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Protein

NAD-dependent alcohol dehydrogenase

Gene

adh

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38Zinc 1; catalyticBy similarity1
Metal bindingi68Zinc 1; catalyticBy similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi154Zinc 1; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciSTOK273063:G1G3D-2906-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD-dependent alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:adh
Ordered Locus Names:STK_25770
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607551 – 347NAD-dependent alcohol dehydrogenaseAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11N6-methyllysineBy similarity1
Modified residuei213N6-methyllysineBy similarity1

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Homodimer and homotetramer.By similarity

Protein-protein interaction databases

STRINGi273063.ST2577

Structurei

Secondary structure

1347
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Beta strandi14 – 17Combined sources4
Beta strandi28 – 37Combined sources10
Helixi40 – 46Combined sources7
Turni54 – 58Combined sources5
Beta strandi62 – 65Combined sources4
Beta strandi70 – 77Combined sources8
Beta strandi89 – 92Combined sources4
Beta strandi99 – 101Combined sources3
Helixi102 – 105Combined sources4
Helixi109 – 111Combined sources3
Beta strandi116 – 118Combined sources3
Turni119 – 121Combined sources3
Beta strandi125 – 133Combined sources9
Helixi135 – 137Combined sources3
Beta strandi138 – 140Combined sources3
Beta strandi142 – 144Combined sources3
Helixi146 – 149Combined sources4
Helixi150 – 153Combined sources4
Helixi155 – 165Combined sources11
Beta strandi173 – 177Combined sources5
Turni178 – 180Combined sources3
Helixi182 – 194Combined sources13
Beta strandi198 – 205Combined sources8
Helixi206 – 215Combined sources10
Beta strandi218 – 222Combined sources5
Turni223 – 225Combined sources3
Helixi228 – 235Combined sources8
Turni236 – 238Combined sources3
Beta strandi241 – 247Combined sources7
Helixi251 – 254Combined sources4
Helixi257 – 260Combined sources4
Beta strandi261 – 269Combined sources9
Beta strandi276 – 280Combined sources5
Helixi281 – 287Combined sources7
Beta strandi290 – 293Combined sources4
Helixi299 – 310Combined sources12
Beta strandi318 – 323Combined sources6
Helixi324 – 326Combined sources3
Helixi327 – 335Combined sources9
Beta strandi341 – 346Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EERX-ray2.10A/B1-347[»]
ProteinModelPortaliQ96XE0
SMRiQ96XE0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96XE0

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01455 Archaea
COG1064 LUCA
HOGENOMiHOG000294685
KOiK13953
OMAiARIPKEC
OrthoDBiPOG093Z07SO

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q96XE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAMRLVEIG KPLKLEDIPI PKPKGSQVLI KIEAAGVCHS DVHMRQGRFG
60 70 80 90 100
NLRIVEDLGV KLPVTLGHEI AGRIEEVGDE VVGYSKGDLV AVNPWEGEGN
110 120 130 140 150
CYYCRIGEEH LCDSPRWLGI NYDGAYAEYV LVPHYKYLYK LRRLSAVEAA
160 170 180 190 200
PLTCSGVTTY RAVRKASLDP SKTLVVIGAG GGLGTMAIQI AKAVSGATII
210 220 230 240 250
GVDVREEALE AAKRAGADYV INASSQDPVS EIRRITQGKG ADAVIDLNNS
260 270 280 290 300
EKTLSIYPYV LAKQGKYVMV GLFGADLKYH APLITLNEVQ FIGSLVGNQS
310 320 330 340
DFLGIMSLAE AGKVKPMVTK TMKLEEANEA IDNLENFKAV GRQVLVP
Length:347
Mass (Da):37,569
Last modified:December 1, 2001 - v1
Checksum:i46059B8AE2382DF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000023 Genomic DNA Translation: BAB67688.1
RefSeqiWP_010980662.1, NC_003106.2

Genome annotation databases

EnsemblBacteriaiBAB67688; BAB67688; STK_25770
GeneIDi1460661
KEGGisto:STK_25770
PATRICifig|273063.9.peg.2903

Similar proteinsi

Entry informationi

Entry nameiADH_SULTO
AccessioniPrimary (citable) accession number: Q96XE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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