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Q96WV5 (COPA_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative coatomer subunit alpha
Alternative name(s):
Alpha-coat protein
Short name=Alpha-COP
Gene names
ORF Names:SPBPJ4664.04
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length1207 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins By similarity.

Subunit structure

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits By similarity.

Subcellular location

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.

Sequence similarities

Contains 8 WD repeats.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

P689782EBI-8503699,EBI-4407041From a different organism.
AWRI796_1468E7KC072EBI-8503699,EBI-8503574From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12071207Putative coatomer subunit alpha
PRO_0000316543

Regions

Repeat9 – 5042WD 1
Repeat51 – 9040WD 2
Repeat93 – 13442WD 3
Repeat135 – 17440WD 4
Repeat210 – 24940WD 5
Repeat254 – 29340WD 6
Repeat296 – 33641WD 7
Repeat370 – 41142WD 8

Amino acid modifications

Modified residue4091Phosphoserine Ref.2
Modified residue9421Phosphoserine Ref.2

Secondary structure

................................................................ 1207
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q96WV5 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 4AB701FD7310BE29

FASTA1,207136,369
        10         20         30         40         50         60 
MEMLTKFESR SSRAKGVAFH PTQPWILTSL HNGRIQLWDY RMGTLLDRFD GHDGPVRGIA 

        70         80         90        100        110        120 
FHPTQPLFVS GGDDYKVNVW NYKSRKLLFS LCGHMDYVRV CTFHHEYPWI LSCSDDQTIR 

       130        140        150        160        170        180 
IWNWQSRNCI AILTGHSHYV MCAAFHPSED LIVSASLDQT VRVWDISGLR MKNAAPVSMS 

       190        200        210        220        230        240 
LEDQLAQAHN SISNDLFGST DAIVKFVLEG HDRGVNWCAF HPTLPLILSA GDDRLVKLWR 

       250        260        270        280        290        300 
MTASKAWEVD TCRGHFNNVS CCLFHPHQEL ILSASEDKTI RVWDLNRRTA VQTFRRDNDR 

       310        320        330        340        350        360 
FWFITVHPKL NLFAAAHDSG VMVFKLERER PAHALNINTL LYVNKEKSIV SYDLLRAQST 

       370        380        390        400        410        420 
TVASVKHLGS AWLPPRSLSY NPAEKVALLT SSADNGVYEL VNVSSRSNSL PLKDNIKGPG 

       430        440        450        460        470        480 
DDAIFVARNR FAVFSRSDQT IEIKDLSNKV TKTIQLPEKT RDIFFAGMGH VLLSTATQVH 

       490        500        510        520        530        540 
LFDLQQKKIV SSFNANRVKY VVWSNDNSQA ALLGKHYVYI VKKNLELITS IHETIRIKSA 

       550        560        570        580        590        600 
VWVENNVLLY ATLDHLKYAL MSGDTGVIKT LESTLYLVKA KGNMVFALNR AAEPVSFEID 

       610        620        630        640        650        660 
PTEYLFKLAL LRKDYEQVLH LIQNSNLVGQ AIIAYLQKKG YPEIALQFVE DPSTRFELAL 

       670        680        690        700        710        720 
ECGNLETALE LARTIDRPEV WSRLASDAMS YGNHKIAEIT FQKLRYFEKL SFLYLITGNA 

       730        740        750        760        770        780 
EKLQKMAIIA EKRNDTLSLF QNSLYLNEVE SRINILEQAG MYPIAYLTAK SNGLEEKAQQ 

       790        800        810        820        830        840 
ILSHCNKTEE EIKLPSLGSA FTTPVPVNET YTHNWPLLDT SHSTFEKSLQ ERMEQLAIER 

       850        860        870        880        890        900 
QEEQESEEEY EEVEQSLMDV VDEMSDLAES VPEEEVDGWE VEDLAPEEAV NDVVDDASAF 

       910        920        930        940        950        960 
VGADEIFLWK RNSPLAADHI AAGDFESAMK ILNKQVGAIN FSPLKTRFLE IYTASRVYLP 

       970        980        990       1000       1010       1020 
TISGLDPLVS YVRRNAETAE RSQALPFITR NLASIKSHEL HEAYRLVKAN KILEAQICFR 

      1030       1040       1050       1060       1070       1080 
SIIYLALTTV ANSEEEADEI SALIDECCRY IVALSCELER RRLGEEDTKR ALELSYYFAS 

      1090       1100       1110       1120       1130       1140 
ADLQPMHSII ALRLAINASH KLKNYKSASF LGNKLLQLAE SGPAAEAANR AITLGDRNPH 

      1150       1160       1170       1180       1190       1200 
DAFEIEYDPH VEMRICPKTL TPVYSGDDFD VCSVCGAVYH KGYVNEVCTV CDVGGIGQKG 


TGRRFFA 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409 AND SER-942, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329671 Genomic DNA. Translation: CAC38349.1.
RefSeqNP_595279.1. NM_001021186.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4J87X-ray1.67A3-327[»]
4J8BX-ray1.88A3-327[»]
4J8GX-ray1.90A/B3-327[»]
ProteinModelPortalQ96WV5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid277920. 9 interactions.
IntActQ96WV5. 8 interactions.
MINTMINT-4701710.
STRING4896.SPBPJ4664.04-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBPJ4664.04.1; SPBPJ4664.04.1:pep; SPBPJ4664.04.
GeneID2541412.
KEGGspo:SPBPJ4664.04.

Organism-specific databases

PomBaseSPBPJ4664.04.

Phylogenomic databases

eggNOGCOG2319.
HOGENOMHOG000195913.
KOK05236.
OMAPLAADHI.
OrthoDBEOG7TN016.
PhylomeDBQ96WV5.

Family and domain databases

Gene3D2.130.10.10. 3 hits.
InterProIPR016391. Coatomer_asu.
IPR010714. Coatomer_asu_C.
IPR006692. Coatomer_WD-assoc_reg.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF04053. Coatomer_WDAD. 1 hit.
PF06957. COPI_C. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PIRSFPIRSF003354. Coatomer_alpha_subunit. 1 hit.
PRINTSPR00320. GPROTEINBRPT.
SMARTSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 2 hits.
PROSITEPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20802518.
PROQ96WV5.

Entry information

Entry nameCOPA_SCHPO
AccessionPrimary (citable) accession number: Q96WV5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references