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Q96WL3

- URE2_CANAL

UniProt

Q96WL3 - URE2_CANAL

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Protein
Protein URE2
Gene
URE2, CaO19.155, CaO19.7794
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine By similarity.

GO - Molecular functioni

  1. transcription corepressor activity Source: CGD

GO - Biological processi

  1. nitrate assimilation Source: UniProtKB-KW
  2. protein localization Source: CGD
  3. regulation of RNA biosynthetic process Source: GOC
  4. regulation of nitrogen utilization Source: CGD
Complete GO annotation...

Keywords - Biological processi

Nitrate assimilation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein URE2
Gene namesi
Name:URE2
ORF Names:CaO19.155, CaO19.7794
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0003152. URE2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Protein URE2
PRO_0000186004Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi5476.CAL0003152.

Structurei

3D structure databases

ProteinModelPortaliQ96WL3.
SMRiQ96WL3. Positions 88-344.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini102 – 18685GST N-terminal
Add
BLAST
Domaini195 – 344150GST C-terminal
Add
BLAST

Sequence similaritiesi

Belongs to the GST superfamily.

Phylogenomic databases

eggNOGiCOG0625.
KOiK00799.
OrthoDBiEOG7KWSWX.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR017298. Prion_URE2.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PIRSFiPIRSF037861. Prion_URE2. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96WL3-1 [UniParc]FASTAAdd to Basket

« Hide

MMSTDQHIQQ NMNDNSNNSN NSNNNNTNNN NNNQSVNVNV NNTNNNTQTI    50
SNLSAGLKSV SLTDQQQNEV NLNLLQQQLH QEASTQQQQS RITQFFQNQP 100
TEGFTLFSHR SAPNGFKVAI ILSELNLPFN TFFLDFNNGE QRTPEFVTIN 150
PNARVPALID HYNDNTSIWE SGAITLYLVS KYLKENGECS LWSNNLIEQS 200
QISSWLFFQT SGHAPMIGQA LHFRYFHSCP VPSAVERYTD EVRRVYGVIE 250
MALAERREAL IMDLDVENAA AYSAGTTPLS QSRFFDHPVW LVGDRTTVAD 300
LSFVPWNNVV DRIGINLKVE FPEVYKWTKH MMQRPAVKRA LRGD 344
Length:344
Mass (Da):39,136
Last modified:December 1, 2001 - v1
Checksum:i09D18470BF36C0CD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF260777 Genomic DNA. Translation: AAK51643.2.
AF525173 Genomic DNA. Translation: AAM91946.1.
AACQ01000255 Genomic DNA. Translation: EAK91340.1.
AACQ01000254 Genomic DNA. Translation: EAK91354.1.
RefSeqiXP_710592.1. XM_705500.1.
XP_710606.1. XM_705514.1.

Genome annotation databases

GeneIDi3647795.
3647808.
KEGGical:CaO19.155.
cal:CaO19.7794.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF260777 Genomic DNA. Translation: AAK51643.2 .
AF525173 Genomic DNA. Translation: AAM91946.1 .
AACQ01000255 Genomic DNA. Translation: EAK91340.1 .
AACQ01000254 Genomic DNA. Translation: EAK91354.1 .
RefSeqi XP_710592.1. XM_705500.1.
XP_710606.1. XM_705514.1.

3D structure databases

ProteinModelPortali Q96WL3.
SMRi Q96WL3. Positions 88-344.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0003152.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3647795.
3647808.
KEGGi cal:CaO19.155.
cal:CaO19.7794.

Organism-specific databases

CGDi CAL0003152. URE2.

Phylogenomic databases

eggNOGi COG0625.
KOi K00799.
OrthoDBi EOG7KWSWX.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR017298. Prion_URE2.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF037861. Prion_URE2. 1 hit.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prion characteristics of the URE2 protein of various yeast species."
    Fernandez-Bellot E., Baudin-Baillieu A., Cullin C.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Conservation of a portion of the S. cerevisiae Ure2p prion domain that interacts with the full-length protein."
    Edskes H.K., Wickner R.B.
    Proc. Natl. Acad. Sci. U.S.A. 99:16384-16391(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Darlington.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiURE2_CANAL
AccessioniPrimary (citable) accession number: Q96WL3
Secondary accession number(s): Q59LH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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