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Protein

Laccase-2

Gene

lcc2

Organism
Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi125Copper 1; type 2By similarity1
Metal bindingi127Copper 2; type 3By similarity1
Metal bindingi169Copper 2; type 3By similarity1
Metal bindingi171Copper 3; type 3By similarity1
Metal bindingi464Copper 4; type 1By similarity1
Metal bindingi467Copper 1; type 2By similarity1
Metal bindingi469Copper 3; type 3By similarity1
Metal bindingi526Copper 3; type 3By similarity1
Metal bindingi527Copper 4; type 1By similarity1
Metal bindingi528Copper 2; type 3By similarity1
Metal bindingi532Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLignin degradation
LigandCopper, Metal-binding

Protein family/group databases

CAZyiAA1. Auxiliary Activities 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-2 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 2
Diphenol oxidase 2
Urishiol oxidase 2
Gene namesi
Name:lcc2
OrganismiBotryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea)
Taxonomic identifieri40559 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeBotrytis

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000026763820 – 581Laccase-2Add BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi343N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi408N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi427N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Inductioni

By resveratrol and tannins.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ96WM9.
SMRiQ96WM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 191Plastocyanin-like 1Add BLAST118
Domaini197 – 353Plastocyanin-like 2Add BLAST157
Domaini413 – 547Plastocyanin-like 3Add BLAST135

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiView protein in InterPro
IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
PfamiView protein in Pfam
PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiView protein in PROSITE
PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96WM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYSTVFTAL TALFAQASAT AIPAVRSPLA PRQSTTASCA NSATSRSCWG
60 70 80 90 100
EYSIDTNWYD VTPNTGVTRE YWLSVENSTI TPDGYTRSAM TFNGTVPGPA
110 120 130 140 150
ITADWGDNLI IHVTNNLQHN GTSIHWHGIR QLGSLEYDGV PGVTQCPIAP
160 170 180 190 200
GDTLTYKFQA TQYGTTWYHS HFSLQYADGL FGPLIINGPA TADYDEDVGA
210 220 230 240 250
IFLQDWAHKS VFEIWDSARQ GAPPALENTL MNGTNIYDCS ASTDANCVGG
260 270 280 290 300
GKKFELTFVE GTKYRLRLIN VGIDSHFEFA IDNHTLTVIA NDLVPIVPYT
310 320 330 340 350
TDTLLIGIGQ RYDVIVEANA AADNYWIRGN WGTTCSSNSE AANATGILRY
360 370 380 390 400
DSSSTVDPTS VGVTPRGTCA DEPVASLVPH LALDVGGYSL VDEQVSFAFT
410 420 430 440 450
NYFTWTINSS SLLLDWSSPT TLKIFNNETI FPTDYNVVAL NQTDANEEWV
460 470 480 490 500
VYVIEDLTGF GIWHPIHLHG HDFYVVAQET DVFSATKSPA NFNLVNPPRR
510 520 530 540 550
DVAALPGNGY LAIAFKLDNP GSWLLHCHIA WHASEGLAMQ FVESQSSIAI
560 570 580
GMSDTDIFED TCANWNAYTP TELFAEDDSG I
Length:581
Mass (Da):63,434
Last modified:December 1, 2001 - v1
Checksum:i674947DAFD6BC757
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF243855 Genomic DNA. Translation: AAK77953.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLAC2_BOTFU
AccessioniPrimary (citable) accession number: Q96WM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: July 5, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families