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Q96WV5

- COPA_SCHPO

UniProt

Q96WV5 - COPA_SCHPO

Protein

Putative coatomer subunit alpha

Gene

SPBPJ4664.04

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: PomBase
    2. intracellular protein transport Source: InterPro
    3. retrograde vesicle-mediated transport, Golgi to ER Source: PomBase

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative coatomer subunit alpha
    Alternative name(s):
    Alpha-coat protein
    Short name:
    Alpha-COP
    Gene namesi
    ORF Names:SPBPJ4664.04
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBPJ4664.04.

    Subcellular locationi

    GO - Cellular componenti

    1. COPI vesicle coat Source: PomBase
    2. cytoplasm Source: PomBase
    3. Golgi apparatus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12071207Putative coatomer subunit alphaPRO_0000316543Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei409 – 4091Phosphoserine1 Publication
    Modified residuei942 – 9421Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96WV5.

    Interactioni

    Subunit structurei

    Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    P689782EBI-8503699,EBI-4407041From a different organism.
    AWRI796_1468E7KC072EBI-8503699,EBI-8503574From a different organism.

    Protein-protein interaction databases

    BioGridi277920. 9 interactions.
    IntActiQ96WV5. 8 interactions.
    MINTiMINT-4701710.
    STRINGi4896.SPBPJ4664.04-1.

    Structurei

    Secondary structure

    1
    1207
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 108
    Beta strandi14 – 196
    Beta strandi21 – 3010
    Beta strandi33 – 397
    Turni40 – 434
    Beta strandi44 – 507
    Beta strandi56 – 616
    Beta strandi63 – 7210
    Beta strandi77 – 815
    Turni82 – 854
    Beta strandi86 – 916
    Beta strandi98 – 1036
    Beta strandi105 – 11410
    Beta strandi119 – 1235
    Turni124 – 1274
    Beta strandi128 – 1336
    Beta strandi140 – 1456
    Beta strandi147 – 15610
    Beta strandi159 – 1657
    Helixi167 – 1748
    Helixi181 – 1833
    Beta strandi202 – 2098
    Beta strandi215 – 2206
    Beta strandi222 – 23110
    Beta strandi234 – 2418
    Beta strandi246 – 2538
    Beta strandi259 – 2646
    Beta strandi266 – 27510
    Beta strandi278 – 2847
    Turni285 – 2873
    Beta strandi290 – 2956
    Beta strandi301 – 3066
    Beta strandi308 – 3114
    Beta strandi313 – 3175
    Beta strandi320 – 3267

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4J87X-ray1.67A1-327[»]
    4J8BX-ray1.88A1-327[»]
    4J8GX-ray1.90A/B1-327[»]
    ProteinModelPortaliQ96WV5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati9 – 5042WD 1Add
    BLAST
    Repeati51 – 9040WD 2Add
    BLAST
    Repeati93 – 13442WD 3Add
    BLAST
    Repeati135 – 17440WD 4Add
    BLAST
    Repeati210 – 24940WD 5Add
    BLAST
    Repeati254 – 29340WD 6Add
    BLAST
    Repeati296 – 33641WD 7Add
    BLAST
    Repeati370 – 41142WD 8Add
    BLAST

    Sequence similaritiesi

    Contains 8 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000195913.
    KOiK05236.
    OMAiDRPECWE.
    OrthoDBiEOG7TN016.
    PhylomeDBiQ96WV5.

