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Q96WL3 (URE2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein URE2
Gene names
Name:URE2
ORF Names:CaO19.155, CaO19.7794
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the GST superfamily.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Protein URE2
PRO_0000186004

Regions

Domain102 – 18685GST N-terminal
Domain195 – 344150GST C-terminal

Sequences

Sequence LengthMass (Da)Tools
Q96WL3 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 09D18470BF36C0CD

FASTA34439,136
        10         20         30         40         50         60 
MMSTDQHIQQ NMNDNSNNSN NSNNNNTNNN NNNQSVNVNV NNTNNNTQTI SNLSAGLKSV 

        70         80         90        100        110        120 
SLTDQQQNEV NLNLLQQQLH QEASTQQQQS RITQFFQNQP TEGFTLFSHR SAPNGFKVAI 

       130        140        150        160        170        180 
ILSELNLPFN TFFLDFNNGE QRTPEFVTIN PNARVPALID HYNDNTSIWE SGAITLYLVS 

       190        200        210        220        230        240 
KYLKENGECS LWSNNLIEQS QISSWLFFQT SGHAPMIGQA LHFRYFHSCP VPSAVERYTD 

       250        260        270        280        290        300 
EVRRVYGVIE MALAERREAL IMDLDVENAA AYSAGTTPLS QSRFFDHPVW LVGDRTTVAD 

       310        320        330        340 
LSFVPWNNVV DRIGINLKVE FPEVYKWTKH MMQRPAVKRA LRGD 

« Hide

References

« Hide 'large scale' references
[1]"Prion characteristics of the URE2 protein of various yeast species."
Fernandez-Bellot E., Baudin-Baillieu A., Cullin C.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Conservation of a portion of the S. cerevisiae Ure2p prion domain that interacts with the full-length protein."
Edskes H.K., Wickner R.B.
Proc. Natl. Acad. Sci. U.S.A. 99:16384-16391(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Darlington.
[3]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF260777 Genomic DNA. Translation: AAK51643.2.
AF525173 Genomic DNA. Translation: AAM91946.1.
AACQ01000255 Genomic DNA. Translation: EAK91340.1.
AACQ01000254 Genomic DNA. Translation: EAK91354.1.
RefSeqXP_710592.1. XM_705500.1.
XP_710606.1. XM_705514.1.

3D structure databases

ProteinModelPortalQ96WL3.
SMRQ96WL3. Positions 88-344.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0003152.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3647795.
3647808.
KEGGcal:CaO19.155.
cal:CaO19.7794.

Organism-specific databases

CGDCAL0003152. URE2.

Phylogenomic databases

eggNOGCOG0625.
KOK00799.
OrthoDBEOG7KWSWX.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR017298. Prion_URE2.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PIRSFPIRSF037861. Prion_URE2. 1 hit.
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameURE2_CANAL
AccessionPrimary (citable) accession number: Q96WL3
Secondary accession number(s): Q59LH8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names