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Protein

Bifunctional phosphoglucose/phosphomannose isomerase

Gene

STK_22450

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency.By similarity

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.
D-mannose 6-phosphate = D-fructose 6-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei198Proton acceptorBy similarity1
Active sitei214Proton donorBy similarity1
Active sitei294Proton acceptorCurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Multifunctional enzyme

Enzyme and pathway databases

BioCyciSTOK273063:G1G3D-2559-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional phosphoglucose/phosphomannose isomerase
Alternative name(s):
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Phosphoglucose isomerase
Short name:
PGI
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Ordered Locus Names:STK_22450
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002277971 – 311Bifunctional phosphoglucose/phosphomannose isomeraseAdd BLAST311

Proteomic databases

PRIDEiQ96YC2

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi273063.ST2245

Structurei

3D structure databases

ProteinModelPortaliQ96YC2
SMRiQ96YC2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 141SISPROSITE-ProRule annotationAdd BLAST123

Sequence similaritiesi

Belongs to the PGI/PMI family.Curated

Phylogenomic databases

eggNOGiarCOG00052 Archaea
COG0166 LUCA
HOGENOMiHOG000270998
KOiK15916
OMAiPELNHNE
OrthoDBiPOG093Z0B0H

Family and domain databases

CDDicd05017 SIS_PGI_PMI_1, 1 hit
cd05637 SIS_PGI_PMI_2, 1 hit
InterProiView protein in InterPro
IPR019490 Glu6P/Mann6P_isomerase_C
IPR011857 PGI/PMI
IPR001347 SIS
IPR035484 SIS_PGI/PMI_1
PfamiView protein in Pfam
PF10432 bact-PGI_C, 1 hit
TIGRFAMsiTIGR02128 G6PI_arch, 1 hit
PROSITEiView protein in PROSITE
PS51464 SIS, 1 hit

Sequencei

Sequence statusi: Complete.

Q96YC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNPYENWIN FFQEALNTNI PSIEKIEELV YLGIGGSGIP GRILEILELP
60 70 80 90 100
VKYQLFRGYK VKVNEKSTVI AVSYSGNTTE TIFALLTSLK KTRKAIVITS
110 120 130 140 150
GGKIEEIASK HNLPVIKLPK GLQTRFVFPY IFTYLIRIIN EGLGTNYNVN
160 170 180 190 200
ELVEGIKDYS KLNEISGILA SQIIGKIPII YSSTFLPIAE RFKQEINENA
210 220 230 240 250
KYPAFYNELP EANHNEIELY SYPSPYTFYP IVIVSDKLDE ESANLINAYK
260 270 280 290 300
IYPLYQSILK NIASLTLLAG LTSVKLAMLL GVKPEQLNII PKIREKTFKL
310
FEGDINADQN L
Length:311
Mass (Da):35,140
Last modified:December 1, 2001 - v1
Checksum:i7539CA4B9C7C6328
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA Translation: BAK54769.1
RefSeqiWP_010980330.1, NC_003106.2

Genome annotation databases

EnsemblBacteriaiBAK54769; BAK54769; STK_22450
GeneIDi1460327
KEGGisto:STK_22450
PATRICifig|273063.9.peg.2546

Similar proteinsi

Entry informationi

Entry nameiPGMI_SULTO
AccessioniPrimary (citable) accession number: Q96YC2
Secondary accession number(s): F9VPC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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