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Q96WP7 (PYRF_ASPKA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:pyrG
OrganismAspergillus kawachii (White koji mold) (Aspergillus awamori var. kawachi)
Taxonomic identifier40384 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277Orotidine 5'-phosphate decarboxylase
PRO_0000134642

Regions

Region62 – 643Substrate binding By similarity
Region93 – 10210Substrate binding By similarity

Sites

Active site951Proton donor By similarity
Binding site401Substrate By similarity
Binding site2291Substrate By similarity
Binding site2471Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q96WP7 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 4203C6F94FFF2722

FASTA27730,099
        10         20         30         40         50         60 
MSSKSQLTYT ARASKHPNAL AKRLFEIAEA KKTNVTVSAD VTTTKELLDL ADRLGPYIAV 

        70         80         90        100        110        120 
IKTHIDILSD FSDETIEGLK ALAQKHIFLI FEDRKFIDIG NTVQKQYHRG TLRISEWAHI 

       130        140        150        160        170        180 
INCSILPGEG IVEALAQTAS APDFGYGPER GLLILAEMTS KGSLATGQYT TSSVDYARKS 

       190        200        210        220        230        240 
KNFVMGFVST RPLGEVQSEV SSPSDEEDFV VFTTGVNISS KGDKLGQQYQ TPASAIGRGA 

       250        260        270 
DFIIAGRGIY AAPDPVQAAQ QYQKEGWEAY LARVGGN 

« Hide

References

[1]"Aspergillus kawachii pyrG gene for orotidine-5'-phosphate decarboxylase, complete cds."
Iwashita K., Ito K.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB064659 Genomic DNA. Translation: BAB62023.1.

3D structure databases

ProteinModelPortalQ96WP7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_ASPKA
AccessionPrimary (citable) accession number: Q96WP7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 1, 2001
Last modified: November 13, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways