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Q96YC2

- PGMI_SULTO

UniProt

Q96YC2 - PGMI_SULTO

Protein

Bifunctional phosphoglucose/phosphomannose isomerase

Gene

STK_22450

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency.By similarity

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.
    D-mannose 6-phosphate = D-fructose 6-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei198 – 1981Proton acceptorBy similarity
    Active sitei214 – 2141Proton donorBy similarity
    Active sitei294 – 2941Proton acceptorCurated

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glucose-6-phosphate isomerase activity Source: UniProtKB-EC
    3. mannose-6-phosphate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    BioCyciSTOK273063:GJC7-2463-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional phosphoglucose/phosphomannose isomerase
    Alternative name(s):
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Mannose-6-phosphate isomerase (EC:5.3.1.8)
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphomannose isomerase
    Short name:
    PMI
    Gene namesi
    Ordered Locus Names:STK_22450
    OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
    Taxonomic identifieri273063 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001015: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Bifunctional phosphoglucose/phosphomannose isomerasePRO_0000227797Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi273063.ST2245.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96YC2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 141123SISPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PGI/PMI family.Curated
    Contains 1 SIS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000270998.
    KOiK15916.
    OMAiPYENWIN.

    Family and domain databases

    InterProiIPR011857. Glu6P/Mann6P_isomerase.
    IPR019490. Glu6P/Mann6P_isomerase_C.
    IPR001347. SIS.
    [Graphical view]
    PfamiPF10432. bact-PGI_C. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02128. G6PI_arch. 1 hit.
    PROSITEiPS51464. SIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96YC2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNPYENWIN FFQEALNTNI PSIEKIEELV YLGIGGSGIP GRILEILELP    50
    VKYQLFRGYK VKVNEKSTVI AVSYSGNTTE TIFALLTSLK KTRKAIVITS 100
    GGKIEEIASK HNLPVIKLPK GLQTRFVFPY IFTYLIRIIN EGLGTNYNVN 150
    ELVEGIKDYS KLNEISGILA SQIIGKIPII YSSTFLPIAE RFKQEINENA 200
    KYPAFYNELP EANHNEIELY SYPSPYTFYP IVIVSDKLDE ESANLINAYK 250
    IYPLYQSILK NIASLTLLAG LTSVKLAMLL GVKPEQLNII PKIREKTFKL 300
    FEGDINADQN L 311
    Length:311
    Mass (Da):35,140
    Last modified:December 1, 2001 - v1
    Checksum:i7539CA4B9C7C6328
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000023 Genomic DNA. Translation: BAK54769.1.
    RefSeqiNP_378246.1. NC_003106.2.
    WP_010980330.1. NC_003106.2.

    Genome annotation databases

    EnsemblBacteriaiBAK54769; BAK54769; STK_22450.
    GeneIDi1460327.
    KEGGisto:ST2245.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000023 Genomic DNA. Translation: BAK54769.1 .
    RefSeqi NP_378246.1. NC_003106.2.
    WP_010980330.1. NC_003106.2.

    3D structure databases

    ProteinModelPortali Q96YC2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273063.ST2245.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAK54769 ; BAK54769 ; STK_22450 .
    GeneIDi 1460327.
    KEGGi sto:ST2245.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000270998.
    KOi K15916.
    OMAi PYENWIN.

    Enzyme and pathway databases

    BioCyci STOK273063:GJC7-2463-MONOMER.

    Family and domain databases

    InterProi IPR011857. Glu6P/Mann6P_isomerase.
    IPR019490. Glu6P/Mann6P_isomerase_C.
    IPR001347. SIS.
    [Graphical view ]
    Pfami PF10432. bact-PGI_C. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02128. G6PI_arch. 1 hit.
    PROSITEi PS51464. SIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

    Entry informationi

    Entry nameiPGMI_SULTO
    AccessioniPrimary (citable) accession number: Q96YC2
    Secondary accession number(s): F9VPC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3