Q96WL3 (URE2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein URE2

Gene names

Name:	URE2
ORF Names:	CaO19.155, CaO19.7794

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the GST superfamily. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Biological process	Nitrate assimilation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nitrate assimilation Inferred from electronic annotation. Source: UniProtKB-KW protein localization Inferred from genetic interaction Ref.2. Source: CGD regulation of nitrogen utilization Inferred from genetic interaction Ref.2. Source: CGD
Molecular_function	transcription corepressor activity Inferred from genetic interaction Ref.2. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Protein URE2		PRO_0000186004
Regions
	Domain	102 – 186	85	GST N-terminal
	Domain	195 – 344	150	GST C-terminal

Sequences

	Sequence		Length	Mass (Da)
	Q96WL3 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 09D18470BF36C0CD	FASTA	344	39,136
	10 20 30 40 50 60 MMSTDQHIQQ NMNDNSNNSN NSNNNNTNNN NNNQSVNVNV NNTNNNTQTI SNLSAGLKSV 70 80 90 100 110 120 SLTDQQQNEV NLNLLQQQLH QEASTQQQQS RITQFFQNQP TEGFTLFSHR SAPNGFKVAI 130 140 150 160 170 180 ILSELNLPFN TFFLDFNNGE QRTPEFVTIN PNARVPALID HYNDNTSIWE SGAITLYLVS 190 200 210 220 230 240 KYLKENGECS LWSNNLIEQS QISSWLFFQT SGHAPMIGQA LHFRYFHSCP VPSAVERYTD 250 260 270 280 290 300 EVRRVYGVIE MALAERREAL IMDLDVENAA AYSAGTTPLS QSRFFDHPVW LVGDRTTVAD 310 320 330 340 LSFVPWNNVV DRIGINLKVE FPEVYKWTKH MMQRPAVKRA LRGD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prion characteristics of the URE2 protein of various yeast species." Fernandez-Bellot E., Baudin-Baillieu A., Cullin C. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Conservation of a portion of the S. cerevisiae Ure2p prion domain that interacts with the full-length protein." Edskes H.K., Wickner R.B. Proc. Natl. Acad. Sci. U.S.A. 99:16384-16391(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Darlington.
[3]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF260777 Genomic DNA. Translation: AAK51643.2. AF525173 Genomic DNA. Translation: AAM91946.1. AACQ01000255 Genomic DNA. Translation: EAK91340.1. AACQ01000254 Genomic DNA. Translation: EAK91354.1.
RefSeq	XP_710592.1. XM_705500.1. XP_710606.1. XM_705514.1.
3D structure databases
ProteinModelPortal	Q96WL3.
SMR	Q96WL3. Positions 88-344.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0003152.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3647795. 3647808.
KEGG	cal:CaO19.155. cal:CaO19.7794.
Organism-specific databases
CGD	CAL0003152. URE2.
Phylogenomic databases
eggNOG	COG0625.
KO	K00799.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR017298. Prion_URE2. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PIRSF	PIRSF037861. Prion_URE2. 1 hit.
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

URE2_CANAL

Accession

Primary (citable) accession number: Q96WL3
Secondary accession number(s): Q59LH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program