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Protein

7-cyano-7-deazaguanine synthase 2

Gene

queC2

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ0).By similarity

Catalytic activityi

7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: 7-cyano-7-deazaguanine biosynthesis

This protein is involved in the pathway 7-cyano-7-deazaguanine biosynthesis, which is part of Purine metabolism.
View all proteins of this organism that are known to be involved in the pathway 7-cyano-7-deazaguanine biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2For GATase activityBy similarity1
Metal bindingi426ZincBy similarity1
Metal bindingi434ZincBy similarity1
Metal bindingi437ZincBy similarity1
Metal bindingi440ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi245 – 255ATPBy similarityAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00391.

Names & Taxonomyi

Protein namesi
Recommended name:
7-cyano-7-deazaguanine synthase 2 (EC:6.3.4.20)
Alternative name(s):
7-cyano-7-carbaguanine synthase 2
Archaeosine biosynthesis protein QueC 2
PreQ(0) synthase 2
Gene namesi
Name:queC2
Ordered Locus Names:STK_23180
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002469922 – 4607-cyano-7-deazaguanine synthase 2Add BLAST459

Proteomic databases

PRIDEiQ96Y49.

Interactioni

Protein-protein interaction databases

STRINGi273063.ST2318.

Structurei

3D structure databases

ProteinModelPortaliQ96Y49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 225Glutamine amidotransferase type-2Add BLAST224

Sequence similaritiesi

Belongs to the QueC family.Curated

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiarCOG00039. Archaea.
COG0449. LUCA.
COG0603. LUCA.
HOGENOMiHOG000270539.
KOiK06920.
OMAiNEMEFVR.

Family and domain databases

CDDicd01995. ExsB. 1 hit.
Gene3Di3.40.50.620. 1 hit.
3.60.20.10. 1 hit.
HAMAPiMF_01633. QueC. 1 hit.
InterProiIPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
IPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF13537. GATase_7. 1 hit.
PF06508. QueC. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96Y49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCSVTGVLII KPENYEKIEK KLIQILKRAE DRGRDSFGVI VIEKDGSVRK
60 70 80 90 100
VKALGRPSTQ EEKLYGILDE NSKVIIANNR AEPTTEYVRQ KTEEDIQPFE
110 120 130 140 150
GERYIVTHNG IIANDLELEK KYNVIRRTKI DSAVVPPILD KYWNGEIEQL
160 170 180 190 200
KKILNDIKGS FAFIIGDKKR PNRIYIAQNF KPVYMMYDRE LGAIFFTSLD
210 220 230 240 250
DYFDASAFDS VTKLDPYSIV EVNDNLEIRK IQLLDKKIKK VLVIASGGLD
260 270 280 290 300
STVAATYLLR QGYEITLLHF NYHHKAEERE REAVKKIAEY LQVPLIEIDT
310 320 330 340 350
DLFKIIGHTT LLKGGGEIVK DRLGEEGAEF AHEWVPARNL IFYSVALALA
360 370 380 390 400
EAYGYDAIAS GINLEEAGAY PDNEMEFVRL FAKLSPYATG PNKKVEVMMP
410 420 430 440 450
VGNLVKHEIV KLGVEIGAPL HLTWSCYEGG QKHCGKCGPC YMRKMAFRIN
460
GLNDPVEYEN
Length:460
Mass (Da):52,194
Last modified:December 1, 2001 - v1
Checksum:iF4BCD089C16E032A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54783.1.
RefSeqiWP_010980403.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAK54783; BAK54783; STK_23180.
GeneIDi1460401.
KEGGisto:STK_23180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA. Translation: BAK54783.1.
RefSeqiWP_010980403.1. NC_003106.2.

3D structure databases

ProteinModelPortaliQ96Y49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273063.ST2318.

Proteomic databases

PRIDEiQ96Y49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAK54783; BAK54783; STK_23180.
GeneIDi1460401.
KEGGisto:STK_23180.

Phylogenomic databases

eggNOGiarCOG00039. Archaea.
COG0449. LUCA.
COG0603. LUCA.
HOGENOMiHOG000270539.
KOiK06920.
OMAiNEMEFVR.

Enzyme and pathway databases

UniPathwayiUPA00391.

Family and domain databases

CDDicd01995. ExsB. 1 hit.
Gene3Di3.40.50.620. 1 hit.
3.60.20.10. 1 hit.
HAMAPiMF_01633. QueC. 1 hit.
InterProiIPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
IPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF13537. GATase_7. 1 hit.
PF06508. QueC. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQUEC2_SULTO
AccessioniPrimary (citable) accession number: Q96Y49
Secondary accession number(s): F9VPD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.