    Family and domain databases

    Gene3Di2.130.10.10. 3 hits.
    InterProiIPR016391. Coatomer_asu.
    IPR010714. Coatomer_asu_C.
    IPR006692. Coatomer_WD-assoc_reg.
    IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF04053. Coatomer_WDAD. 1 hit.
    PF06957. COPI_C. 1 hit.
    PF00400. WD40. 6 hits.
    [Graphical view]
    PIRSFiPIRSF003354. Coatomer_alpha_subunit. 1 hit.
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 2 hits.
    PROSITEiPS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96WV5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEMLTKFESR SSRAKGVAFH PTQPWILTSL HNGRIQLWDY RMGTLLDRFD     50
    GHDGPVRGIA FHPTQPLFVS GGDDYKVNVW NYKSRKLLFS LCGHMDYVRV 100
    CTFHHEYPWI LSCSDDQTIR IWNWQSRNCI AILTGHSHYV MCAAFHPSED 150
    LIVSASLDQT VRVWDISGLR MKNAAPVSMS LEDQLAQAHN SISNDLFGST 200
    DAIVKFVLEG HDRGVNWCAF HPTLPLILSA GDDRLVKLWR MTASKAWEVD 250
    TCRGHFNNVS CCLFHPHQEL ILSASEDKTI RVWDLNRRTA VQTFRRDNDR 300
    FWFITVHPKL NLFAAAHDSG VMVFKLERER PAHALNINTL LYVNKEKSIV 350
    SYDLLRAQST TVASVKHLGS AWLPPRSLSY NPAEKVALLT SSADNGVYEL 400
    VNVSSRSNSL PLKDNIKGPG DDAIFVARNR FAVFSRSDQT IEIKDLSNKV 450
    TKTIQLPEKT RDIFFAGMGH VLLSTATQVH LFDLQQKKIV SSFNANRVKY 500
    VVWSNDNSQA ALLGKHYVYI VKKNLELITS IHETIRIKSA VWVENNVLLY 550
    ATLDHLKYAL MSGDTGVIKT LESTLYLVKA KGNMVFALNR AAEPVSFEID 600
    PTEYLFKLAL LRKDYEQVLH LIQNSNLVGQ AIIAYLQKKG YPEIALQFVE 650
    DPSTRFELAL ECGNLETALE LARTIDRPEV WSRLASDAMS YGNHKIAEIT 700
    FQKLRYFEKL SFLYLITGNA EKLQKMAIIA EKRNDTLSLF QNSLYLNEVE 750
    SRINILEQAG MYPIAYLTAK SNGLEEKAQQ ILSHCNKTEE EIKLPSLGSA 800
    FTTPVPVNET YTHNWPLLDT SHSTFEKSLQ ERMEQLAIER QEEQESEEEY 850
    EEVEQSLMDV VDEMSDLAES VPEEEVDGWE VEDLAPEEAV NDVVDDASAF 900
    VGADEIFLWK RNSPLAADHI AAGDFESAMK ILNKQVGAIN FSPLKTRFLE 950
    IYTASRVYLP TISGLDPLVS YVRRNAETAE RSQALPFITR NLASIKSHEL 1000
    HEAYRLVKAN KILEAQICFR SIIYLALTTV ANSEEEADEI SALIDECCRY 1050
    IVALSCELER RRLGEEDTKR ALELSYYFAS ADLQPMHSII ALRLAINASH 1100
    KLKNYKSASF LGNKLLQLAE SGPAAEAANR AITLGDRNPH DAFEIEYDPH 1150
    VEMRICPKTL TPVYSGDDFD VCSVCGAVYH KGYVNEVCTV CDVGGIGQKG 1200
    TGRRFFA 1207
    Length:1,207
    Mass (Da):136,369
    Last modified:December 1, 2001 - v1
    Checksum:i4AB701FD7310BE29
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAC38349.1.
    RefSeqiNP_595279.1. NM_001021186.2.

    Genome annotation databases

    EnsemblFungiiSPBPJ4664.04.1; SPBPJ4664.04.1:pep; SPBPJ4664.04.
    GeneIDi2541412.
    KEGGispo:SPBPJ4664.04.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAC38349.1 .
    RefSeqi NP_595279.1. NM_001021186.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4J87 X-ray 1.67 A 1-327 [» ]
    4J8B X-ray 1.88 A 1-327 [» ]
    4J8G X-ray 1.90 A/B 1-327 [» ]
    ProteinModelPortali Q96WV5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277920. 9 interactions.
    IntActi Q96WV5. 8 interactions.
    MINTi MINT-4701710.
    STRINGi 4896.SPBPJ4664.04-1.

    Proteomic databases

    MaxQBi Q96WV5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBPJ4664.04.1 ; SPBPJ4664.04.1:pep ; SPBPJ4664.04 .
    GeneIDi 2541412.
    KEGGi spo:SPBPJ4664.04.

    Organism-specific databases

    PomBasei SPBPJ4664.04.

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000195913.
    KOi K05236.
    OMAi DRPECWE.
    OrthoDBi EOG7TN016.
    PhylomeDBi Q96WV5.

    Miscellaneous databases

    NextBioi 20802518.
    PROi Q96WV5.

    Family and domain databases

    Gene3Di 2.130.10.10. 3 hits.
    InterProi IPR016391. Coatomer_asu.
    IPR010714. Coatomer_asu_C.
    IPR006692. Coatomer_WD-assoc_reg.
    IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF04053. Coatomer_WDAD. 1 hit.
    PF06957. COPI_C. 1 hit.
    PF00400. WD40. 6 hits.
    [Graphical view ]
    PIRSFi PIRSF003354. Coatomer_alpha_subunit. 1 hit.
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 2 hits.
    PROSITEi PS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409 AND SER-942, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiCOPA_SCHPO
    AccessioniPrimary (citable) accession number: Q96WV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3