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Protein

Protein URE2

Gene

URE2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity).By similarity

GO - Molecular functioni

  • transcription corepressor activity Source: CGD

GO - Biological processi

  • nitrate assimilation Source: UniProtKB-KW
  • protein localization Source: CGD
  • regulation of nitrogen utilization Source: CGD

Keywordsi

Biological processNitrate assimilation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein URE2
Gene namesi
Name:URE2
Ordered Locus Names:CAALFM_C204710CA
ORF Names:CaO19.155, CaO19.7794
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 2

Organism-specific databases

CGDiCAL0000198677 URE2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001860041 – 344Protein URE2Add BLAST344

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ96WL3
SMRiQ96WL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 186GST N-terminalAdd BLAST85
Domaini195 – 344GST C-terminalAdd BLAST150

Sequence similaritiesi

Belongs to the GST superfamily.Curated

Phylogenomic databases

InParanoidiQ96WL3
KOiK00799
OrthoDBiEOG092C499E

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
IPR017298 Ure2
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
PIRSFiPIRSF037861 Prion_URE2, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q96WL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSTDQHIQQ NMNDNSNNSN NSNNNNTNNN NNNQSVNVNV NNTNNNTQTI
60 70 80 90 100
SNLSAGLKSV SLTDQQQNEV NLNLLQQQLH QEASTQQQQS RITQFFQNQP
110 120 130 140 150
TEGFTLFSHR SAPNGFKVAI ILSELNLPFN TFFLDFNNGE QRTPEFVTIN
160 170 180 190 200
PNARVPALID HYNDNTSIWE SGAITLYLVS KYLKENGECS LWSNNLIEQS
210 220 230 240 250
QISSWLFFQT SGHAPMIGQA LHFRYFHSCP VPSAVERYTD EVRRVYGVIE
260 270 280 290 300
MALAERREAL IMDLDVENAA AYSAGTTPLS QSRFFDHPVW LVGDRTTVAD
310 320 330 340
LSFVPWNNVV DRIGINLKVE FPEVYKWTKH MMQRPAVKRA LRGD
Length:344
Mass (Da):39,136
Last modified:December 1, 2001 - v1
Checksum:i09D18470BF36C0CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260777 Genomic DNA Translation: AAK51643.2
AF525173 Genomic DNA Translation: AAM91946.1
CP017624 Genomic DNA Translation: AOW27495.1
RefSeqiXP_710606.1, XM_705514.2

Genome annotation databases

EnsemblFungiiAOW27495; AOW27495; CAALFM_C204710CA
GeneIDi3647795
KEGGical:CAALFM_C204710CA

Similar proteinsi

Entry informationi

Entry nameiURE2_CANAL
AccessioniPrimary (citable) accession number: Q96WL3
Secondary accession number(s): A0A1D8PHB4, Q59LH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health