Reviewed, UniProtKB/Swiss-Prot Q96X22 (HPPD_MAGGR)

Names and origin

Protein names

Recommended name:
    4-hydroxyphenylpyruvate dioxygenase
      Short name=HPPDase
      Short name=4HPPD
      Short name=HPD
    EC=1.13.11.27

Gene names

Name:	HPD4
ORF Names:	MGG_06691

Organism

Magnaporthe grisea (Rice blast fungus) (Pyricularia grisea) [Complete proteome]

Taxonomic identifier

148305 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Magnaporthales › Magnaporthaceae › Magnaporthe

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.
Sequence similarities	Belongs to the 4HPPD family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-hydroxyphenylpyruvate dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 419	419	4-hydroxyphenylpyruvate dioxygenase		PRO_0000088404
Sites
	Metal binding	219	1	Iron By similarity
	Metal binding	302	1	Iron By similarity
	Metal binding	387	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q96X22-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 642BA6A96C4AFA76	FASTA	419	47,576
	10 20 30 40 50 60 MSPSAITESP RNSVVDHTSG LQVDSLAVQG PFPSFHGYDH VTWWVGNAKQ AASYYNTLFG 70 80 90 100 110 120 MKIIAYRGLE TGSRYFASYL VGKEDVRFVF TSPIRSHVHL PEDEPISDED RALLKEMHAH 130 140 150 160 170 180 LEKHGDAVKD VCFEVDNVQG VYERAVQQGA VSIAPPKTLS DKEHGSVTMA VIQTYGDTTH 190 200 210 220 230 240 TLLSRDNFRG TFLPGFRDVN RQPAAYSALA PVPLQRIDHC VGNQDWDDMR AACDFYERCL 250 260 270 280 290 300 SFHRFWSVDD NQISTDFSAL NSIVMASPNN VVKMPINEPA KGKKRSQIEE YVTFNSGAGV 310 320 330 340 350 360 QHIALLTSDI ITTVEAMRSR GVEFIEVPHT YYDTMRRRLK TEKRDWELQE DFDRLVRNNI 370 380 390 400 410 LIDYDEGGYL LQLFTRPLMD RPTVFIEIIQ RNEFDGFGAG NFKSLFEAIE REQAERGNL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Gene discovery and gene function assignment in filamentous fungi." Hamer L., Adachi K., Montenegro-Chamorro M.V., Tanzer M., Mahanty S., Lo C., Tarpey R.W., Skalchunes A., Heiniger R., Frank S., Darveaux B., Lampe D.J., Slater T., Ramamurthy L., Dezwaan T., Nelson G., Shuster J., Woessner J., Hamer J.E. Proc. Natl. Acad. Sci. U.S.A. 98:5110-5115(2001) [PubMed: 11296265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Guyane 11.
[2]	"The genome sequence of the rice blast fungus Magnaporthe grisea." Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K., Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D., Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S., Soanes D.M. , Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M., Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E., Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W. Nature 434:980-986(2005) [PubMed: 15846337] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 70-15 / FGSC 8958.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF325533 Genomic DNA. Translation: AAK48714.1. CH476830 Genomic DNA. Translation: EDJ98433.1.
RefSeq	XP_370194.1.
3D structure databases
HSSP	HSSP built from PDB template 1CJX based on UniProtKB P80064.
ModBase	Search...
Genome annotation databases
GeneID	2684864.
KEGG	mgr:MGG_06691.
NMPDR	fig|242507.1.peg.10772.
Phylogenomic databases
OMA	VQDRPTV.
Enzyme and pathway databases
BRENDA	1.13.11.27. 5953.
Family and domain databases
InterPro	IPR005956. 4OHPhenylPyrv_dOase. IPR004360. Glyas_bleo-R_dOase. [Graphical view]
PANTHER	PTHR11959. HPP_dOase. 1 hit.
Pfam	PF00903. Glyoxalase. 2 hits. [Graphical view]
PIRSF	PIRSF009283. HPP_dOase. 1 hit.
TIGRFAMs	TIGR01263. 4HPPD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HPPD_MAGGR

Accession

Primary (citable) accession number: Q96X22
Secondary accession number(s): A4R2B8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	December 1, 2001
Last modified:	November 3, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)