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Q96WZ5 (ACEA_PENMA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate lyase

Short name=ICL
Short name=Isocitrase
Short name=Isocitratase
EC=4.1.3.1
Gene names
Name:icl1
OrganismPenicillium marneffei
Taxonomic identifier37727 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces

Protein attributes

Sequence length540 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate = succinate + glyoxylate.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.

Subunit structure

Homotetramer By similarity.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentPeroxisome
   Molecular functionLyase
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisocitrate lyase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 540540Isocitrate lyase
PRO_0000068795

Sites

Active site2081 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q96WZ5 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 3544DC375A692E1B

FASTA54060,493
        10         20         30         40         50         60 
MASTNFDLED QKYLEDVNAV KQWWTDSRWR YTKRPFTAEQ IVAKRGTLKI EYPSNTQAKK 

        70         80         90        100        110        120 
LWKILEERFN DKTVSYTYGC LEPTMLTQMI KYLDTIYVSG WQSSSTASST DEPSPDLADY 

       130        140        150        160        170        180 
PMNTVPNKVN QLFMAQLFHD RKQREERITT PREKRSSVQN YDYLRPIIAD ADTGHGGLTA 

       190        200        210        220        230        240 
VMKLTKLFVE RGAAGIHIED QAPGTKKCGH MAGKVLVPIS EHINRLVAIR AQADIMGTDL 

       250        260        270        280        290        300 
LAIARTDSEA ATLITSTIDY RDHAYLLGST NPSLQPLNDL MVAAEQSGKS GEQLQAIEDS 

       310        320        330        340        350        360 
WIAQAGIKKF DDAVIDTINQ GSFANKKELI NRYLTAAKGK SNSEARAIAK GITGMDIYWN 

       370        380        390        400        410        420 
WDAPRTRGGF YRYQGGTQCA VNRAVAYAPF ADLIWMESKL PDYKQAKEFA DGVHAVWPEQ 

       430        440        450        460        470        480 
KLAYNLSPSF NWKAAMSKEE QLTYIKRLGK LGYCWQFITL AGLHSTALIS DQFASAYAKQ 

       490        500        510        520        530        540 
GMRAYGELIQ EPEMERKVDI VTHQKWSGAN LIDHSLAMVT GGISSTAAMG KGVTEDQFKS 

« Hide

References

[1]"Nucleotide sequence of the isocitrate lyase gene from the pathogenic fungus, Penicillium marneffei."
Haycocks N.G., McGinnis M.R., Cooper C.R. Jr.
Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: PM30.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF373018 Genomic DNA. Translation: AAK54240.1.

3D structure databases

ProteinModelPortalQ96WZ5.
SMRQ96WZ5. Positions 9-522.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00703; UER00719.

Family and domain databases

Gene3D3.20.20.60. 2 hits.
InterProIPR006254. Isocitrate_lyase.
IPR000918. Isocitrate_lyase/Pmutase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamPF00463. ICL. 1 hit.
[Graphical view]
PIRSFPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMSSF51621. SSF51621. 1 hit.
TIGRFAMsTIGR01346. isocit_lyase. 1 hit.
PROSITEPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACEA_PENMA
AccessionPrimary (citable) accession number: Q96WZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: December 1, 2001
Last modified: October 16, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways