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Protein

Protein URE2

Gene

URE2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity).By similarity

GO - Molecular functioni

  • transcription corepressor activity Source: CGD

GO - Biological processi

  • negative regulation of nucleic acid-templated transcription Source: GOC
  • nitrate assimilation Source: UniProtKB-KW
  • protein localization Source: CGD
  • regulation of nitrogen utilization Source: CGD
Complete GO annotation...

Keywords - Biological processi

Nitrate assimilation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein URE2
Gene namesi
Name:URE2
ORF Names:CaO19.155, CaO19.7794
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0003152. URE2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Protein URE2PRO_0000186004Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi5476.CAL0003152.

Structurei

3D structure databases

ProteinModelPortaliQ96WL3.
SMRiQ96WL3. Positions 88-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini102 – 18685GST N-terminalAdd
BLAST
Domaini195 – 344150GST C-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the GST superfamily.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0625.
InParanoidiQ96WL3.
KOiK00799.
OrthoDBiEOG7KWSWX.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
IPR017298. Ure2.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PIRSFiPIRSF037861. Prion_URE2. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96WL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSTDQHIQQ NMNDNSNNSN NSNNNNTNNN NNNQSVNVNV NNTNNNTQTI
60 70 80 90 100
SNLSAGLKSV SLTDQQQNEV NLNLLQQQLH QEASTQQQQS RITQFFQNQP
110 120 130 140 150
TEGFTLFSHR SAPNGFKVAI ILSELNLPFN TFFLDFNNGE QRTPEFVTIN
160 170 180 190 200
PNARVPALID HYNDNTSIWE SGAITLYLVS KYLKENGECS LWSNNLIEQS
210 220 230 240 250
QISSWLFFQT SGHAPMIGQA LHFRYFHSCP VPSAVERYTD EVRRVYGVIE
260 270 280 290 300
MALAERREAL IMDLDVENAA AYSAGTTPLS QSRFFDHPVW LVGDRTTVAD
310 320 330 340
LSFVPWNNVV DRIGINLKVE FPEVYKWTKH MMQRPAVKRA LRGD
Length:344
Mass (Da):39,136
Last modified:December 1, 2001 - v1
Checksum:i09D18470BF36C0CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260777 Genomic DNA. Translation: AAK51643.2.
AF525173 Genomic DNA. Translation: AAM91946.1.
AACQ01000255 Genomic DNA. Translation: EAK91340.1.
AACQ01000254 Genomic DNA. Translation: EAK91354.1.
RefSeqiXP_710592.1. XM_705500.1.
XP_710606.1. XM_705514.1.

Genome annotation databases

GeneIDi3647795.
3647808.
KEGGical:CaO19.155.
cal:CaO19.7794.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260777 Genomic DNA. Translation: AAK51643.2.
AF525173 Genomic DNA. Translation: AAM91946.1.
AACQ01000255 Genomic DNA. Translation: EAK91340.1.
AACQ01000254 Genomic DNA. Translation: EAK91354.1.
RefSeqiXP_710592.1. XM_705500.1.
XP_710606.1. XM_705514.1.

3D structure databases

ProteinModelPortaliQ96WL3.
SMRiQ96WL3. Positions 88-344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0003152.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3647795.
3647808.
KEGGical:CaO19.155.
cal:CaO19.7794.

Organism-specific databases

CGDiCAL0003152. URE2.

Phylogenomic databases

eggNOGiCOG0625.
InParanoidiQ96WL3.
KOiK00799.
OrthoDBiEOG7KWSWX.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
IPR017298. Ure2.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PIRSFiPIRSF037861. Prion_URE2. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prion characteristics of the URE2 protein of various yeast species."
    Fernandez-Bellot E., Baudin-Baillieu A., Cullin C.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Conservation of a portion of the S. cerevisiae Ure2p prion domain that interacts with the full-length protein."
    Edskes H.K., Wickner R.B.
    Proc. Natl. Acad. Sci. U.S.A. 99:16384-16391(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Darlington.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiURE2_CANAL
AccessioniPrimary (citable) accession number: Q96WL3
Secondary accession number(s): Q59LH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: December 1, 2001
Last modified: April 1, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.