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Q96WV5

- COPA_SCHPO

UniProt

Q96WV5 - COPA_SCHPO

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Protein

Putative coatomer subunit alpha

Gene

SPBPJ4664.04

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).By similarity

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: PomBase
  2. intracellular protein transport Source: InterPro
  3. retrograde vesicle-mediated transport, Golgi to ER Source: PomBase
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Putative coatomer subunit alpha
Alternative name(s):
Alpha-coat protein
Short name:
Alpha-COP
Gene namesi
ORF Names:SPBPJ4664.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBPJ4664.04.

Subcellular locationi

GO - Cellular componenti

  1. COPI vesicle coat Source: PomBase
  2. cytoplasm Source: PomBase
  3. Golgi apparatus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12071207Putative coatomer subunit alphaPRO_0000316543Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei409 – 4091Phosphoserine1 Publication
Modified residuei942 – 9421Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96WV5.

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
P689782EBI-8503699,EBI-4407041From a different organism.
AWRI796_1468E7KC072EBI-8503699,EBI-8503574From a different organism.

Protein-protein interaction databases

BioGridi277920. 9 interactions.
IntActiQ96WV5. 8 interactions.
MINTiMINT-4701710.
STRINGi4896.SPBPJ4664.04-1.

Structurei

Secondary structure

1
1207
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 108
Beta strandi14 – 196
Beta strandi21 – 3010
Beta strandi33 – 397
Turni40 – 434
Beta strandi44 – 507
Beta strandi56 – 616
Beta strandi63 – 7210
Beta strandi77 – 815
Turni82 – 854
Beta strandi86 – 916
Beta strandi98 – 1036
Beta strandi105 – 11410
Beta strandi119 – 1235
Turni124 – 1274
Beta strandi128 – 1336
Beta strandi140 – 1456
Beta strandi147 – 15610
Beta strandi159 – 1657
Helixi167 – 1748
Helixi181 – 1833
Beta strandi202 – 2098
Beta strandi215 – 2206
Beta strandi222 – 23110
Beta strandi234 – 2418
Beta strandi246 – 2538
Beta strandi259 – 2646
Beta strandi266 – 27510
Beta strandi278 – 2847
Turni285 – 2873
Beta strandi290 – 2956
Beta strandi301 – 3066
Beta strandi308 – 3114
Beta strandi313 – 3175
Beta strandi320 – 3267

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4J87X-ray1.67A1-327[»]
4J8BX-ray1.88A1-327[»]
4J8GX-ray1.90A/B1-327[»]
ProteinModelPortaliQ96WV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati9 – 5042WD 1Add
BLAST
Repeati51 – 9040WD 2Add
BLAST
Repeati93 – 13442WD 3Add
BLAST
Repeati135 – 17440WD 4Add
BLAST
Repeati210 – 24940WD 5Add
BLAST
Repeati254 – 29340WD 6Add
BLAST
Repeati296 – 33641WD 7Add
BLAST
Repeati370 – 41142WD 8Add
BLAST

