Isocitrate dehydrogenase - Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)

Preferred order of sections

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase EMBL BAB67271.1
EC=1.1.1.42 EMBL BAB67271.1

Gene names

Name:	idh EMBL BAB67271.1
Ordered Locus Names:	STK_21660 EMBL BAB67271.1

Organism

Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) [Complete proteome] [HAMAP]

Taxonomic identifier

273063 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	NADP PDB 2E5M Nucleotide-binding PDB 2E5M
Molecular function	Oxidoreductase EMBL BAB67271.1
Technical term	3D-structure PDB 2E5M PDB 2E0C PDB 2DHT Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Regions

Nucleotide binding

96 – 101

6

NADP PDB 2E5M

Nucleotide binding

327 – 336

10

NADP PDB 2E5M

Sites

Binding site

111

1

NADP PDB 2E5M

Binding site

343

1

NADP; via amide nitrogen and carbonyl oxygen PDB 2E5M

Binding site

386

1

NADP PDB 2E5M

Sequences

Sequence

Length

Mass (Da)

Tools

Q96YK6 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: AA64C3A861DCB22C
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FASTA

409

46,492

        10         20         30         40         50         60 
MLYKEPEDGE KIKFDKGKWI VPNKPVILYI EGDGIGPEIT NAAIKVINKA VERAYGSSRE 

        70         80         90        100        110        120 
IKWLEVYAGE KAEKLVNDRF PKETQEMLLK YRVVLKGPLE TPIGKGWKSV NVAIRLMLDL 

       130        140        150        160        170        180 
YANIRPVKYI EGLESPLKHP EKVDMIIFRE NTDDLYRGIE YPFNSEEAKK IRDFLRKELK 

       190        200        210        220        230        240 
VEIEDDTGIG IKVMSKYKTQ RITRLAIQYA IEHKRKKVTI MHKGNVMKYT EGAFREWAYE 

       250        260        270        280        290        300 
VALKEYRDFI VTEEEINQGK PDQGKIILND RIADNMFQQI IIRPEEYDII LAPNVNGDYI 

       310        320        330        340        350        360 
SDAAGALIGN IGMLGGANIG DEGGMFEAIH GTAPKYAGKN VANPTGIIKA GELMLRWMGW 

       370        380        390        400 
NEAADLIEKA INMAIRDKKV TQDIARFMGV KALGTKEYAD ELIKIMDTI

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of an aerobic thermoacidophilic Crenarchaeon, Sulfolobus tokodaii strain7." Kawarabayasi Y., Hino Y., Horikawa H., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Otsuka R., Nakazawa H., Takamiya M., Kato Y., Yoshizawa T. Kikuchi H. DNA Res. 8:123-140(2001) [PubMed: 11572479] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.
[2]	"crystal structure of isocitrate dehydrogenase from Sulfolobus tokodaii at 2.0 A resolution." Kondo H., Murakami M., Ihara K., Kouyama T. Submitted (OCT-2006) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
[3]	"Crystal structure of isocitrate dehydrogenase of Sulfolobus tokodaii strain7." Kondo H., Murakami M., Ihara K., Suzuki S., Kouyama T. Submitted (MAR-2006) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS).
[4]	"Isocitrate dehydrogenase from Sulfolobus tokodaii strain 7." Kouyama T., Kondo H. Submitted (DEC-2006) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) IN COMPLEX WITH NADP.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BA000023 Genomic DNA. Translation: BAB67271.1.

RefSeq

NP_378162.1. NC_003106.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DHT	X-ray	2.50	A/B	1-409	[»]
2E0C	X-ray	2.00	A/B	1-409	[»]
2E5M	X-ray	2.40	A/B	1-409	[»]

ProteinModelPortal

Q96YK6.

SMR

Q96YK6. Positions 1-409.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

1460239.

GenomeReviews

Gene locus ST2166 in contig BA000023_GR.

KEGG

sto:ST2166.

NMPDR

fig|273063.1.peg.2330.

Organism-specific databases

CMR

Search...

Phylogenomic databases

HOGENOM

HBG518924.

OMA

YMGWKDA.

PhylomeDB

Q96YK6.

ProtClustDB

PRK06451.

Enzyme and pathway databases

BioCyc

STOK273063:ST2166-MONOMER.

Family and domain databases

InterPro

IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]

Gene3D

G3DSA:3.40.718.10. IDH_IMDH. 1 hit.

KO

K00031.

PANTHER

PTHR11835. IDH_IMDH_dimeric. 1 hit.
PTHR11835:SF1. NADP_IDH_prok. 1 hit.

Pfam

PF00180. Iso_dh. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q96YK6_SULTO

Accession

Primary (citable) accession number: Q96YK6

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	December 14, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)