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Q96WZ5

- ACEA_PENMA

UniProt

Q96WZ5 - ACEA_PENMA

Protein

Isocitrate lyase

Gene

icl1

Organism
Penicillium marneffei
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei208 – 2081PROSITE-ProRule annotation

    GO - Molecular functioni

    1. isocitrate lyase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-UniPathway
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00703; UER00719.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate lyase (EC:4.1.3.1)
    Short name:
    ICL
    Short name:
    Isocitrase
    Short name:
    Isocitratase
    Gene namesi
    Name:icl1
    OrganismiPenicillium marneffei
    Taxonomic identifieri37727 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces

    Subcellular locationi

    Peroxisome By similarity

    GO - Cellular componenti

    1. peroxisome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 540540Isocitrate lyasePRO_0000068795Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ96WZ5.
    SMRiQ96WZ5. Positions 9-522.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.20.20.60. 2 hits.
    InterProiIPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
    PfamiPF00463. ICL. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
    PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96WZ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASTNFDLED QKYLEDVNAV KQWWTDSRWR YTKRPFTAEQ IVAKRGTLKI    50
    EYPSNTQAKK LWKILEERFN DKTVSYTYGC LEPTMLTQMI KYLDTIYVSG 100
    WQSSSTASST DEPSPDLADY PMNTVPNKVN QLFMAQLFHD RKQREERITT 150
    PREKRSSVQN YDYLRPIIAD ADTGHGGLTA VMKLTKLFVE RGAAGIHIED 200
    QAPGTKKCGH MAGKVLVPIS EHINRLVAIR AQADIMGTDL LAIARTDSEA 250
    ATLITSTIDY RDHAYLLGST NPSLQPLNDL MVAAEQSGKS GEQLQAIEDS 300
    WIAQAGIKKF DDAVIDTINQ GSFANKKELI NRYLTAAKGK SNSEARAIAK 350
    GITGMDIYWN WDAPRTRGGF YRYQGGTQCA VNRAVAYAPF ADLIWMESKL 400
    PDYKQAKEFA DGVHAVWPEQ KLAYNLSPSF NWKAAMSKEE QLTYIKRLGK 450
    LGYCWQFITL AGLHSTALIS DQFASAYAKQ GMRAYGELIQ EPEMERKVDI 500
    VTHQKWSGAN LIDHSLAMVT GGISSTAAMG KGVTEDQFKS 540
    Length:540
    Mass (Da):60,493
    Last modified:December 1, 2001 - v1
    Checksum:i3544DC375A692E1B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF373018 Genomic DNA. Translation: AAK54240.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF373018 Genomic DNA. Translation: AAK54240.1 .

    3D structure databases

    ProteinModelPortali Q96WZ5.
    SMRi Q96WZ5. Positions 9-522.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00719 .

    Family and domain databases

    Gene3Di 3.20.20.60. 2 hits.
    InterProi IPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
    Pfami PF00463. ICL. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    TIGRFAMsi TIGR01346. isocit_lyase. 1 hit.
    PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the isocitrate lyase gene from the pathogenic fungus, Penicillium marneffei."
      Haycocks N.G., McGinnis M.R., Cooper C.R. Jr.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: PM30.

    Entry informationi

    Entry nameiACEA_PENMA
    AccessioniPrimary (citable) accession number: Q96WZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3