Sequence similaritiesi

Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000195913.
InParanoidiQ96WV5.
KOiK05236.
OMAiDRPECWE.
OrthoDBiEOG7TN016.
PhylomeDBiQ96WV5.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR016391. Coatomer_asu.
IPR010714. Coatomer_asu_C.
IPR006692. Coatomer_WD-assoc_reg.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04053. Coatomer_WDAD. 1 hit.
PF06957. COPI_C. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PIRSFiPIRSF003354. Coatomer_alpha_subunit. 1 hit.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96WV5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEMLTKFESR SSRAKGVAFH PTQPWILTSL HNGRIQLWDY RMGTLLDRFD
60 70 80 90 100
GHDGPVRGIA FHPTQPLFVS GGDDYKVNVW NYKSRKLLFS LCGHMDYVRV
110 120 130 140 150
CTFHHEYPWI LSCSDDQTIR IWNWQSRNCI AILTGHSHYV MCAAFHPSED
160 170 180 190 200
LIVSASLDQT VRVWDISGLR MKNAAPVSMS LEDQLAQAHN SISNDLFGST
210 220 230 240 250
DAIVKFVLEG HDRGVNWCAF HPTLPLILSA GDDRLVKLWR MTASKAWEVD
260 270 280 290 300
TCRGHFNNVS CCLFHPHQEL ILSASEDKTI RVWDLNRRTA VQTFRRDNDR
310 320 330 340 350
FWFITVHPKL NLFAAAHDSG VMVFKLERER PAHALNINTL LYVNKEKSIV
360 370 380 390 400
SYDLLRAQST TVASVKHLGS AWLPPRSLSY NPAEKVALLT SSADNGVYEL
410 420 430 440 450
VNVSSRSNSL PLKDNIKGPG DDAIFVARNR FAVFSRSDQT IEIKDLSNKV
460 470 480 490 500
TKTIQLPEKT RDIFFAGMGH VLLSTATQVH LFDLQQKKIV SSFNANRVKY
510 520 530 540 550
VVWSNDNSQA ALLGKHYVYI VKKNLELITS IHETIRIKSA VWVENNVLLY
560 570 580 590 600
ATLDHLKYAL MSGDTGVIKT LESTLYLVKA KGNMVFALNR AAEPVSFEID
610 620 630 640 650
PTEYLFKLAL LRKDYEQVLH LIQNSNLVGQ AIIAYLQKKG YPEIALQFVE
660 670 680 690 700
DPSTRFELAL ECGNLETALE LARTIDRPEV WSRLASDAMS YGNHKIAEIT
710 720 730 740 750
FQKLRYFEKL SFLYLITGNA EKLQKMAIIA EKRNDTLSLF QNSLYLNEVE
760 770 780 790 800
SRINILEQAG MYPIAYLTAK SNGLEEKAQQ ILSHCNKTEE EIKLPSLGSA
810 820 830 840 850
FTTPVPVNET YTHNWPLLDT SHSTFEKSLQ ERMEQLAIER QEEQESEEEY
860 870 880 890 900
EEVEQSLMDV VDEMSDLAES VPEEEVDGWE VEDLAPEEAV NDVVDDASAF
910 920 930 940 950
VGADEIFLWK RNSPLAADHI AAGDFESAMK ILNKQVGAIN FSPLKTRFLE
960 970 980 990 1000
IYTASRVYLP TISGLDPLVS YVRRNAETAE RSQALPFITR NLASIKSHEL
1010 1020 1030 1040 1050
HEAYRLVKAN KILEAQICFR SIIYLALTTV ANSEEEADEI SALIDECCRY
1060 1070 1080 1090 1100
IVALSCELER RRLGEEDTKR ALELSYYFAS ADLQPMHSII ALRLAINASH
1110 1120 1130 1140 1150
KLKNYKSASF LGNKLLQLAE SGPAAEAANR AITLGDRNPH DAFEIEYDPH
1160 1170 1180 1190 1200
VEMRICPKTL TPVYSGDDFD VCSVCGAVYH KGYVNEVCTV CDVGGIGQKG

TGRRFFA
Length:1,207
Mass (Da):136,369
Last modified:December 1, 2001 - v1
Checksum:i4AB701FD7310BE29
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAC38349.1.
RefSeqiNP_595279.1. NM_001021186.2.

Genome annotation databases

EnsemblFungiiSPBPJ4664.04.1; SPBPJ4664.04.1:pep; SPBPJ4664.04.
GeneIDi2541412.
KEGGispo:SPBPJ4664.04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAC38349.1 .
RefSeqi NP_595279.1. NM_001021186.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4J87 X-ray 1.67 A 1-327 [» ]
4J8B X-ray 1.88 A 1-327 [» ]
4J8G X-ray 1.90 A/B 1-327 [» ]
ProteinModelPortali Q96WV5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277920. 9 interactions.
IntActi Q96WV5. 8 interactions.
MINTi MINT-4701710.
STRINGi 4896.SPBPJ4664.04-1.

Proteomic databases

MaxQBi Q96WV5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBPJ4664.04.1 ; SPBPJ4664.04.1:pep ; SPBPJ4664.04 .
GeneIDi 2541412.
KEGGi spo:SPBPJ4664.04.

Organism-specific databases

PomBasei SPBPJ4664.04.

Phylogenomic databases

eggNOGi COG2319.
HOGENOMi HOG000195913.
InParanoidi Q96WV5.
KOi K05236.
OMAi DRPECWE.
OrthoDBi EOG7TN016.
PhylomeDBi Q96WV5.

Miscellaneous databases

NextBioi 20802518.
PROi Q96WV5.

Family and domain databases

Gene3Di 2.130.10.10. 3 hits.
InterProi IPR016391. Coatomer_asu.
IPR010714. Coatomer_asu_C.
IPR006692. Coatomer_WD-assoc_reg.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF04053. Coatomer_WDAD. 1 hit.
PF06957. COPI_C. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view ]
PIRSFi PIRSF003354. Coatomer_alpha_subunit. 1 hit.
PRINTSi PR00320. GPROTEINBRPT.
SMARTi SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 2 hits.
PROSITEi PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409 AND SER-942, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiCOPA_SCHPO
AccessioniPrimary (citable) accession number: Q96WV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3