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Protein

Isocitrate lyase

Gene

icl1

Organism
Penicillium marneffei
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei208 – 2081PROSITE-ProRule annotation

GO - Molecular functioni

  1. isocitrate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyase (EC:4.1.3.1)
Short name:
ICL
Short name:
Isocitrase
Short name:
Isocitratase
Gene namesi
Name:icl1
OrganismiPenicillium marneffei
Taxonomic identifieri37727 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces

Subcellular locationi

Peroxisome By similarity

GO - Cellular componenti

  1. peroxisome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540Isocitrate lyasePRO_0000068795Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ96WZ5.
SMRiQ96WZ5. Positions 9-522.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.60. 2 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96WZ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASTNFDLED QKYLEDVNAV KQWWTDSRWR YTKRPFTAEQ IVAKRGTLKI
60 70 80 90 100
EYPSNTQAKK LWKILEERFN DKTVSYTYGC LEPTMLTQMI KYLDTIYVSG
110 120 130 140 150
WQSSSTASST DEPSPDLADY PMNTVPNKVN QLFMAQLFHD RKQREERITT
160 170 180 190 200
PREKRSSVQN YDYLRPIIAD ADTGHGGLTA VMKLTKLFVE RGAAGIHIED
210 220 230 240 250
QAPGTKKCGH MAGKVLVPIS EHINRLVAIR AQADIMGTDL LAIARTDSEA
260 270 280 290 300
ATLITSTIDY RDHAYLLGST NPSLQPLNDL MVAAEQSGKS GEQLQAIEDS
310 320 330 340 350
WIAQAGIKKF DDAVIDTINQ GSFANKKELI NRYLTAAKGK SNSEARAIAK
360 370 380 390 400
GITGMDIYWN WDAPRTRGGF YRYQGGTQCA VNRAVAYAPF ADLIWMESKL
410 420 430 440 450
PDYKQAKEFA DGVHAVWPEQ KLAYNLSPSF NWKAAMSKEE QLTYIKRLGK
460 470 480 490 500
LGYCWQFITL AGLHSTALIS DQFASAYAKQ GMRAYGELIQ EPEMERKVDI
510 520 530 540
VTHQKWSGAN LIDHSLAMVT GGISSTAAMG KGVTEDQFKS
Length:540
Mass (Da):60,493
Last modified:December 1, 2001 - v1
Checksum:i3544DC375A692E1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF373018 Genomic DNA. Translation: AAK54240.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF373018 Genomic DNA. Translation: AAK54240.1.

3D structure databases

ProteinModelPortaliQ96WZ5.
SMRiQ96WZ5. Positions 9-522.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Family and domain databases

Gene3Di3.20.20.60. 2 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of the isocitrate lyase gene from the pathogenic fungus, Penicillium marneffei."
    Haycocks N.G., McGinnis M.R., Cooper C.R. Jr.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: PM30.

Entry informationi

Entry nameiACEA_PENMA
AccessioniPrimary (citable) accession number: Q96WZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.