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Q96WX4

- ERG6_PNECA

UniProt

Q96WX4 - ERG6_PNECA

Protein

Sterol 24-C-methyltransferase

Gene

erg6

Organism
Pneumocystis carinii
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

    Pathwayi

    GO - Molecular functioni

    1. sterol 24-C-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. sterol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00768; UER00760.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sterol 24-C-methyltransferase (EC:2.1.1.41)
    Alternative name(s):
    Delta(24)-sterol C-methyltransferase
    Gene namesi
    Name:erg6
    OrganismiPneumocystis carinii
    Taxonomic identifieri4754 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaPneumocystidomycetesPneumocystidaceaePneumocystis

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 377377Sterol 24-C-methyltransferasePRO_0000124796Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ96WX4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR025810. ERG6.
    IPR013216. Methyltransf_11.
    IPR029063. SAM-dependent_MTases-like.
    IPR013705. Sterol_MeTrfase_C.
    [Graphical view]
    PfamiPF08241. Methyltransf_11. 1 hit.
    PF08498. Sterol_MT_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 2 hits.
    PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96WX4-1 [UniParc]FASTAAdd to Basket

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    MSFELERIDI EKDREFSEIM HGKDAAKERG LLSSFRKDKE AQKIALDSYF    50
    GFWGDKCTSE KNDIHQQERF KFYATLTRHY YNLVTDFYEY GWSTSFHFCR 100
    FAKDESFSQA IARHEHYIAL HAGIREGETV LDVGCGVGGP ACQISVFTGA 150
    NIVGLNNNDY QIQRAKYYSE KKGLSDKLKF IKGDFMQMPF PENSFDKIYS 200
    IEATIHAPSL EGVYSEIYRV LKPGGLYASY EWVMLNKYDE NDPEHQQIVY 250
    GIEIGDSIPK ISKIGEAEAA LIKVGFEIIH SEELSTKNSP LPWYYYLDGD 300
    LRKVRSFRDF ISIARMTTIG KWLISSFIGL MEFIGLLPKG SKKVNDILLV 350
    AADSLVKAGK KEIFTPMQLW VCRKPLV 377
    Length:377
    Mass (Da):43,228
    Last modified:December 1, 2001 - v1
    Checksum:i03708EE1EA885DD5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY032981 mRNA. Translation: AAK54439.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY032981 mRNA. Translation: AAK54439.1 .

    3D structure databases

    ProteinModelPortali Q96WX4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00768 ; UER00760 .

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR025810. ERG6.
    IPR013216. Methyltransf_11.
    IPR029063. SAM-dependent_MTases-like.
    IPR013705. Sterol_MeTrfase_C.
    [Graphical view ]
    Pfami PF08241. Methyltransf_11. 1 hit.
    PF08498. Sterol_MT_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 2 hits.
    PROSITEi PS51685. SAM_MT_ERG6_SMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A cDNA clone of S-adenosyl methionine:sterol methyl transferase (SAM:SMT) from Pneumocystis carinii."
      Rosenfeld J.A., Stringer J.R., Smulian A.G., Kaneshiro E.S.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiERG6_PNECA
    AccessioniPrimary (citable) accession number: Q96WX4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3