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Q96WX4 (ERG6_PNECA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sterol 24-C-methyltransferase

EC=2.1.1.41
Alternative name(s):
Delta(24)-sterol C-methyltransferase
Gene names
Name:erg6
OrganismPneumocystis carinii
Taxonomic identifier4754 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaPneumocystidomycetesPneumocystidaceaePneumocystis

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol By similarity.

Catalytic activity

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathway

Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Sterol 24-C-methyltransferase
PRO_0000124796

Sequences

Sequence LengthMass (Da)Tools
Q96WX4 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 03708EE1EA885DD5

FASTA37743,228
        10         20         30         40         50         60 
MSFELERIDI EKDREFSEIM HGKDAAKERG LLSSFRKDKE AQKIALDSYF GFWGDKCTSE 

        70         80         90        100        110        120 
KNDIHQQERF KFYATLTRHY YNLVTDFYEY GWSTSFHFCR FAKDESFSQA IARHEHYIAL 

       130        140        150        160        170        180 
HAGIREGETV LDVGCGVGGP ACQISVFTGA NIVGLNNNDY QIQRAKYYSE KKGLSDKLKF 

       190        200        210        220        230        240 
IKGDFMQMPF PENSFDKIYS IEATIHAPSL EGVYSEIYRV LKPGGLYASY EWVMLNKYDE 

       250        260        270        280        290        300 
NDPEHQQIVY GIEIGDSIPK ISKIGEAEAA LIKVGFEIIH SEELSTKNSP LPWYYYLDGD 

       310        320        330        340        350        360 
LRKVRSFRDF ISIARMTTIG KWLISSFIGL MEFIGLLPKG SKKVNDILLV AADSLVKAGK 

       370 
KEIFTPMQLW VCRKPLV 

« Hide

References

[1]"A cDNA clone of S-adenosyl methionine:sterol methyl transferase (SAM:SMT) from Pneumocystis carinii."
Rosenfeld J.A., Stringer J.R., Smulian A.G., Kaneshiro E.S.
Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY032981 mRNA. Translation: AAK54439.1.

3D structure databases

ProteinModelPortalQ96WX4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00768; UER00760.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamPF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMSSF53335. SSF53335. 2 hits.
PROSITEPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameERG6_PNECA
AccessionPrimary (citable) accession number: Q96WX4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways