Q96YC2 (PGMI_SULTO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bifunctional phosphoglucose/phosphomannose isomerase

Alternative name(s):
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Mannose-6-phosphate isomerase
EC=5.3.1.8
Phosphoglucose isomerase
Short name=PGI
Phosphomannose isomerase
Short name=PMI

Gene names

Ordered Locus Names:

STK_22450

Organism

Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) [Complete proteome] [HAMAP]

Taxonomic identifier

273063 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency By similarity.
Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. D-mannose 6-phosphate = D-fructose 6-phosphate.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the PGI/PMI family. Contains 1 SIS domain.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC mannose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC sugar binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Bifunctional phosphoglucose/phosphomannose isomerase		PRO_0000227797
Regions
	Domain	19 – 141	123	SIS
Sites
	Active site	198	1	Proton acceptor By similarity
	Active site	214	1	Proton donor By similarity
	Active site	294	1	Proton acceptor Probable

Sequences

	Sequence		Length	Mass (Da)
	Q96YC2 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 7539CA4B9C7C6328	FASTA	311	35,140
	10 20 30 40 50 60 MNNPYENWIN FFQEALNTNI PSIEKIEELV YLGIGGSGIP GRILEILELP VKYQLFRGYK 70 80 90 100 110 120 VKVNEKSTVI AVSYSGNTTE TIFALLTSLK KTRKAIVITS GGKIEEIASK HNLPVIKLPK 130 140 150 160 170 180 GLQTRFVFPY IFTYLIRIIN EGLGTNYNVN ELVEGIKDYS KLNEISGILA SQIIGKIPII 190 200 210 220 230 240 YSSTFLPIAE RFKQEINENA KYPAFYNELP EANHNEIELY SYPSPYTFYP IVIVSDKLDE 250 260 270 280 290 300 ESANLINAYK IYPLYQSILK NIASLTLLAG LTSVKLAMLL GVKPEQLNII PKIREKTFKL 310 FEGDINADQN L

References

[1]

"Complete genome sequence of an aerobic thermoacidophilic Crenarchaeon, Sulfolobus tokodaii strain7." Kawarabayasi Y., Hino Y., Horikawa H., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Otsuka R., Nakazawa H., Takamiya M., Kato Y., Yoshizawa T. , Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Masuda S., Yanagii M., Nishimura M., Yamagishi A., Oshima T., Kikuchi H. DNA Res. 8:123-140(2001) [PubMed: 11572479] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000023 Genomic DNA. Translation: BAK54769.1.
RefSeq	NP_378246.1. NC_003106.2.
3D structure databases
ProteinModelPortal	Q96YC2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1460327.
GenomeReviews	Gene locus ST2245 in contig BA000023_GR.
KEGG	sto:ST2245.
NMPDR	fig|273063.1.peg.2414.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553399.
OMA	MHNDIVG.
ProtClustDB	PRK08674.
Enzyme and pathway databases
BioCyc	STOK273063:ST2245-MONOMER.
Family and domain databases
InterPro	IPR011857. Glu6P/Mann6P_isomerase. IPR019490. Glu6P/Mann6P_isomerase_C. IPR001347. SIS. [Graphical view]
KO	K01809. K01810.
Pfam	PF10432. bact-PGI_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR02128. G6PI_arch. 1 hit.
PROSITE	PS51464. SIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGMI_SULTO

Accession

Primary (citable) accession number: Q96YC2
Secondary accession number(s): F9VPC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	December 1, 2001
Last modified:	December 14, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program