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Q96WL3

- URE2_CANAL

UniProt

Q96WL3 - URE2_CANAL

Protein

Protein URE2

Gene

URE2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine By similarity.By similarity

    GO - Molecular functioni

    1. transcription corepressor activity Source: CGD

    GO - Biological processi

    1. nitrate assimilation Source: UniProtKB-KW
    2. protein localization Source: CGD
    3. regulation of nitrogen utilization Source: CGD
    4. regulation of RNA biosynthetic process Source: GOC

    Keywords - Biological processi

    Nitrate assimilation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein URE2
    Gene namesi
    Name:URE2
    ORF Names:CaO19.155, CaO19.7794
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0003152. URE2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344Protein URE2PRO_0000186004Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi5476.CAL0003152.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96WL3.
    SMRiQ96WL3. Positions 88-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini102 – 18685GST N-terminalAdd
    BLAST
    Domaini195 – 344150GST C-terminalAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GST superfamily.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0625.
    KOiK00799.
    OrthoDBiEOG7KWSWX.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR017298. Prion_URE2.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037861. Prion_URE2. 1 hit.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96WL3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMSTDQHIQQ NMNDNSNNSN NSNNNNTNNN NNNQSVNVNV NNTNNNTQTI    50
    SNLSAGLKSV SLTDQQQNEV NLNLLQQQLH QEASTQQQQS RITQFFQNQP 100
    TEGFTLFSHR SAPNGFKVAI ILSELNLPFN TFFLDFNNGE QRTPEFVTIN 150
    PNARVPALID HYNDNTSIWE SGAITLYLVS KYLKENGECS LWSNNLIEQS 200
    QISSWLFFQT SGHAPMIGQA LHFRYFHSCP VPSAVERYTD EVRRVYGVIE 250
    MALAERREAL IMDLDVENAA AYSAGTTPLS QSRFFDHPVW LVGDRTTVAD 300
    LSFVPWNNVV DRIGINLKVE FPEVYKWTKH MMQRPAVKRA LRGD 344
    Length:344
    Mass (Da):39,136
    Last modified:December 1, 2001 - v1
    Checksum:i09D18470BF36C0CD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF260777 Genomic DNA. Translation: AAK51643.2.
    AF525173 Genomic DNA. Translation: AAM91946.1.
    AACQ01000255 Genomic DNA. Translation: EAK91340.1.
    AACQ01000254 Genomic DNA. Translation: EAK91354.1.
    RefSeqiXP_710592.1. XM_705500.1.
    XP_710606.1. XM_705514.1.

    Genome annotation databases

    GeneIDi3647795.
    3647808.
    KEGGical:CaO19.155.
    cal:CaO19.7794.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF260777 Genomic DNA. Translation: AAK51643.2 .
    AF525173 Genomic DNA. Translation: AAM91946.1 .
    AACQ01000255 Genomic DNA. Translation: EAK91340.1 .
    AACQ01000254 Genomic DNA. Translation: EAK91354.1 .
    RefSeqi XP_710592.1. XM_705500.1.
    XP_710606.1. XM_705514.1.

    3D structure databases

    ProteinModelPortali Q96WL3.
    SMRi Q96WL3. Positions 88-344.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0003152.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3647795.
    3647808.
    KEGGi cal:CaO19.155.
    cal:CaO19.7794.

    Organism-specific databases

    CGDi CAL0003152. URE2.

    Phylogenomic databases

    eggNOGi COG0625.
    KOi K00799.
    OrthoDBi EOG7KWSWX.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR017298. Prion_URE2.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037861. Prion_URE2. 1 hit.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prion characteristics of the URE2 protein of various yeast species."
      Fernandez-Bellot E., Baudin-Baillieu A., Cullin C.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Conservation of a portion of the S. cerevisiae Ure2p prion domain that interacts with the full-length protein."
      Edskes H.K., Wickner R.B.
      Proc. Natl. Acad. Sci. U.S.A. 99:16384-16391(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Darlington.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiURE2_CANAL
    AccessioniPrimary (citable) accession number: Q96WL3
    Secondary accession number(s): Q59LH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3