        120 
VKFGRRSALL DIRPENIKEA LELLQKNKYT IEEYPMLEAK SKNINTIAFN EIAILFNNPE 

       130        140        150        160        170        180 
TVYGSVNIKE RKILFEGDGV LIATPQGSWA WSYSATRVLL HKDINGIEIT FINPIIPNIK 

       190        200        210        220        230        240 
ALIIPQTETI LVKLEDKGRT QNVRVISDGE IVGNLISKED EELTITLSKR KAKILRFFNL 


IEFDGLFT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000023 Genomic DNA. Translation: BAB67241.1.
RefSeqNP_378132.1. NC_003106.2.

3D structure databases

ProteinModelPortalQ96YN6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273063.ST2136.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB67241; BAB67241; STK_21360.
GeneID1460209.
KEGGsto:ST2136.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000270621.
KOK00858.
OMAMESKGYD.

Enzyme and pathway databases

BioCycSTOK273063:GJC7-2345-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_SULTO
AccessionPrimary (citable) accession number: Q96YN6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families