ID   HPPD_MAGGR              Reviewed;         419 AA.
AC   Q96X22; A4R2B8;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   16-JUN-2009, entry version 41.
DE   RecName: Full=4-hydroxyphenylpyruvate dioxygenase;
DE            Short=HPPDase;
DE            Short=4HPPD;
DE            Short=HPD;
DE            EC=1.13.11.27;
GN   Name=HPD4; ORFNames=MGG_06691;
OS   Magnaporthe grisea (Rice blast fungus) (Pyricularia grisea).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Magnaporthales; Magnaporthaceae;
OC   Magnaporthe.
OX   NCBI_TaxID=148305;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Guyane 11;
RX   MEDLINE=21221087; PubMed=11296265; DOI=10.1073/pnas.091094198;
RA   Hamer L., Adachi K., Montenegro-Chamorro M.V., Tanzer M., Mahanty S.,
RA   Lo C., Tarpey R.W., Skalchunes A., Heiniger R., Frank S., Darveaux B.,
RA   Lampe D.J., Slater T., Ramamurthy L., Dezwaan T., Nelson G.,
RA   Shuster J., Woessner J., Hamer J.E.;
RT   "Gene discovery and gene function assignment in filamentous fungi.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:5110-5115(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W.,
RA   Harding M., Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J.,
RA   Calvo S.E., Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E.,
RA   Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- CATALYTIC ACTIVITY: 4-hydroxyphenylpyruvate + O(2) = homogentisate
CC       + CO(2).
CC   -!- COFACTOR: Binds 1 iron ion per subunit (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 3/6.
CC   -!- SIMILARITY: Belongs to the 4HPPD family.
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DR   EMBL; AF325533; AAK48714.1; -; Genomic_DNA.
DR   EMBL; CH476830; EDJ98433.1; -; Genomic_DNA.
DR   RefSeq; XP_370194.1; -.
DR   HSSP; P80064; 1CJX.
DR   GeneID; 2684864; -.
DR   KEGG; mgr:MGG_06691; -.
DR   NMPDR; fig|242507.1.peg.10772; -.
DR   OMA; Q96X22; VQDRPTV.
DR   BRENDA; 1.13.11.27; 5953.
DR   GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IEA:EC.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR   InterPro; IPR004360; Glyas_bleo-R_dOase.
DR   PANTHER; PTHR11959; HPP_dOase; 1.
DR   Pfam; PF00903; Glyoxalase; 2.
DR   PIRSF; PIRSF009283; HPP_dOase; 1.
DR   TIGRFAMs; TIGR01263; 4HPPD; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Phenylalanine catabolism; Tyrosine catabolism.
FT   CHAIN         1    419       4-hydroxyphenylpyruvate dioxygenase.
FT                                /FTId=PRO_0000088404.
FT   METAL       219    219       Iron (By similarity).
FT   METAL       302    302       Iron (By similarity).
FT   METAL       387    387       Iron (By similarity).
SQ   SEQUENCE   419 AA;  47576 MW;  642BA6A96C4AFA76 CRC64;
     MSPSAITESP RNSVVDHTSG LQVDSLAVQG PFPSFHGYDH VTWWVGNAKQ AASYYNTLFG
     MKIIAYRGLE TGSRYFASYL VGKEDVRFVF TSPIRSHVHL PEDEPISDED RALLKEMHAH
     LEKHGDAVKD VCFEVDNVQG VYERAVQQGA VSIAPPKTLS DKEHGSVTMA VIQTYGDTTH
     TLLSRDNFRG TFLPGFRDVN RQPAAYSALA PVPLQRIDHC VGNQDWDDMR AACDFYERCL
     SFHRFWSVDD NQISTDFSAL NSIVMASPNN VVKMPINEPA KGKKRSQIEE YVTFNSGAGV
     QHIALLTSDI ITTVEAMRSR GVEFIEVPHT YYDTMRRRLK TEKRDWELQE DFDRLVRNNI
     LIDYDEGGYL LQLFTRPLMD RPTVFIEIIQ RNEFDGFGAG NFKSLFEAIE REQAERGNL
//