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Q96YN6

- NADK_SULTO

UniProt

Q96YN6 - NADK_SULTO

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Protein
NAD kinase
Gene
nadK, STK_21360
Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451Proton acceptor By similarity
Binding sitei50 – 501NAD By similarity
Binding sitei138 – 1381NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi45 – 462NAD By similarity
Nucleotide bindingi110 – 1112NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-2345-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:STK_21360
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001015: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248NAD kinaseUniRule annotation
PRO_0000120710Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273063.ST2136.

Structurei

3D structure databases

ProteinModelPortaliQ96YN6.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000270621.
KOiK00858.
OMAiMESKGYD.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96YN6-1 [UniParc]FASTAAdd to Basket

« Hide

MKLKIFTKNS PDAIEFSKYV KNLAENLGFK ITENDPDVVL VIGGDGTLLR    50
AVKDGIPILG VKFGRRSALL DIRPENIKEA LELLQKNKYT IEEYPMLEAK 100
SKNINTIAFN EIAILFNNPE TVYGSVNIKE RKILFEGDGV LIATPQGSWA 150
WSYSATRVLL HKDINGIEIT FINPIIPNIK ALIIPQTETI LVKLEDKGRT 200
QNVRVISDGE IVGNLISKED EELTITLSKR KAKILRFFNL IEFDGLFT 248
Length:248
Mass (Da):27,887
Last modified:December 1, 2001 - v1
Checksum:iFBD5BF7C9424C89B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000023 Genomic DNA. Translation: BAB67241.1.
RefSeqiNP_378132.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAB67241; BAB67241; STK_21360.
GeneIDi1460209.
KEGGisto:ST2136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000023 Genomic DNA. Translation: BAB67241.1 .
RefSeqi NP_378132.1. NC_003106.2.

3D structure databases

ProteinModelPortali Q96YN6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273063.ST2136.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB67241 ; BAB67241 ; STK_21360 .
GeneIDi 1460209.
KEGGi sto:ST2136.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000270621.
KOi K00858.
OMAi MESKGYD.

Enzyme and pathway databases

BioCyci STOK273063:GJC7-2345-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

Entry informationi

Entry nameiNADK_SULTO
AccessioniPrimary (citable) accession number: Q96YN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3