Reviewed, UniProtKB/Swiss-Prot Q96WX4 (ERG6_PNECA)

Names and origin

Protein names

Recommended name:
    Sterol 24-C-methyltransferase
    EC=2.1.1.41
Alternative name(s):
    Delta(24)-sterol C-methyltransferase

Gene names

Name:

erg6

Organism

Pneumocystis carinii

Taxonomic identifier

4754 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Pneumocystidomycetes › Pneumocystidaceae › Pneumocystis

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol By similarity.
Catalytic activity	S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.
Pathway	Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5.
Sequence similarities	Belongs to the methyltransferase superfamily. ERG6 family.

Ontologies

Keywords
Biological process	Lipid synthesis Steroid biosynthesis Sterol biosynthesis
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Biological process	sterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sterol 24-C-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 377	377	Sterol 24-C-methyltransferase		PRO_0000124796

Sequences

	Sequence		Length	Mass (Da)
	Q96WX4-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 03708EE1EA885DD5	FASTA	377	43,228
	10 20 30 40 50 60 MSFELERIDI EKDREFSEIM HGKDAAKERG LLSSFRKDKE AQKIALDSYF GFWGDKCTSE 70 80 90 100 110 120 KNDIHQQERF KFYATLTRHY YNLVTDFYEY GWSTSFHFCR FAKDESFSQA IARHEHYIAL 130 140 150 160 170 180 HAGIREGETV LDVGCGVGGP ACQISVFTGA NIVGLNNNDY QIQRAKYYSE KKGLSDKLKF 190 200 210 220 230 240 IKGDFMQMPF PENSFDKIYS IEATIHAPSL EGVYSEIYRV LKPGGLYASY EWVMLNKYDE 250 260 270 280 290 300 NDPEHQQIVY GIEIGDSIPK ISKIGEAEAA LIKVGFEIIH SEELSTKNSP LPWYYYLDGD 310 320 330 340 350 360 LRKVRSFRDF ISIARMTTIG KWLISSFIGL MEFIGLLPKG SKKVNDILLV AADSLVKAGK 370 KEIFTPMQLW VCRKPLV

References

[1]	"A cDNA clone of S-adenosyl methionine:sterol methyl transferase (SAM:SMT) from Pneumocystis carinii." Rosenfeld J.A., Stringer J.R., Smulian A.G., Kaneshiro E.S. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY032981 mRNA. Translation: AAK54439.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.1.1.41. 3409.
Family and domain databases
InterPro	IPR013216. Methyltransf_11. IPR013705. Sterol_MeTrfase_C. [Graphical view]
Pfam	PF08241. Methyltransf_11. 1 hit. PF08498. Sterol_MT_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ERG6_PNECA

Accession

Primary (citable) accession number: Q96WX4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	December 1, 2001
Last modified:	January 20, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)